Flt3L therapy increases the abundance of Treg-promoting CCR7+ cDCs in preclinical cancer models

Flt3L therapy increases the abundance of Treg-promoting CCR7+ cDCs in preclinical cancer models

Conventional dendritic cells (cDCs) are at the forefront of activating the immune system to mount an anti-tumor immune response. Flt3L is a cytokine required for DC development that can increase DC abundance in the tumor when administered therapeutically. However, the impact of Flt3L on the phenotyp...

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Bibliographic Details
Main Authors: Emile J. Clappaert, Daliya Kancheva, Jan Brughmans, Ayla Debraekeleer, Pauline M. R. Bardet, Yvon Elkrim, Dagmar Lacroix, Maida Živalj, Ahmed E.I. Hamouda, Jo A. Van Ginderachter, Sofie Deschoemaeker, Damya Laoui
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Immunology
Subjects:
dendritic cell
immunotherapy
breast cancer
Flt3L
combination therapies
lung cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1166180/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1166180/full

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