| Summary: | <i>Nocardioides</i>, a genus belonging to <i>Actinomycetes</i>, can endure various low-nutrient conditions. It can degrade pollutants using multiple organic materials such as carbon and nitrogen sources. The characteristics and applications of <i>Nocardioides</i> are described in detail in this review, with emphasis on the degradation of several hard-to-degrade pollutants by using <i>Nocardioides</i>, including aromatic compounds, hydrocarbons, haloalkanes, nitrogen heterocycles, and polymeric polyesters. <i>Nocardioides</i> has unique advantages when it comes to hard-to-degrade pollutants. Compared to other strains, <i>Nocardioides</i> has a significantly higher degradation rate and requires less time to break down substances. This review can be a theoretical basis for developing <i>Nocardioides</i> as a microbial agent with significant commercial and application potential.
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