Algorithmically Reconstructed Molecular Pathways as the New Generation of Prognostic Molecular Biomarkers in Human Solid Cancers

Algorithmically Reconstructed Molecular Pathways as the New Generation of Prognostic Molecular Biomarkers in Human Solid Cancers

Individual gene expression and molecular pathway activation profiles were shown to be effective biomarkers in many cancers. Here, we used the human interactome model to algorithmically build 7470 molecular pathways centered around individual gene products. We assessed their associations with tumor t...

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Bibliographic Details
Main Authors: Marianna Zolotovskaia, Maks Kovalenko, Polina Pugacheva, Victor Tkachev, Alexander Simonov, Maxim Sorokin, Alexander Seryakov, Andrew Garazha, Nurshat Gaifullin, Marina Sekacheva, Galina Zakharova, Anton A. Buzdin
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Proteomes
Subjects:
cancer
gene expression
molecular pathway
human interactome
prognostic biomarker
survival biomarker
Online Access:https://www.mdpi.com/2227-7382/11/3/26

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