Cerebrospinal fluid neurofilament light chains and CXCL13 as predictive factors for clinical course of multiple sclerosis
Aim. The aim of this study was to identify whether NfL and CXCL13 cerebrospinal fluid (CSF) concentrations at diagnostic lumbar puncture can predict the course of multiple sclerosis (MS) in terms of relapses, higher expanded disability status scale (EDSS) and magnetic resonance imaging (MRI) activit...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Palacký University Olomouc, Faculty of Medicine and Dentistry
2023-03-01
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| Series: | Biomedical Papers |
| Subjects: | |
| Online Access: | https://biomed.papers.upol.cz/artkey/bio-202301-0005_cerebrospinal-fluid-neurofilament-light-chains-and-cxcl13-as-predictive-factors-for-clinical-course-of-multiple.php |
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| author | Pavel Hradilek Kamila Zondra Revendova Jana Horakova Radovan Bunganic Ondrej Pelisek David Zeman Pavla Hanzlikova Pavlina Kusnierova |
| author_facet | Pavel Hradilek Kamila Zondra Revendova Jana Horakova Radovan Bunganic Ondrej Pelisek David Zeman Pavla Hanzlikova Pavlina Kusnierova |
| author_sort | Pavel Hradilek |
| collection | DOAJ |
| description | Aim. The aim of this study was to identify whether NfL and CXCL13 cerebrospinal fluid (CSF) concentrations at diagnostic lumbar puncture can predict the course of multiple sclerosis (MS) in terms of relapses, higher expanded disability status scale (EDSS) and magnetic resonance imaging (MRI) activity. Methods. We conducted a single-centre prospective observational cohort study at the MS center, University Hospital Ostrava, Czech Republic. CSF NfL (cNfL) and CXCL13 concentrations were examined (ELISA method) in patients with clinically isolated syndrome (CIS) and relapsing-remitting MS (RRMS) at the time of diagnostic lumbar puncture. Results. A total of 44 patients with CIS or early RRMS were enrolled, 31 (70.5%) of whom were women. The median age at the time of CSF sampling was 31.21 years (IQR 25.43-39.32), and the follow-up period was 54.6 months (IQR 44.03-59.48). In the simple and multiple logistic regression models, CXCL13 levels did not predict relapses, MRI activity or EDSS > 2.5. Similarly, cNfL concentrations did not predict relapses or MRI activity in either model. In the multiple regression, higher cNfL levels were associated with reaching EDSS > 2.5 (odds ratio [OR] 1.002, 95% confidence interval [CI] 1.000 to 1.003). Conclusions. Our data did not confirm cNfL and/or CXCL13 CSF levels were predictive factors for disease activity such as relapses and MRI activity at the time of diagnostic lumbar puncture in patients with RRMS. While cNfL CSF levels predicted higher disability only after adjustment for other known risk factors, elevated CSF CXCL13 did not predict higher disability at all. |
| first_indexed | 2024-04-09T14:54:32Z |
| format | Article |
| id | doaj.art-ad186c4a3e0d4e1f8ea520ddeff4aab0 |
| institution | Directory Open Access Journal |
| issn | 1213-8118 1804-7521 |
| language | English |
| last_indexed | 2024-04-09T14:54:32Z |
| publishDate | 2023-03-01 |
| publisher | Palacký University Olomouc, Faculty of Medicine and Dentistry |
| record_format | Article |
| series | Biomedical Papers |
| spelling | doaj.art-ad186c4a3e0d4e1f8ea520ddeff4aab02023-05-02T08:04:03ZengPalacký University Olomouc, Faculty of Medicine and DentistryBiomedical Papers1213-81181804-75212023-03-011671303510.5507/bp.2023.002bio-202301-0005Cerebrospinal fluid neurofilament light chains and CXCL13 as predictive factors for clinical course of multiple sclerosisPavel Hradilek0Kamila Zondra Revendova1Jana Horakova2Radovan Bunganic3Ondrej Pelisek4David Zeman5Pavla Hanzlikova6Pavlina Kusnierova7Department of Clinical Neurosciences, Faculty of Medicine, University of Ostrava, Ostrava, Czech RepublicDepartment of Clinical Neurosciences, Faculty of Medicine, University of