MicroRNA Alteration, Application as Biomarkers, and Therapeutic Approaches in Neurodegenerative Diseases
MicroRNAs (miRNAs) are essential post-transcriptional gene regulators involved in various neuronal and non-neuronal cell functions and play a key role in pathological conditions. Numerous studies have demonstrated that miRNAs are dysregulated in major neurodegenerative diseases, such as Alzheimer’s...
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MDPI AG
2022-04-01
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Online Access: | https://www.mdpi.com/1422-0067/23/9/4718 |
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author | T. P. Nhung Nguyen Mandeep Kumar Ernesto Fedele Giambattista Bonanno Tiziana Bonifacino |
author_facet | T. P. Nhung Nguyen Mandeep Kumar Ernesto Fedele Giambattista Bonanno Tiziana Bonifacino |
author_sort | T. P. Nhung Nguyen |
collection | DOAJ |
description | MicroRNAs (miRNAs) are essential post-transcriptional gene regulators involved in various neuronal and non-neuronal cell functions and play a key role in pathological conditions. Numerous studies have demonstrated that miRNAs are dysregulated in major neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, amyotrophic lateral sclerosis, or Huntington’s disease. Hence, in the present work, we constructed a comprehensive overview of individual microRNA alterations in various models of the above neurodegenerative diseases. We also provided evidence of miRNAs as promising biomarkers for prognostic and diagnostic approaches. In addition, we summarized data from the literature about miRNA-based therapeutic applications via inhibiting or promoting miRNA expression. We finally identified the overlapping miRNA signature across the diseases, including miR-128, miR-140-5p, miR-206, miR-326, and miR-155, associated with multiple etiological cellular mechanisms. However, it remains to be established whether and to what extent miRNA-based therapies could be safely exploited in the future as effective symptomatic or disease-modifying approaches in the different human neurodegenerative disorders. |
first_indexed | 2024-03-10T04:06:30Z |
format | Article |
id | doaj.art-ad1fcededfe84766b43136579f9683db |
institution | Directory Open Access Journal |
issn | 1661-6596 1422-0067 |
language | English |
last_indexed | 2024-03-10T04:06:30Z |
publishDate | 2022-04-01 |
publisher | MDPI AG |
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series | International Journal of Molecular Sciences |
spelling | doaj.art-ad1fcededfe84766b43136579f9683db2023-11-23T08:21:15ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-04-01239471810.3390/ijms23094718MicroRNA Alteration, Application as Biomarkers, and Therapeutic Approaches in Neurodegenerative DiseasesT. P. Nhung Nguyen0Mandeep Kumar1Ernesto Fedele2Giambattista Bonanno3Tiziana Bonifacino4Pharmacology and Toxicology Unit, Department of Pharmacy, University of Genoa, Viale Cembrano 4, 16148 Genoa, ItalyPharmacology and Toxicology Unit, Department of Pharmacy, University of Genoa, Viale Cembrano 4, 16148 Genoa, ItalyPharmacology and Toxicology Unit, Department of Pharmacy, University of Genoa, Viale Cembrano 4, 16148 Genoa, ItalyPharmacology and Toxicology Unit, Department of Pharmacy, University of Genoa, Viale Cembrano 4, 16148 Genoa, ItalyPharmacology and Toxicology Unit, Department of Pharmacy, University of Genoa, Viale Cembrano 4, 16148 Genoa, ItalyMicroRNAs (miRNAs) are essential post-transcriptional gene regulators involved in various neuronal and non-neuronal cell functions and play a key role in pathological conditions. Numerous studies have demonstrated that miRNAs are dysregulated in major neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, amyotrophic lateral sclerosis, or Huntington’s disease. Hence, in the present work, we constructed a comprehensive overview of individual microRNA alterations in various models of the above neurodegenerative diseases. We also provided evidence of miRNAs as promising biomarkers for prognostic and diagnostic approaches. In addition, we summarized data from the literature about miRNA-based therapeutic applications via inhibiting or promoting miRNA expression. We finally identified the overlapping miRNA signature across the diseases, including miR-128, miR-140-5p, miR-206, miR-326, and miR-155, associated with multiple etiological cellular mechanisms. However, it remains to be established whether and to what extent miRNA-based therapies could be safely exploited in the future as effective symptomatic or disease-modifying approaches in the different human neurodegenerative disorders.https://www.mdpi.com/1422-0067/23/9/4718microRNAs (miRNAs)neurodegenerative diseasesAlzheimer’s disease (AD)amyotrophic lateral sclerosis (ALS)Parkinson’s disease (PD)multiple sclerosis (MS) |
spellingShingle | T. P. Nhung Nguyen Mandeep Kumar Ernesto Fedele Giambattista Bonanno Tiziana Bonifacino MicroRNA Alteration, Application as Biomarkers, and Therapeutic Approaches in Neurodegenerative Diseases International Journal of Molecular Sciences microRNAs (miRNAs) neurodegenerative diseases Alzheimer’s disease (AD) amyotrophic lateral sclerosis (ALS) Parkinson’s disease (PD) multiple sclerosis (MS) |
title | MicroRNA Alteration, Application as Biomarkers, and Therapeutic Approaches in Neurodegenerative Diseases |
title_full | MicroRNA Alteration, Application as Biomarkers, and Therapeutic Approaches in Neurodegenerative Diseases |
title_fullStr | MicroRNA Alteration, Application as Biomarkers, and Therapeutic Approaches in Neurodegenerative Diseases |
title_full_unstemmed | MicroRNA Alteration, Application as Biomarkers, and Therapeutic Approaches in Neurodegenerative Diseases |
title_short | MicroRNA Alteration, Application as Biomarkers, and Therapeutic Approaches in Neurodegenerative Diseases |
title_sort | microrna alteration application as biomarkers and therapeutic approaches in neurodegenerative diseases |
topic | microRNAs (miRNAs) neurodegenerative diseases Alzheimer’s disease (AD) amyotrophic lateral sclerosis (ALS) Parkinson’s disease (PD) multiple sclerosis (MS) |
url | https://www.mdpi.com/1422-0067/23/9/4718 |
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