Cytoprotective Compounds Interfere with the Nutraceutical Potential of Bread Supplemented with Green Coffee Beans
The proliferation and motile activity of prostate epithelial (Pnt2) and cancer cells (DU-145; PC-3) in the presence of bioavailable compounds from green coffee beans (GCB), wholemeal wheat bread (WMWB), and its GCB-fortified variant were analyzed. The considerable cytostatic and anti-invasive activi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-07-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/8/7/228 |
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| author | Urszula Gawlik-Dziki Marcin Luty Dariusz Dziki Michał Świeca Katarzyna Piwowarczyk Urszula Złotek Jarosław Czyż |
| author_facet | Urszula Gawlik-Dziki Marcin Luty Dariusz Dziki Michał Świeca Katarzyna Piwowarczyk Urszula Złotek Jarosław Czyż |
| author_sort | Urszula Gawlik-Dziki |
| collection | DOAJ |
| description | The proliferation and motile activity of prostate epithelial (Pnt2) and cancer cells (DU-145; PC-3) in the presence of bioavailable compounds from green coffee beans (GCB), wholemeal wheat bread (WMWB), and its GCB-fortified variant were analyzed. The considerable cytostatic and anti-invasive activity of GCB extracts was correlated with its phenolic contents. WMWB extract contained significantly lower levels of phenolics but still displayed relatively high cytostatic activity. However, the cytostatic properties of WMWB compounds were hardly augmented by 3% GCB flour supplementation. The cytoprotective activity of the WMWB compounds exerts a negative impact on the cytostatic activity of GCB compounds. These data confirm the relatively high chemopreventive potential of GCB. However, they also indicate that subtle interactions between bioavailable compounds in GCB and WMWB can negatively affect the nutraceutic potential of the fortified bread. Apparently, gastrointestinal processing differentially regulates the availability of individual compounds and affects the balance between the cytostatic and cytoprotective activity of the whole product. Our data show that comprehensive research is necessary before the fortification of a specific carrier with a specific supplement can be recommended. |
| first_indexed | 2024-03-12T06:30:19Z |
| format | Article |
| id | doaj.art-ad13249bf7264a1da1d605c77012e38a |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-12T06:30:19Z |
| publishDate | 2019-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-ad13249bf7264a1da1d605c77012e38a2023-09-03T01:41:40ZengMDPI AGAntioxidants2076-39212019-07-018722810.3390/antiox8070228antiox8070228Cytoprotective Compounds Interfere with the Nutraceutical Potential of Bread Supplemented with Green Coffee BeansUrszula Gawlik-Dziki0Marcin Luty1Dariusz Dziki2Michał Świeca3Katarzyna Piwowarczyk4Urszula Złotek5Jarosław Czyż6Department of Biochemistry and Food Chemistry, University of Life Sciences, Skromna Str. 8, 20-704 Lublin, PolandDepartment of Cell Biology, Faculty of Biophysics, Biochemistry and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-378 Kraków, PolandDepartment of Thermal Technology and Food Process Engineering, University of Life Sciences, Doświadczalna Str. 44, 20-280 Lublin, PolandDepartment of Biochemistry and Food Chemistry, University of Life Sciences, Skromna Str. 8, 20-704 Lublin, PolandDepartment of Cell Biology, Faculty of Biophysics, Biochemistry and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-378 Kraków, PolandDepartment of Biochemistry and Food Chemistry, University of Life Sciences, Skromna Str. 8, 20-704 Lublin, PolandDepartment of Cell Biology, Faculty of Biophysics, Biochemistry and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-378 Kraków, PolandThe proliferation and motile activity of prostate epithelial (Pnt2) and cancer cells (DU-145; PC-3) in the presence of bioavailable compounds from green coffee beans (GCB), wholemeal wheat bread (WMWB), and its GCB-fortified variant were analyzed. The considerable cytostatic and anti-invasive activity of GCB extracts was correlated with its phenolic contents. WMWB extract contained significantly lower levels of phenolics but still displayed relatively high cytostatic activity. However, the cytostatic properties of WMWB compounds were hardly augmented by 3% GCB flour supplementation. The cytoprotective activity of the WMWB compounds exerts a negative impact on the cytostatic activity of GCB compounds. These data confirm the relatively high chemopreventive potential of GCB. However, they also indicate that subtle interactions between bioavailable compounds in GCB and WMWB can negatively affect the nutraceutic potential of the fortified bread. Apparently, gastrointestinal processing differentially regulates the availability of individual compounds and affects the balance between the cytostatic and cytoprotective activity of the whole product. Our data show that comprehensive research is necessary before the fortification of a specific carrier with a specific supplement can be recommended.https://www.mdpi.com/2076-3921/8/7/228coffee beanswholemeal breadprostate cancergastrointestinal digestioncytoprotection |
| spellingShingle | Urszula Gawlik-Dziki Marcin Luty Dariusz Dziki Michał Świeca Katarzyna Piwowarczyk Urszula Złotek Jarosław Czyż Cytoprotective Compounds Interfere with the Nutraceutical Potential of Bread Supplemented with Green Coffee Beans Antioxidants coffee beans wholemeal bread prostate cancer gastrointestinal digestion cytoprotection |
| title | Cytoprotective Compounds Interfere with the Nutraceutical Potential of Bread Supplemented with Green Coffee Beans |
| title_full | Cytoprotective Compounds Interfere with the Nutraceutical Potential of Bread Supplemented with Green Coffee Beans |
| title_fullStr | Cytoprotective Compounds Interfere with the Nutraceutical Potential of Bread Supplemented with Green Coffee Beans |
| title_full_unstemmed | Cytoprotective Compounds Interfere with the Nutraceutical Potential of Bread Supplemented with Green Coffee Beans |
| title_short | Cytoprotective Compounds Interfere with the Nutraceutical Potential of Bread Supplemented with Green Coffee Beans |
| title_sort | cytoprotective compounds interfere with the nutraceutical potential of bread supplemented with green coffee beans |
| topic | coffee beans wholemeal bread prostate cancer gastrointestinal digestion cytoprotection |
| url | https://www.mdpi.com/2076-3921/8/7/228 |
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