A Single Dose of Anti-HBsAg Antibody-Encoding mRNA-LNPs Suppressed HBsAg Expression: a Potential Cure of Chronic Hepatitis B Virus Infection

A Single Dose of Anti-HBsAg Antibody-Encoding mRNA-LNPs Suppressed HBsAg Expression: a Potential Cure of Chronic Hepatitis B Virus Infection

ABSTRACT Hepatitis B virus (HBV) infection is a serious global health issue with more than 250 million chronic carriers. It causes liver diseases such as chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma (HCC). Persistent suppression of the HBV surface antigen (HBsAg) is necessary for...

Full description

Bibliographic Details
Main Authors:	Binfan Chen, Yuchen Chen, Jian Li, Chunyu Wang, Wenping Song, Yumei Wen, Jinzhong Lin, Yanling Wu, Tianlei Ying
Format:	Article
Language:	English
Published:	American Society for Microbiology 2022-08-01
Series:	mBio
Subjects:	HBV infection HBsAg functional cure immune response antibody mRNA
Online Access:	https://journals.asm.org/doi/10.1128/mbio.01612-22

Similar Items

Clinical cure rate of inactive HBsAg carriers with HBsAg <200 IU/ml treated with pegylated interferon
by: Hong Li, et al.
Published: (2022-12-01)

Performance Evaluation of an Improved HBsAg Assay (HBsAg NEXT) for the Detection of HBsAg Levels
by: Ekta Gupta, et al.
Published: (2023-12-01)

Unexpected rise in the circulation of complex HBV variants enriched of HBsAg vaccine-escape mutations in HBV genotype-D: potential impact on HBsAg detection/quantification and vaccination strategies
by: Lorenzo Piermatteo, et al.
Published: (2023-12-01)

HBsAg in Cord Blood Qf Newborns of HBsAg-Positive Mothers
by: Adnan S. Wiharta, et al.
Published: (2018-11-01)

Key mutations in the C-terminus of the HBV surface glycoprotein correlate with lower HBsAg levels in vivo, hinder HBsAg secretion in vitro and reduce HBsAg structural stability in the setting of HBeAg-negative chronic HBV genotype-D infection
by: Romina Salpini, et al.
Published: (2020-01-01)

Investigation of HBV DNA in HBsAg positive patients
by: Nihal Secil Bati, et al.
Published: (2017-12-01)

Prediction for HBsAg seroconversion in children with chronic hepatitis B
by: Yan-Wei Zhong, et al.
Published: (2021-12-01)

Geographic distribution of HBsAg subtypes in Brazil Distribuição geográfica dos subtipos de antígenos de HBsAg no Brasil
by: Ana Maria Coimbra Gaspar, et al.
Published: (1987-06-01)

Detection of S-HBsAg Mutations in Patients with Hematologic Malignancies
by: Maria V. Konopleva, et al.
Published: (2021-05-01)

Pre-transplant donor HBV DNA+ and male recipient are independent risk factors for treatment failure in HBsAg+ donors to HBsAg- kidney transplant recipients
by: Xian-ding Wang, et al.
Published: (2021-01-01)

Accuracy Validation of the Elecsys HBsAg II Quant Assay and Its Utility in Resolving Equivocal Qualitative HBsAg Results
by: Jaehyeon Lee, et al.
Published: (2023-02-01)

Performance of rapid test in detection of HBsAg in frozen sera
by: Firat Zafer Mengeloglu, et al.
Published: (2014-03-01)

HBsAg Loss as a Treatment Endpoint for Chronic HBV Infection: HBV Cure
by: Maryam Moini, et al.
Published: (2022-03-01)

Analysis of S gene characteristic sequences and changes in properties of protein expression in HBV ASCs with low-level HBsAg
by: Yu Yu, et al.
Published: (2022-09-01)

An optimized mode of interferon intermittent therapy help improve HBsAg disappearance in chronic hepatitis B patients
by: Minghui Li, et al.
Published: (2022-08-01)

HIGH PREVALENCE OF HBsAg CARRIERS IN A SPECIFIC COMMUNITY IN BULGARIA
by: Zahariy Krastev, et al.
Published: (2011-10-01)

Seromarkers of Hepatitis B virus in newborns with HBsAg positive mothers
by: Yousef Yahyapour (PhD), et al.
Published: (2009-05-01)

Impact of HBcrAg levels on HBsAg seroconversion after HBV rebound: a case report
by: Maki Ohkubo, et al.
Published: (2023-12-01)

