Functional characteristics of tissue equivalents of various tissues using porous-permeable incubators of titanium nickelide
Pancreas cages form a functional fabric and allocate hormonal substances necessary for indemnification of the lost structures of a pancreas of an organism. And, at input in an organism of ß-cells deprived of a substrate, life cycle transplanted xenogeneic cages considerably decreases under the influ...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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Scientific Сentre for Family Health and Human Reproduction Problems
2015-04-01
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| Series: | Acta Biomedica Scientifica |
| Subjects: | |
| Online Access: | https://www.actabiomedica.ru/jour/article/view/36 |
| _version_ | 1826853482694443008 |
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| author | O. V. Kokorev V. N. Khodorenko G. T. Dambaev V. E. Gunther |
| author_facet | O. V. Kokorev V. N. Khodorenko G. T. Dambaev V. E. Gunther |
| author_sort | O. V. Kokorev |
| collection | DOAJ |
| description | Pancreas cages form a functional fabric and allocate hormonal substances necessary for indemnification of the lost structures of a pancreas of an organism. And, at input in an organism of ß-cells deprived of a substrate, life cycle transplanted xenogeneic cages considerably decreases under the influence of immune factors, during too time of a cage in an incubator function longer time, promoting construction of spatial architecture of new gland. The given methodology is effective in diabetes treatment as the transplanted cages it is very thin react to allocation of insulin depending on a condition homeostatic organism systems that is an actual problem at introduction of injections of insulin. Results of researches show that incubators of titanium nickelide are highly effective for their use as biocompatible matrixes. Features incubator spaces, and also a material titanium nickelide the titan promote creation fabric biosystems from various cages of an organism and to considerable prolongation of functional activity transplantation cages that accordingly conducts to increase in period of validity of therapeutic effect. Investigation have shown the formation of specific tissues in porous-permeable incubators of titanium nickelide for different cell populations. Allogeneic bone marrow cells immobilized in incubators of titanium nickelide possess antitumor (25%) and significant antimetastatic (45%) effect. The study of morphological parameters immunocompetent organs showed that administration of allogeneic bone marrow cells can decrease thymic regression, reduces splenomegaly in animals with transplantable tumors. Hepatocytes were implanted in porous materials of titanium nickelide mice with CCl4-induced hepatitis provided significant antitoxic effect. Obtained initial results promising pancreatic tissue-engineering in complex treatment of diabetes. It is noted that the use of incubators permeable porous nickel-titanium increase therapeutic effect and significantly prolongs effect of transplanted cells, as opposed their injecting. |
| first_indexed | 2024-03-08T12:19:10Z |
| format | Article |
| id | doaj.art-ad1192fac1fa4ad6ac4f35f66e08e69f |
| institution | Directory Open Access Journal |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| last_indexed | 2025-02-16T17:26:40Z |
| publishDate | 2015-04-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj.art-ad1192fac1fa4ad6ac4f35f66e08e69f2025-01-27T16:48:47ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962015-04-0102737936Functional characteristics of tissue equivalents of various tissues using porous-permeable incubators of titanium nickelideO. V. Kokorev0V. N. Khodorenko1G. T. Dambaev2V. E. Gunther3Research Institute of Medical Shape Memory Materials and ImplantsResearch Institute of Medical Shape Memory Materials and ImplantsSiberian State Medical UniversityResearch Institute of Medical Shape Memory Materials and ImplantsPancreas cages form a functional fabric and allocate hormonal substances necessary for indemnification of the lost structures of a pancreas of an organism. And, at input in an organism of ß-cells deprived of a substrate, life cycle transplanted xenogeneic cages considerably decreases under the influence of immune factors, during too time of a cage in an incubator function longer time, promoting construction of spatial architecture of new gland. The given methodology is effective in diabetes treatment as the transplanted cages it is very thin react to allocation of insulin depending on a condition homeostatic organism systems that is an actual problem at introduction of injections of insulin. Results of researches show that incubators of titanium nickelide are highly effective for their use as biocompatible matrixes. Features incubator spaces, and also a material titanium nickelide the titan promote creation fabric biosystems from various cages of an organism and to considerable prolongation of functional activity transplantation cages that accordingly conducts to increase in period of validity of therapeutic effect. Investigation have shown the formation of specific tissues in porous-permeable incubators of titanium nickelide for different cell populations. Allogeneic bone marrow cells immobilized in incubators of titanium nickelide possess antitumor (25%) and significant antimetastatic (45%) effect. The study of morphological parameters immunocompetent organs showed that administration of allogeneic bone marrow cells can decrease thymic regression, reduces splenomegaly in animals with transplantable tumors. Hepatocytes were implanted in porous materials of titanium nickelide mice with CCl4-induced hepatitis provided significant antitoxic effect. Obtained initial results promising pancreatic tissue-engineering in complex treatment of diabetes. It is noted that the use of incubators permeable porous nickel-titanium increase therapeutic effect and significantly prolongs effect of transplanted cells, as opposed their injecting.https://www.actabiomedica.ru/jour/article/view/36titanium nickelidetissueporous-permeable incubators |
| spellingShingle | O. V. Kokorev V. N. Khodorenko G. T. Dambaev V. E. Gunther Functional characteristics of tissue equivalents of various tissues using porous-permeable incubators of titanium nickelide Acta Biomedica Scientifica titanium nickelide tissue porous-permeable incubators |
| title | Functional characteristics of tissue equivalents of various tissues using porous-permeable incubators of titanium nickelide |
| title_full | Functional characteristics of tissue equivalents of various tissues using porous-permeable incubators of titanium nickelide |
| title_fullStr | Functional characteristics of tissue equivalents of various tissues using porous-permeable incubators of titanium nickelide |
| title_full_unstemmed | Functional characteristics of tissue equivalents of various tissues using porous-permeable incubators of titanium nickelide |
| title_short | Functional characteristics of tissue equivalents of various tissues using porous-permeable incubators of titanium nickelide |
| title_sort | functional characteristics of tissue equivalents of various tissues using porous permeable incubators of titanium nickelide |
| topic | titanium nickelide tissue porous-permeable incubators |
| url | https://www.actabiomedica.ru/jour/article/view/36 |
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