Identification of 4-Amino-Thieno[2,3-<italic toggle="yes">d</italic>]Pyrimidines as QcrB Inhibitors in <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content>

Identification of 4-Amino-Thieno[2,3-<italic toggle="yes">d</italic>]Pyrimidines as QcrB Inhibitors in <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content>

ABSTRACT Antibiotic resistance is a global crisis that threatens our ability to treat bacterial infections, such as tuberculosis, caused by Mycobacterium tuberculosis. Of the 10 million cases of tuberculosis in 2017, approximately 19% of new cases and 43% of previously treated cases were caused by s...

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Bibliographic Details
Main Authors: Gregory A. Harrison, Anne E. Mayer Bridwell, Megh Singh, Keshav Jayaraman, Leslie A. Weiss, Rachel L. Kinsella, Janessa S. Aneke, Kelly Flentie, Miranda E. Schene, Margaret Gaggioli, Samantha D. Solomon, Scott A. Wildman, Marvin J. Meyers, Christina L. Stallings
Format: Article
Language:English
Published: American Society for Microbiology 2019-10-01
Series:mSphere
Subjects:
CydAB
Mycobacterium tuberculosis
QcrB
antibiotic
cytochrome
drug discovery
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00606-19

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