PBP Target Profiling by β-Lactam and β-Lactamase Inhibitors in Intact Pseudomonas aeruginosa: Effects of the Intrinsic and Acquired Resistance Determinants on the Periplasmic Drug Availability

PBP Target Profiling by β-Lactam and β-Lactamase Inhibitors in Intact Pseudomonas aeruginosa: Effects of the Intrinsic and Acquired Resistance Determinants on the Periplasmic Drug Availability

ABSTRACT The lack of effective treatment options against Pseudomonas aeruginosa is one of the main contributors to the silent pandemic. Many antibiotics are ineffective against resistant isolates due to poor target site penetration, efflux, or β-lactamase hydrolysis. Critical insights to design opti...

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Bibliographic Details
Main Authors: Maria Montaner, Silvia Lopez-Argüello, Antonio Oliver, Bartolome Moya
Format: Article
Language:English
Published: American Society for Microbiology 2023-02-01
Series:Microbiology Spectrum
Subjects:
penicillin-binding proteins (PBP)
intact cells
Pseudomonas aeruginosa
outer membrane penetration
bacterial permeability
β-lactams
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03038-22

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