Sex differences in the associations of body size and body shape with platelets in the UK Biobank cohort

Highlights We examined a large middle-aged population-based cohort, excluding participants with prevalent cancer, endocrine and metabolic conditions, and severe illnesses. Body mass index (BMI) was associated positively with platelet count in women (strongest in pre-menopausal women) and inversely i...

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Bibliographic Details
Main Authors: Sofia Christakoudi, Konstantinos K. Tsilidis, Evangelos Evangelou, Elio Riboli
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Biology of Sex Differences
Subjects:
Online Access:https://doi.org/10.1186/s13293-023-00494-y
Description
Summary:Highlights We examined a large middle-aged population-based cohort, excluding participants with prevalent cancer, endocrine and metabolic conditions, and severe illnesses. Body mass index (BMI) was associated positively with platelet count in women (strongest in pre-menopausal women) and inversely in men (strongest in older men), but inversely with platelet size in pre-menopausal women and positively in post-menopausal women and men. Alcohol consumption and smoking shifted the association of BMI with platelet count towards the null for women and towards a stronger inverse association for men, but did not affect the associations with waist or hip size. Waist size was associated positively with platelet count in women and men, with only a weak inverse association for hip size. Waist size was associated inversely and hip size positively with platelet size, mainly in women.
ISSN:2042-6410