HBsAg protein composition and clinical outcomes in chronic hepatitis D and variations across HBeAg-negative chronic HBsAg carriers
by: Luisa Roade, et al.
Published: (2023-10-01)

Analytical Performance of the Sysmex HISCL HBsAg Assay and Comparison with the Roche Elecsys HBsAg II Quant Assay in the Quantification of Hepatitis B Surface Antigen
by: Joonhong Park, et al.
Published: (2021-11-01)

Long-Term HBsAg Titer Kinetics with Entecavir/Tenofovir: Implications for Predicting Functional Cure and Low Levels
by: Soon Kyu Lee, et al.
Published: (2024-02-01)

Is Quantitative HBsAg Measurement a Reliable Substitute for HBV DNA Quantitation?
by: Mohammad Reza Mahdavi, et al.
Published: (2015-07-01)

Circulating immune complexes and mutations of HBsAg are associated with the undetectable HBsAg in anti-HBs and HBeAg positive occult hepatitis B virus infection
by: Ying Yan, et al.
Published: (2022-11-01)

Using the Quantitative Determination of HbsAg to Monitor Antiviral Therapy of Chronic HBV-Infection
by: I.A. Zaitsev
Published: (2015-04-01)

Frequency of HBsAg in pregnant women in Gorgan, Iran
by: Cheraghali F (MD), et al.
Published: (2012-01-01)

The occurrence of immune-related adverse events is an independent risk factor both for serum HBsAg increase and HBV reactivation in HBsAg-positive cancer patients receiving PD-1 inhibitor combinational therapy
by: Yingfu Zeng, et al.
Published: (2024-03-01)

End-of-treatment anti-HBs levels and HBeAg status identify durability of HBsAg loss after PEG-IFN discontinuation
by: Yifei Guo, et al.
Published: (2023-02-01)

Longitudinal characterization of phenotypic profile of T cells in chronic hepatitis B identifies immune markers associated with HBsAg loss
by: Shue Xiong, et al.
Published: (2021-07-01)

ADCC-Mediated CD56dim NK Cell Responses Are Associated with Early HBsAg Clearance in Acute HBV Infection
by: Wen-Han Yu, et al.
Published: (2018-02-01)

PEMERIKSAAN HEPATITIS B SURFACE ANTIGEN (HBsAg) DAN Anti-HBs PADA IBU HAMIL
by: Herlando Sinaga, et al.
Published: (2018-12-01)

Detection and prevalence of HBsAg and HBV DNA among visiting patients attending health facilities in Nigeria
by: Uchenna D. Abazuh, et al.
Published: (2023-07-01)

The potential effect of HBV vaccination on off-treatment HBsAg reversion after interferon-induced HBsAg clearance
by: Shaowen Jiang, et al.
Published: (2023-01-01)

Expression of HBsAg Gene in Insect (Trichiplusia ni) Cell Culture
by: Mehmet YAPAR, et al.
Published: (2001-06-01)

Is there an association between the measurement of qualitative HBsAg and virologic response in chronic HBV infection?
by: Akif Altinbas, et al.
Published: (2012-05-01)

The presence of baseline HBsAb-Specific B cells can predict HBsAg or HBeAg seroconversion of chronic hepatitis B on treatment
by: Shengxia Yin, et al.
Published: (2023-12-01)

Clinical implications of HBsAg quantification in patients with chronic hepatitis B
by: Mauro Viganò, et al.
Published: (2012-01-01)

Incidência pós-transfusional do HBsAg em crianças com doenças neoplásicas Post-transfusional incidence of HBsAg in children with neoplastic diseases
by: Maria Zélia Fernandes, et al.
Published: (2009-04-01)

A comparison on HBsAg and HBsAb prevalence in patients with Down syndrome and other mentally retarded patients living in retarded children institutes in Tehran
by: Sahebjamei M. Associate Professor, et al.
Published: (2003-06-01)

Performance evaluation of the Access HBsAg and Access HBsAg confirmatory assays on the DxI 9000 Access Immunoassay Analyzer
by: Benoit Visseaux, et al.
Published: (2024-03-01)

Short-Term Peg-IFN α-2b Re-Treatment Induced a High Functional Cure Rate in Patients with HBsAg Recurrence after Stopping Peg-IFN α-Based Regimens
by: Fengping Wu, et al.
Published: (2023-01-01)