Ostrava, Ostrava, Czech RepublicDepartment of Neurology, University Hospital Ostrava, Ostrava, Czech RepublicDepartment of Clinical Neurosciences, Faculty of Medicine, University of Ostrava, Ostrava, Czech RepublicFaculty of Medicine, Masaryk University, Brno, Czech RepublicDepartment of Laboratory Medicine, University Hospital Brno, Brno, Czech RepublicDepartment of Imaging Methods, Faculty of Medicine, University of Ostrava, Ostrava, Czech RepublicDepartment of Clinical Biochemistry, Institute of Laboratory Medicine, University Hospital Ostrava, Ostrava, Czech RepublicAim. The aim of this study was to identify whether NfL and CXCL13 cerebrospinal fluid (CSF) concentrations at diagnostic lumbar puncture can predict the course of multiple sclerosis (MS) in terms of relapses, higher expanded disability status scale (EDSS) and magnetic resonance imaging (MRI) activity. Methods. We conducted a single-centre prospective observational cohort study at the MS center, University Hospital Ostrava, Czech Republic. CSF NfL (cNfL) and CXCL13 concentrations were examined (ELISA method) in patients with clinically isolated syndrome (CIS) and relapsing-remitting MS (RRMS) at the time of diagnostic lumbar puncture. Results. A total of 44 patients with CIS or early RRMS were enrolled, 31 (70.5%) of whom were women. The median age at the time of CSF sampling was 31.21 years (IQR 25.43-39.32), and the follow-up period was 54.6 months (IQR 44.03-59.48). In the simple and multiple logistic regression models, CXCL13 levels did not predict relapses, MRI activity or EDSS > 2.5. Similarly, cNfL concentrations did not predict relapses or MRI activity in either model. In the multiple regression, higher cNfL levels were associated with reaching EDSS > 2.5 (odds ratio [OR] 1.002, 95% confidence interval [CI] 1.000 to 1.003). Conclusions. Our data did not confirm cNfL and/or CXCL13 CSF levels were predictive factors for disease activity such as relapses and MRI activity at the time of diagnostic lumbar puncture in patients with RRMS. While cNfL CSF levels predicted higher disability only after adjustment for other known risk factors, elevated CSF CXCL13 did not predict higher disability at all.https://biomed.papers.upol.cz/artkey/bio-202301-0005_cerebrospinal-fluid-neurofilament-light-chains-and-cxcl13-as-predictive-factors-for-clinical-course-of-multiple.phpmultiple sclerosisbiomarkersneurofilament light chaincxcl13clinical course |
| spellingShingle | Pavel Hradilek Kamila Zondra Revendova Jana Horakova Radovan Bunganic Ondrej Pelisek David Zeman Pavla Hanzlikova Pavlina Kusnierova Cerebrospinal fluid neurofilament light chains and CXCL13 as predictive factors for clinical course of multiple sclerosis Biomedical Papers multiple sclerosis biomarkers neurofilament light chain cxcl13 clinical course |
| title | Cerebrospinal fluid neurofilament light chains and CXCL13 as predictive factors for clinical course of multiple sclerosis |
| title_full | Cerebrospinal fluid neurofilament light chains and CXCL13 as predictive factors for clinical course of multiple sclerosis |
| title_fullStr | Cerebrospinal fluid neurofilament light chains and CXCL13 as predictive factors for clinical course of multiple sclerosis |
| title_full_unstemmed | Cerebrospinal fluid neurofilament light chains and CXCL13 as predictive factors for clinical course of multiple sclerosis |
| title_short | Cerebrospinal fluid neurofilament light chains and CXCL13 as predictive factors for clinical course of multiple sclerosis |
| title_sort | cerebrospinal fluid neurofilament light chains and cxcl13 as predictive factors for clinical course of multiple sclerosis |
| topic | multiple sclerosis biomarkers neurofilament light chain cxcl13 clinical course |
| url | https://biomed.papers.upol.cz/artkey/bio-202301-0005_cerebrospinal-fluid-neurofilament-light-chains-and-cxcl13-as-predictive-factors-for-clinical-course-of-multiple.php |
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