Role of mitochondrial alterations in human cancer progression and cancer immunity
Abstract Dysregulating cellular metabolism is one of the emerging cancer hallmarks. Mitochondria are essential organelles responsible for numerous physiologic processes, such as energy production, cellular metabolism, apoptosis, and calcium and redox homeostasis. Although the “Warburg effect,” in wh...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-07-01
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| Series: | Journal of Biomedical Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12929-023-00956-w |
| _version_ | 1797752637757587456 |
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| author | Sheng-Fan Wang Ling-Ming Tseng Hsin-Chen Lee |
| author_facet | Sheng-Fan Wang Ling-Ming Tseng Hsin-Chen Lee |
| author_sort | Sheng-Fan Wang |
| collection | DOAJ |
| description | Abstract Dysregulating cellular metabolism is one of the emerging cancer hallmarks. Mitochondria are essential organelles responsible for numerous physiologic processes, such as energy production, cellular metabolism, apoptosis, and calcium and redox homeostasis. Although the “Warburg effect,” in which cancer cells prefer aerobic glycolysis even under normal oxygen circumstances, was proposed a century ago, how mitochondrial dysfunction contributes to cancer progression is still unclear. This review discusses recent progress in the alterations of mitochondrial DNA (mtDNA) and mitochondrial dynamics in cancer malignant progression. Moreover, we integrate the possible regulatory mechanism of mitochondrial dysfunction–mediated mitochondrial retrograde signaling pathways, including mitochondrion-derived molecules (reactive oxygen species, calcium, oncometabolites, and mtDNA) and mitochondrial stress response pathways (mitochondrial unfolded protein response and integrated stress response) in cancer progression and provide the possible therapeutic targets. Furthermore, we discuss recent findings on the role of mitochondria in the immune regulatory function of immune cells and reveal the impact of the tumor microenvironment and metabolism remodeling on cancer immunity. Targeting the mitochondria and metabolism might improve cancer immunotherapy. These findings suggest that targeting mitochondrial retrograde signaling in cancer malignancy and modulating metabolism and mitochondria in cancer immunity might be promising treatment strategies for cancer patients and provide precise and personalized medicine against cancer. |
| first_indexed | 2024-03-12T17:07:23Z |
| format | Article |
| id | doaj.art-ad0a490697bf4baa89f6d1f5dbaab689 |
| institution | Directory Open Access Journal |
| issn | 1423-0127 |
| language | English |
| last_indexed | 2024-03-12T17:07:23Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Biomedical Science |
| spelling | doaj.art-ad0a490697bf4baa89f6d1f5dbaab6892023-08-06T11:21:36ZengBMCJournal of Biomedical Science1423-01272023-07-0130111910.1186/s12929-023-00956-wRole of mitochondrial alterations in human cancer progression and cancer immunitySheng-Fan Wang0Ling-Ming Tseng1Hsin-Chen Lee2Department of Pharmacy, Taipei Veterans General HospitalDivision of General Surgery, Department of Surgery, Comprehensive Breast Health Center, Taipei Veterans General HospitalDepartment and Institute of Pharmacology, College of Medicine, National Yang Ming Chiao Tung UniversityAbstract Dysregulating cellular metabolism is one of the emerging cancer hallmarks. Mitochondria are essential organelles responsible for numerous physiologic processes, such as energy production, cellular metabolism, apoptosis, and calcium and redox homeostasis. Although the “Warburg effect,” in which cancer cells prefer aerobic glycolysis even under normal oxygen circumstances, was proposed a century ago, how mitochondrial dysfunction contributes to cancer progression is still unclear. This review discusses recent progress in the alterations of mitochondrial DNA (mtDNA) and mitochondrial dynamics in cancer malignant progression. Moreover, we integrate the possible regulatory mechanism of mitochondrial dysfunction–mediated mitochondrial retrograde signaling pathways, including mitochondrion-derived molecules (reactive oxygen species, calcium, oncometabolites, and mtDNA) and mitochondrial stress response pathways (mitochondrial unfolded protein response and integrated stress response) in cancer progression and provide the possible therapeutic targets. Furthermore, we discuss recent findings on the role of mitochondria in the immune regulatory function of immune cells and reveal the impact of the tumor microenvironment and metabolism remodeling on cancer immunity. Targeting the mitochondria and metabolism might improve cancer immunotherapy. These findings suggest that targeting mitochondrial retrograde signaling in cancer malignancy and modulating metabolism and mitochondria in cancer immunity might be promising treatment strategies for cancer patients and provide precise and personalized medicine against cancer.https://doi.org/10.1186/s12929-023-00956-wMitochondriaCancer progressionRetrograde signalingCancer immunity |
| spellingShingle | Sheng-Fan Wang Ling-Ming Tseng Hsin-Chen Lee Role of mitochondrial alterations in human cancer progression and cancer immunity Journal of Biomedical Science Mitochondria Cancer progression Retrograde signaling Cancer immunity |
| title | Role of mitochondrial alterations in human cancer progression and cancer immunity |
| title_full | Role of mitochondrial alterations in human cancer progression and cancer immunity |
| title_fullStr | Role of mitochondrial alterations in human cancer progression and cancer immunity |
| title_full_unstemmed | Role of mitochondrial alterations in human cancer progression and cancer immunity |
| title_short | Role of mitochondrial alterations in human cancer progression and cancer immunity |
| title_sort | role of mitochondrial alterations in human cancer progression and cancer immunity |
| topic | Mitochondria Cancer progression Retrograde signaling Cancer immunity |
| url | https://doi.org/10.1186/s12929-023-00956-w |
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