High-Mobility Group Nucleosome-Binding Protein 1 as Endogenous Ligand Induces Innate Immune Tolerance in a TLR4-Sirtuin-1 Dependent Manner in Human Blood Peripheral Mononuclear Cells

High-Mobility Group Nucleosome-Binding Protein 1 as Endogenous Ligand Induces Innate Immune Tolerance in a TLR4-Sirtuin-1 Dependent Manner in Human Blood Peripheral Mononuclear Cells

High-mobility group nucleosome-binding protein 1 (HMGN1) functions as a non-histone chromatin-binding protein in the cell nucleus. However, extracellular HMGN1 acts as an endogenous danger-associated inflammatory mediator (also called alarmin). We demonstrated that HMGN1 not only directly stimulated...

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Bibliographic Details
Main Authors: Rob J. W. Arts, Po-Kai Huang, De Yang, Leo A. B. Joosten, Jos W. M. van der Meer, Joost J. Oppenheim, Mihai G. Netea, Shih-Chin Cheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Immunology
Subjects:
high-mobility group nucleosome-binding protein 1
endotoxin tolerance
sterile inflammation
sirtuin-1
macrophages
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00526/full

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