Malaria transmission and insecticide resistance of <it>Anopheles gambiae </it>in Libreville and Port-Gentil, Gabon
<p>Abstract</p> <p>Background</p> <p>Urban malaria is a major health priority for civilian and militaries populations. A preliminary entomologic study has been conducted in 2006-2007, in the French military camps of the two mains towns of Gabon: Libreville and Port-Gent...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2010-11-01
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| Series: | Malaria Journal |
| Online Access: | http://www.malariajournal.com/content/9/1/321 |
| _version_ | 1818262968294440960 |
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| author | Kombila Maryvonne Rogier Christophe Amalvict Rémi Pradines Bruno Jarjaval Fanny Coffinet Thierry Mourou Jean-Romain Pagès Frédéric |
| author_facet | Kombila Maryvonne Rogier Christophe Amalvict Rémi Pradines Bruno Jarjaval Fanny Coffinet Thierry Mourou Jean-Romain Pagès Frédéric |
| author_sort | Kombila Maryvonne |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Urban malaria is a major health priority for civilian and militaries populations. A preliminary entomologic study has been conducted in 2006-2007, in the French military camps of the two mains towns of Gabon: Libreville and Port-Gentil. The aim was to assess the malaria transmission risk for troops.</p> <p>Methods</p> <p>Mosquitoes sampled by human landing collection were identified morphologically and by molecular methods. The <it>Plasmodium falciparum </it>circumsporozoïte (CSP) indexes were measured by ELISA, and the entomological inoculation rates (EIR) were calculated for both areas. Molecular assessments of pyrethroid knock down <it>(kdr</it>) resistance and of insensitive acetylcholinesterase resistance were conducted.</p> <p>Results</p> <p>In Libreville, <it>Anopheles gambiae s.s</it>. S form was the only specie of the <it>An. gambiae </it>complex present and was responsible of 9.4 bites per person per night. The circumsporozoïte index was 0.15% and the entomological inoculation rate estimated to be 1.23 infective bites during the four months period. In Port-Gentil, <it>Anopheles melas </it>(75.5% of catches) and <it>An. gambiae s.s</it>. S form (24.5%) were responsible of 58.7 bites per person per night. The CSP indexes were of 1.67% for <it>An. gambiae s.s </it>and 0.28% for <it>An. melas </it>and the EIRs were respectively of 1.8 infective bites per week and of 0.8 infective bites per week. Both <it>kdr-w </it>and <it>kdr-e </it>mutations in <it>An. gambiae </it>S form were found in Libreville and in Port-Gentil. Insensitive acetylcholinesterase has been detected for the first time in Gabon in Libreville.</p> <p>Conclusion</p> <p>Malaria transmission exists in both town, but with high difference in the level of risk. The co-occurrence of molecular resistances to the main families of insecticide has implications for the effectiveness of the current vector control programmes that are based on pyrethroid-impregnated bed nets.</p> |
| first_indexed | 2024-12-12T19:11:33Z |
| format | Article |
| id | doaj.art-ad0eee914d8b4fc0bbe37d8b8451b22f |
| institution | Directory Open Access Journal |
| issn | 1475-2875 |
| language | English |
| last_indexed | 2024-12-12T19:11:33Z |
| publishDate | 2010-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Malaria Journal |
| spelling | doaj.art-ad0eee914d8b4fc0bbe37d8b8451b22f2022-12-22T00:14:50ZengBMCMalaria Journal1475-28752010-11-019132110.1186/1475-2875-9-321Malaria transmission and insecticide resistance of <it>Anopheles gambiae </it>in Libreville and Port-Gentil, GabonKombila MaryvonneRogier ChristopheAmalvict RémiPradines BrunoJarjaval FannyCoffinet ThierryMourou Jean-RomainPagès Frédéric<p>Abstract</p> <p>Background</p> <p>Urban malaria is a major health priority for civilian and militaries populations. A preliminary entomologic study has been conducted in 2006-2007, in the French military camps of the two mains towns of Gabon: Libreville and Port-Gentil. The aim was to assess the malaria transmission risk for troops.</p> <p>Methods</p> <p>Mosquitoes sampled by human landing collection were identified morphologically and by molecular methods. The <it>Plasmodium falciparum </it>circumsporozoïte (CSP) indexes were measured by ELISA, and the entomological inoculation rates (EIR) were calculated for both areas. Molecular assessments of pyrethroid knock down <it>(kdr</it>) resistance and of insensitive acetylcholinesterase resistance were conducted.</p> <p>Results</p> <p>In Libreville, <it>Anopheles gambiae s.s</it>. S form was the only specie of the <it>An. gambiae </it>complex present and was responsible of 9.4 bites per person per night. The circumsporozoïte index was 0.15% and the entomological inoculation rate estimated to be 1.23 infective bites during the four months period. In Port-Gentil, <it>Anopheles melas </it>(75.5% of catches) and <it>An. gambiae s.s</it>. S form (24.5%) were responsible of 58.7 bites per person per night. The CSP indexes were of 1.67% for <it>An. gambiae s.s </it>and 0.28% for <it>An. melas </it>and the EIRs were respectively of 1.8 infective bites per week and of 0.8 infective bites per week. Both <it>kdr-w </it>and <it>kdr-e </it>mutations in <it>An. gambiae </it>S form were found in Libreville and in Port-Gentil. Insensitive acetylcholinesterase has been detected for the first time in Gabon in Libreville.</p> <p>Conclusion</p> <p>Malaria transmission exists in both town, but with high difference in the level of risk. The co-occurrence of molecular resistances to the main families of insecticide has implications for the effectiveness of the current vector control programmes that are based on pyrethroid-impregnated bed nets.</p>http://www.malariajournal.com/content/9/1/321 |
| spellingShingle | Kombila Maryvonne Rogier Christophe Amalvict Rémi Pradines Bruno Jarjaval Fanny Coffinet Thierry Mourou Jean-Romain Pagès Frédéric Malaria transmission and insecticide resistance of <it>Anopheles gambiae </it>in Libreville and Port-Gentil, Gabon Malaria Journal |
| title | Malaria transmission and insecticide resistance of <it>Anopheles gambiae </it>in Libreville and Port-Gentil, Gabon |
| title_full | Malaria transmission and insecticide resistance of <it>Anopheles gambiae </it>in Libreville and Port-Gentil, Gabon |
| title_fullStr | Malaria transmission and insecticide resistance of <it>Anopheles gambiae </it>in Libreville and Port-Gentil, Gabon |
| title_full_unstemmed | Malaria transmission and insecticide resistance of <it>Anopheles gambiae </it>in Libreville and Port-Gentil, Gabon |
| title_short | Malaria transmission and insecticide resistance of <it>Anopheles gambiae </it>in Libreville and Port-Gentil, Gabon |
| title_sort | malaria transmission and insecticide resistance of it anopheles gambiae it in libreville and port gentil gabon |
| url | http://www.malariajournal.com/content/9/1/321 |
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