Convergence of Biofabrication Technologies and Cell Therapies for Wound Healing
Background: Cell therapy holds great promise for cutaneous wound treatment but presents practical and clinical challenges, mainly related to the lack of a supportive and inductive microenvironment for cells after transplantation. Main: This review delineates the challenges and opportunities in cell...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/12/2749 |
| _version_ | 1827637272498929664 |
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| author | Motaharesadat Hosseini Andrew J. Dalley Abbas Shafiee |
| author_facet | Motaharesadat Hosseini Andrew J. Dalley Abbas Shafiee |
| author_sort | Motaharesadat Hosseini |
| collection | DOAJ |
| description | Background: Cell therapy holds great promise for cutaneous wound treatment but presents practical and clinical challenges, mainly related to the lack of a supportive and inductive microenvironment for cells after transplantation. Main: This review delineates the challenges and opportunities in cell therapies for acute and chronic wounds and highlights the contribution of biofabricated matrices to skin reconstruction. The complexity of the wound healing process necessitates the development of matrices with properties comparable to the extracellular matrix in the skin for their structure and composition. Over recent years, emerging biofabrication technologies have shown a capacity for creating complex matrices. In cell therapy, multifunctional material-based matrices have benefits in enhancing cell retention and survival, reducing healing time, and preventing infection and cell transplant rejection. Additionally, they can improve the efficacy of cell therapy, owing to their potential to modulate cell behaviors and regulate spatiotemporal patterns of wound healing. Conclusion: The ongoing development of biofabrication technologies promises to deliver material-based matrices that are rich in supportive, phenotype patterning cell niches and are robust enough to provide physical protection for the cells during implantation. |
| first_indexed | 2024-03-09T15:58:37Z |
| format | Article |
| id | doaj.art-ad119fac5ec6452eb1703471b416011b |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T15:58:37Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-ad119fac5ec6452eb1703471b416011b2023-11-24T17:21:21ZengMDPI AGPharmaceutics1999-49232022-12-011412274910.3390/pharmaceutics14122749Convergence of Biofabrication Technologies and Cell Therapies for Wound HealingMotaharesadat Hosseini0Andrew J. Dalley1Abbas Shafiee2School of Mechanical, Medical and Process Engineering, Faculty of Engineering, Queensland University of Technology, Brisbane, QLD 4059, AustraliaHerston Biofabrication Institute, Metro North Hospital and Health Service, Brisbane, QLD 4029, AustraliaHerston Biofabrication Institute, Metro North Hospital and Health Service, Brisbane, QLD 4029, AustraliaBackground: Cell therapy holds great promise for cutaneous wound treatment but presents practical and clinical challenges, mainly related to the lack of a supportive and inductive microenvironment for cells after transplantation. Main: This review delineates the challenges and opportunities in cell therapies for acute and chronic wounds and highlights the contribution of biofabricated matrices to skin reconstruction. The complexity of the wound healing process necessitates the development of matrices with properties comparable to the extracellular matrix in the skin for their structure and composition. Over recent years, emerging biofabrication technologies have shown a capacity for creating complex matrices. In cell therapy, multifunctional material-based matrices have benefits in enhancing cell retention and survival, reducing healing time, and preventing infection and cell transplant rejection. Additionally, they can improve the efficacy of cell therapy, owing to their potential to modulate cell behaviors and regulate spatiotemporal patterns of wound healing. Conclusion: The ongoing development of biofabrication technologies promises to deliver material-based matrices that are rich in supportive, phenotype patterning cell niches and are robust enough to provide physical protection for the cells during implantation.https://www.mdpi.com/1999-4923/14/12/2749biomaterialcell therapymatrixregenerationskinstem cell |
| spellingShingle | Motaharesadat Hosseini Andrew J. Dalley Abbas Shafiee Convergence of Biofabrication Technologies and Cell Therapies for Wound Healing Pharmaceutics biomaterial cell therapy matrix regeneration skin stem cell |
| title | Convergence of Biofabrication Technologies and Cell Therapies for Wound Healing |
| title_full | Convergence of Biofabrication Technologies and Cell Therapies for Wound Healing |
| title_fullStr | Convergence of Biofabrication Technologies and Cell Therapies for Wound Healing |
| title_full_unstemmed | Convergence of Biofabrication Technologies and Cell Therapies for Wound Healing |
| title_short | Convergence of Biofabrication Technologies and Cell Therapies for Wound Healing |
| title_sort | convergence of biofabrication technologies and cell therapies for wound healing |
| topic | biomaterial cell therapy matrix regeneration skin stem cell |
| url | https://www.mdpi.com/1999-4923/14/12/2749 |
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