Structure and mechanism of mitochondrial electron transport chain
Respiration is one of the most vital and basic features of living organisms. In mammals, respiration is accomplished by respiratory chain complexes located on the mitochondrial inner membrane. In the past century, scientists put tremendous efforts in understanding these complexes, but failed to solv...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-02-01
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| Series: | Biomedical Journal |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2319417017303025 |
| _version_ | 1811186832916873216 |
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| author | Runyu Guo Jinke Gu Shuai Zong Meng Wu Maojun Yang |
| author_facet | Runyu Guo Jinke Gu Shuai Zong Meng Wu Maojun Yang |
| author_sort | Runyu Guo |
| collection | DOAJ |
| description | Respiration is one of the most vital and basic features of living organisms. In mammals, respiration is accomplished by respiratory chain complexes located on the mitochondrial inner membrane. In the past century, scientists put tremendous efforts in understanding these complexes, but failed to solve the high resolution structure until recently. In 2016, three research groups reported the structure of respiratory chain supercomplex from different species, and fortunately the structure solved by our group has the highest resolution. In this review, we will compare the recently solved structures of respirasome, probe into the relationship between cristae shape and respiratory chain organization, and discuss the highly disputed issues afterwards. Besides, our group reported the first high resolution structure of respirasome and medium resolution structure of megacomplex from cultured human cells this year. Definitely, these supercomplex structures will provide precious information for conquering the mitochondrial malfunction diseases. Keywords: Structure of respirasome, Cristae organization, Substrate channeling, Electron transfer pathway, Assembly of respirasome |
| first_indexed | 2024-04-11T13:51:44Z |
| format | Article |
| id | doaj.art-ad13c9f5c2a440f0a423772920c052f9 |
| institution | Directory Open Access Journal |
| issn | 2319-4170 |
| language | English |
| last_indexed | 2024-04-11T13:51:44Z |
| publishDate | 2018-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedical Journal |
| spelling | doaj.art-ad13c9f5c2a440f0a423772920c052f92022-12-22T04:20:33ZengElsevierBiomedical Journal2319-41702018-02-01411920Structure and mechanism of mitochondrial electron transport chainRunyu Guo0Jinke Gu1Shuai Zong2Meng Wu3Maojun Yang4Ministry of Education Key Laboratory of Protein Science, Tsinghua-Peking Joint Center for Life Sciences, Beijing, China; Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, ChinaMinistry of Education Key Laboratory of Protein Science, Tsinghua-Peking Joint Center for Life Sciences, Beijing, China; Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, ChinaMinistry of Education Key Laboratory of Protein Science, Tsinghua-Peking Joint Center for Life Sciences, Beijing, China; Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, ChinaMinistry of Education Key Laboratory of Protein Science, Tsinghua-Peking Joint Center for Life Sciences, Beijing, China; Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, ChinaMinistry of Education Key Laboratory of Protein Science, Tsinghua-Peking Joint Center for Life Sciences, Beijing, China; Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China; Corresponding author. Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, 30, Shuang Qing Rd., Haidian District, Beijing 100084, China.Respiration is one of the most vital and basic features of living organisms. In mammals, respiration is accomplished by respiratory chain complexes located on the mitochondrial inner membrane. In the past century, scientists put tremendous efforts in understanding these complexes, but failed to solve the high resolution structure until recently. In 2016, three research groups reported the structure of respiratory chain supercomplex from different species, and fortunately the structure solved by our group has the highest resolution. In this review, we will compare the recently solved structures of respirasome, probe into the relationship between cristae shape and respiratory chain organization, and discuss the highly disputed issues afterwards. Besides, our group reported the first high resolution structure of respirasome and medium resolution structure of megacomplex from cultured human cells this year. Definitely, these supercomplex structures will provide precious information for conquering the mitochondrial malfunction diseases. Keywords: Structure of respirasome, Cristae organization, Substrate channeling, Electron transfer pathway, Assembly of respirasomehttp://www.sciencedirect.com/science/article/pii/S2319417017303025 |
| spellingShingle | Runyu Guo Jinke Gu Shuai Zong Meng Wu Maojun Yang Structure and mechanism of mitochondrial electron transport chain Biomedical Journal |
| title | Structure and mechanism of mitochondrial electron transport chain |
| title_full | Structure and mechanism of mitochondrial electron transport chain |
| title_fullStr | Structure and mechanism of mitochondrial electron transport chain |
| title_full_unstemmed | Structure and mechanism of mitochondrial electron transport chain |
| title_short | Structure and mechanism of mitochondrial electron transport chain |
| title_sort | structure and mechanism of mitochondrial electron transport chain |
| url | http://www.sciencedirect.com/science/article/pii/S2319417017303025 |
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