Posttranslational regulation of the GCN5 and PCAF acetyltransferases.
General control nonderepressible 5 protein (Gcn5) and its homologs, including p300/CBP-associated factor (PCAF), are lysine acetyltransferases that modify both histone and non-histone proteins using acetyl coenzyme A as a donor substrate. While decades of studies have uncovered a vast network of cel...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-09-01
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| Series: | PLoS Genetics |
| Online Access: | https://doi.org/10.1371/journal.pgen.1010352 |
| _version_ | 1817979533466271744 |
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| author | Onyekachi E Ononye Michael Downey |
| author_facet | Onyekachi E Ononye Michael Downey |
| author_sort | Onyekachi E Ononye |
| collection | DOAJ |
| description | General control nonderepressible 5 protein (Gcn5) and its homologs, including p300/CBP-associated factor (PCAF), are lysine acetyltransferases that modify both histone and non-histone proteins using acetyl coenzyme A as a donor substrate. While decades of studies have uncovered a vast network of cellular processes impacted by these acetyltransferases, including gene transcription and metabolism, far less is known about how these enzymes are themselves regulated. In this review, we summarize the type and functions of posttranslational modifications proposed to control Gcn5 in both yeast and human cells. We further outline common themes, open questions, and strategies to guide future work. |
| first_indexed | 2024-04-13T22:42:51Z |
| format | Article |
| id | doaj.art-ad1bc8df57eb452e99e37daed635ca70 |
| institution | Directory Open Access Journal |
| issn | 1553-7390 1553-7404 |
| language | English |
| last_indexed | 2024-04-13T22:42:51Z |
| publishDate | 2022-09-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Genetics |
| spelling | doaj.art-ad1bc8df57eb452e99e37daed635ca702022-12-22T02:26:31ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042022-09-01189e101035210.1371/journal.pgen.1010352Posttranslational regulation of the GCN5 and PCAF acetyltransferases.Onyekachi E OnonyeMichael DowneyGeneral control nonderepressible 5 protein (Gcn5) and its homologs, including p300/CBP-associated factor (PCAF), are lysine acetyltransferases that modify both histone and non-histone proteins using acetyl coenzyme A as a donor substrate. While decades of studies have uncovered a vast network of cellular processes impacted by these acetyltransferases, including gene transcription and metabolism, far less is known about how these enzymes are themselves regulated. In this review, we summarize the type and functions of posttranslational modifications proposed to control Gcn5 in both yeast and human cells. We further outline common themes, open questions, and strategies to guide future work.https://doi.org/10.1371/journal.pgen.1010352 |
| spellingShingle | Onyekachi E Ononye Michael Downey Posttranslational regulation of the GCN5 and PCAF acetyltransferases. PLoS Genetics |
| title | Posttranslational regulation of the GCN5 and PCAF acetyltransferases. |
| title_full | Posttranslational regulation of the GCN5 and PCAF acetyltransferases. |
| title_fullStr | Posttranslational regulation of the GCN5 and PCAF acetyltransferases. |
| title_full_unstemmed | Posttranslational regulation of the GCN5 and PCAF acetyltransferases. |
| title_short | Posttranslational regulation of the GCN5 and PCAF acetyltransferases. |
| title_sort | posttranslational regulation of the gcn5 and pcaf acetyltransferases |
| url | https://doi.org/10.1371/journal.pgen.1010352 |
| work_keys_str_mv | AT onyekachieononye posttranslationalregulationofthegcn5andpcafacetyltransferases AT michaeldowney posttranslationalregulationofthegcn5andpcafacetyltransferases |