Optimal time and threshold of absolute lymphocyte count recovery as a prognostic factor after single‐unit cord blood transplantation in adults
Abstract We retrospectively evaluated the optimal time and threshold of absolute lymphocyte count (ALC) recovery as a prognostic factor in 174 adult patients who received single‐unit cord blood transplantation (CBT) at our institute. We analyzed the impact of ALC ≥300, ≥600, and ≥900/μl by 30 and 60...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-02-01
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| Series: | eJHaem |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/jha2.372 |
| _version_ | 1797740061349904384 |
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| author | Takaaki Konuma Maki Monna‐Oiwa Kosuke Takano Masamichi Isobe Seiko Kato Satoshi Takahashi Yasuhito Nannya |
| author_facet | Takaaki Konuma Maki Monna‐Oiwa Kosuke Takano Masamichi Isobe Seiko Kato Satoshi Takahashi Yasuhito Nannya |
| author_sort | Takaaki Konuma |
| collection | DOAJ |
| description | Abstract We retrospectively evaluated the optimal time and threshold of absolute lymphocyte count (ALC) recovery as a prognostic factor in 174 adult patients who received single‐unit cord blood transplantation (CBT) at our institute. We analyzed the impact of ALC ≥300, ≥600, and ≥900/μl by 30 and 60 days on transplant outcomes. Multivariate analysis showed that only ALC ≥300/μl at 60 days was significantly associated with overall mortality (hazard ratio, 0.24; p = 0.001) following CBT. The optimal time point to use ALC recovery as a prognostic tool following CBT could be later than those following adult donor transplantation. |
| first_indexed | 2024-03-12T14:06:54Z |
| format | Article |
| id | doaj.art-ad1fb59a68434c40b2ab6e2965ca3389 |
| institution | Directory Open Access Journal |
| issn | 2688-6146 |
| language | English |
| last_indexed | 2024-03-12T14:06:54Z |
| publishDate | 2022-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | eJHaem |
| spelling | doaj.art-ad1fb59a68434c40b2ab6e2965ca33892023-08-21T14:05:38ZengWileyeJHaem2688-61462022-02-013119119810.1002/jha2.372Optimal time and threshold of absolute lymphocyte count recovery as a prognostic factor after single‐unit cord blood transplantation in adultsTakaaki Konuma0Maki Monna‐Oiwa1Kosuke Takano2Masamichi Isobe3Seiko Kato4Satoshi Takahashi5Yasuhito Nannya6Department of Hematology/Oncology The Institute of Medical Science The University of Tokyo Tokyo JapanDepartment of Hematology/Oncology The Institute of Medical Science The University of Tokyo Tokyo JapanDepartment of Hematology/Oncology The Institute of Medical Science The University of Tokyo Tokyo JapanDepartment of Hematology/Oncology The Institute of Medical Science The University of Tokyo Tokyo JapanDepartment of Hematology/Oncology The Institute of Medical Science The University of Tokyo Tokyo JapanDepartment of Hematology/Oncology The Institute of Medical Science The University of Tokyo Tokyo JapanDepartment of Hematology/Oncology The Institute of Medical Science The University of Tokyo Tokyo JapanAbstract We retrospectively evaluated the optimal time and threshold of absolute lymphocyte count (ALC) recovery as a prognostic factor in 174 adult patients who received single‐unit cord blood transplantation (CBT) at our institute. We analyzed the impact of ALC ≥300, ≥600, and ≥900/μl by 30 and 60 days on transplant outcomes. Multivariate analysis showed that only ALC ≥300/μl at 60 days was significantly associated with overall mortality (hazard ratio, 0.24; p = 0.001) following CBT. The optimal time point to use ALC recovery as a prognostic tool following CBT could be later than those following adult donor transplantation.https://doi.org/10.1002/jha2.372absolute lymphocyte countallogeneic hematopoietic cell transplantationcord blood transplantationimmune reconstitutionnon‐relapse mortalitysurvival |
| spellingShingle | Takaaki Konuma Maki Monna‐Oiwa Kosuke Takano Masamichi Isobe Seiko Kato Satoshi Takahashi Yasuhito Nannya Optimal time and threshold of absolute lymphocyte count recovery as a prognostic factor after single‐unit cord blood transplantation in adults eJHaem absolute lymphocyte count allogeneic hematopoietic cell transplantation cord blood transplantation immune reconstitution non‐relapse mortality survival |
| title | Optimal time and threshold of absolute lymphocyte count recovery as a prognostic factor after single‐unit cord blood transplantation in adults |
| title_full | Optimal time and threshold of absolute lymphocyte count recovery as a prognostic factor after single‐unit cord blood transplantation in adults |
| title_fullStr | Optimal time and threshold of absolute lymphocyte count recovery as a prognostic factor after single‐unit cord blood transplantation in adults |
| title_full_unstemmed | Optimal time and threshold of absolute lymphocyte count recovery as a prognostic factor after single‐unit cord blood transplantation in adults |
| title_short | Optimal time and threshold of absolute lymphocyte count recovery as a prognostic factor after single‐unit cord blood transplantation in adults |
| title_sort | optimal time and threshold of absolute lymphocyte count recovery as a prognostic factor after single unit cord blood transplantation in adults |
| topic | absolute lymphocyte count allogeneic hematopoietic cell transplantation cord blood transplantation immune reconstitution non‐relapse mortality survival |
| url | https://doi.org/10.1002/jha2.372 |
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