Immunobiology and Application of <i>Aloe vera</i>-Based Scaffolds in Tissue Engineering
Aloe vera (AV), a succulent plant belonging to the Liliaceae family, has been widely used for biomedical and pharmaceutical application. Its popularity stems from several of its bioactive components that have anti-oxidant, anti-microbial, anti-inflammatory and even immunomodulatory effects. Given su...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/4/1708 |
| _version_ | 1797412591054618624 |
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| author | Saeedeh Darzi Kallyanashis Paul Shanilka Leitan Jerome A. Werkmeister Shayanti Mukherjee |
| author_facet | Saeedeh Darzi Kallyanashis Paul Shanilka Leitan Jerome A. Werkmeister Shayanti Mukherjee |
| author_sort | Saeedeh Darzi |
| collection | DOAJ |
| description | Aloe vera (AV), a succulent plant belonging to the Liliaceae family, has been widely used for biomedical and pharmaceutical application. Its popularity stems from several of its bioactive components that have anti-oxidant, anti-microbial, anti-inflammatory and even immunomodulatory effects. Given such unique multi-modal biological impact, AV has been considered as a biomaterial for regenerative medicine and tissue engineering applications, where tissue repair and neo-angiogenesis are vital. This review outlines the growing scientific evidence that demonstrates the advantage of AV as tissue engineering scaffolds. We particularly highlight the recent advances in the application of AV-based scaffolds. From a tissue engineering perspective, it is pivotal that the implanted scaffolds strike an appropriate foreign body response to be well-accepted in the body without complications. Herein, we highlight the key cellular processes that regulate the foreign body response to implanted scaffolds and underline the immunomodulatory effects incurred by AV on the innate and adaptive system. Given that AV has several beneficial components, we discuss the importance of delving deeper into uncovering its action mechanism and thereby improving material design strategies for better tissue engineering constructs for biomedical applications. |
| first_indexed | 2024-03-09T05:05:21Z |
| format | Article |
| id | doaj.art-ad0eb93c80144022abc6c5ed2bfdf108 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T05:05:21Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ad0eb93c80144022abc6c5ed2bfdf1082023-12-03T12:55:48ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-02-01224170810.3390/ijms22041708Immunobiology and Application of <i>Aloe vera</i>-Based Scaffolds in Tissue EngineeringSaeedeh Darzi0Kallyanashis Paul1Shanilka Leitan2Jerome A. Werkmeister3Shayanti Mukherjee4The Ritchie Centre, Hudson Institute of Medical Research, Clayton 3168, AustraliaThe Ritchie Centre, Hudson Institute of Medical Research, Clayton 3168, AustraliaThe Ritchie Centre, Hudson Institute of Medical Research, Clayton 3168, AustraliaThe Ritchie Centre, Hudson Institute of Medical Research, Clayton 3168, AustraliaThe Ritchie Centre, Hudson Institute of Medical Research, Clayton 3168, AustraliaAloe vera (AV), a succulent plant belonging to the Liliaceae family, has been widely used for biomedical and pharmaceutical application. Its popularity stems from several of its bioactive components that have anti-oxidant, anti-microbial, anti-inflammatory and even immunomodulatory effects. Given such unique multi-modal biological impact, AV has been considered as a biomaterial for regenerative medicine and tissue engineering applications, where tissue repair and neo-angiogenesis are vital. This review outlines the growing scientific evidence that demonstrates the advantage of AV as tissue engineering scaffolds. We particularly highlight the recent advances in the application of AV-based scaffolds. From a tissue engineering perspective, it is pivotal that the implanted scaffolds strike an appropriate foreign body response to be well-accepted in the body without complications. Herein, we highlight the key cellular processes that regulate the foreign body response to implanted scaffolds and underline the immunomodulatory effects incurred by AV on the innate and adaptive system. Given that AV has several beneficial components, we discuss the importance of delving deeper into uncovering its action mechanism and thereby improving material design strategies for better tissue engineering constructs for biomedical applications.https://www.mdpi.com/1422-0067/22/4/1708AVbiomaterialsregenerative medicineforeign body responsemacromoleculesanti-inflammatory material |
| spellingShingle | Saeedeh Darzi Kallyanashis Paul Shanilka Leitan Jerome A. Werkmeister Shayanti Mukherjee Immunobiology and Application of <i>Aloe vera</i>-Based Scaffolds in Tissue Engineering International Journal of Molecular Sciences AV biomaterials regenerative medicine foreign body response macromolecules anti-inflammatory material |
| title | Immunobiology and Application of <i>Aloe vera</i>-Based Scaffolds in Tissue Engineering |
| title_full | Immunobiology and Application of <i>Aloe vera</i>-Based Scaffolds in Tissue Engineering |
| title_fullStr | Immunobiology and Application of <i>Aloe vera</i>-Based Scaffolds in Tissue Engineering |
| title_full_unstemmed | Immunobiology and Application of <i>Aloe vera</i>-Based Scaffolds in Tissue Engineering |
| title_short | Immunobiology and Application of <i>Aloe vera</i>-Based Scaffolds in Tissue Engineering |
| title_sort | immunobiology and application of i aloe vera i based scaffolds in tissue engineering |
| topic | AV biomaterials regenerative medicine foreign body response macromolecules anti-inflammatory material |
| url | https://www.mdpi.com/1422-0067/22/4/1708 |
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