INFERIOR LIP SPINOCELLULAR CARCINOMA ETIOLOGIC FACTORS-NOVEL ETIOLOGIC ASPECTS CASE REPORT
Introduction Squamous cell carcinoma of the lower lip represents 90% of all oral cancers and its incidence is increasing. Material and methods Our study focuses on two cases of patients with carcinoma of the lower lip, both men: first case, an 68 years old man, with chronic alcohol consumption, sm...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Romanian Society of Oral Rehabilitation
2015-01-01
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| Series: | Romanian Journal of Oral Rehabilitation |
| Subjects: | |
| Online Access: | http://www.rjor.ro/inferior-lip-spinocellular-carcinoma-etiologic-factors-novel-etiologic-aspects-case-report/?lang=ro |
| Summary: | Introduction Squamous cell carcinoma of the lower lip represents 90% of all oral cancers and its incidence is
increasing. Material and methods Our study focuses on two cases of patients with carcinoma of the lower lip,
both men: first case, an 68 years old man, with chronic alcohol consumption, smoker (2 packs / day over 30
years), with partial edentation, from rural area, under chronic intermittent Miofilin treatment for COPD
underwent a wide excision in the lower lip for ulcerative squamous cell carcinoma confirmed histologically.
Risk factors in this case are: male, age over 50 years, chronic smoking, alcohol consumption, prolonged sun
exposure, lack of dental care. The second case, a man of 42 years, urban area, with occasionally consumption of
alcohol, ex-smoker, with no comorbidities, is diagnosed with squamous cell carcinoma of the lower lip,
infiltrative form, confirmed histologically after excision of large tumor. HPV (Human Papilloma Virus) DNA
was detected in the cells obtained by the scraper of the oral mucosa through PCR amplification techniques.
Etipatogenic factors in this case are: males, HPV infection. Results and conclusions A careful review of the
factors involved in the etiopathogenesis of the lower lip squamous cell carcinoma include: exposure to
ultraviolet rays in the elderly (intermaxillary distance is reduced gradually due to dentition changes causing
vermillion's protrusion of the lower lip and thus favoring prolonged contact with carcinogens – UV rays,
cigarette/cigar); chronic alcohol consumption; smoking at a young age; poor oral hygiene; partial or temporary
edentation; Helicobacter pylori - recently isolated from dental plaque, the dorsal tongue and the inner lip; HPV
infection; xeroderma pigmentosum |
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| ISSN: | 2066-7000 2601-4661 |