Effect of antenatal Betamethasone on prevention of respiratory distress syndrome among neonates with gestational age of 35-36 weeks
Background and Objective: Respiratory distress syndrome is the most important lung problem during the neonatal period. Although the benefits of antenatal corticosteroids in neonates with a gestational age of less than 34 weeks have been demonstrated, the benefit of this treatment in neonates with hi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | fas |
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Golestan University of Medical Sciences
2010-09-01
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| Series: | مجله دانشگاه علوم پزشکی گرگان |
| Subjects: | |
| Online Access: | http://goums.ac.ir/journal/browse.php?a_code=A-10-1-454&slc_lang=en&sid=1 |
| _version_ | 1818541868287262720 |
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| author | Mansouri M (MD) Seyedolshohadaei F (MD) Company F (MD) Setare Sh (MD) Mazhari S (BSc) |
| author_facet | Mansouri M (MD) Seyedolshohadaei F (MD) Company F (MD) Setare Sh (MD) Mazhari S (BSc) |
| author_sort | Mansouri M (MD) |
| collection | DOAJ |
| description | Background and Objective: Respiratory distress syndrome is the most important lung problem during the neonatal period. Although the benefits of antenatal corticosteroids in neonates with a gestational age of less than 34 weeks have been demonstrated, the benefit of this treatment in neonates with higher gestational age is dubious. This study investigated the effect of Betamethasone on respiratory distress syndrome among neonates with gestational age of 35-36 weeks. Materials and Methods: This double blind randomized controlled trial study was done on 200 pregnant women who were of high risk for preterm labor in 35-36 weeks of gestation in Sanandaj city-Iran during 2007. 200 pregnant women randomly divided into treatment and placebo groups were received intramuscularly Betamethasone (12 mg/kg/BW twice) and normal saline, respectively. Data including age of mother, sex, weight, respiratory distress syndrome and newborns admission in hospital were recorded for each subject. Data was analyzed by using two-tailed T, Mann-Whitney, chi-square and Fisher exact tests. Results: There were no difference among two groups about age of mother, sex and weight of newborns. There were 8 (8%) and 20 (20%) newborns with respiratory distress syndrome in case and controls, respectively (P<0.01). Admission in hospital was 16% in Betamethasone group vs 28% in normal saline group (P<0.04). Conclusion: The study demonstrated that exposure to antenatal Betamethasone with 12mg/kg/BW twice between 35 and 36 weeks of gestation is associated with a significant reduction in the rate of respiratory distress syndrome. |
| first_indexed | 2024-12-11T22:14:47Z |
| format | Article |
| id | doaj.art-ad2085d0c60b48bca43a1222c38b63b8 |
| institution | Directory Open Access Journal |
| issn | 1562-4765 2008-4080 |
| language | fas |
| last_indexed | 2024-12-11T22:14:47Z |
| publishDate | 2010-09-01 |
| publisher | Golestan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشگاه علوم پزشکی گرگان |
| spelling | doaj.art-ad2085d0c60b48bca43a1222c38b63b82022-12-22T00:48:38ZfasGolestan University of Medical Sciencesمجله دانشگاه علوم پزشکی گرگان1562-47652008-40802010-09-011231823Effect of antenatal Betamethasone on prevention of respiratory distress syndrome among neonates with gestational age of 35-36 weeksMansouri M (MD)0Seyedolshohadaei F (MD)1Company F (MD)2Setare Sh (MD)3Mazhari S (BSc)4 Assistant Professor, Department of Pediatric, Kurdistan University of Medical Sciences, Sanandaj, Iran Assistant Professor, Department of Obstetric & Gynecology,Kurdistan University of Medical Sciences, Sanandaj, Iran Assistant Professor, Department of Pediatric, Kurdistan University of Medical Sciences, Sanandaj, Iran Resident of Pediatric, Kurdistan University of Medical Sciences, Sanandaj, Iran Midwifer, Kurdistan University of Medical Sciences, Sanandaj, Iran Background and Objective: Respiratory distress syndrome is the most important lung problem during the neonatal period. Although the benefits of antenatal corticosteroids in neonates with a gestational age of less than 34 weeks have been demonstrated, the benefit of this treatment in neonates with higher gestational age is dubious. This study investigated the effect of Betamethasone on respiratory distress syndrome among neonates with gestational age of 35-36 weeks. Materials and Methods: This double blind randomized controlled trial study was done on 200 pregnant women who were of high risk for preterm labor in 35-36 weeks of gestation in Sanandaj city-Iran during 2007. 200 pregnant women randomly divided into treatment and placebo groups were received intramuscularly Betamethasone (12 mg/kg/BW twice) and normal saline, respectively. Data including age of mother, sex, weight, respiratory distress syndrome and newborns admission in hospital were recorded for each subject. Data was analyzed by using two-tailed T, Mann-Whitney, chi-square and Fisher exact tests. Results: There were no difference among two groups about age of mother, sex and weight of newborns. There were 8 (8%) and 20 (20%) newborns with respiratory distress syndrome in case and controls, respectively (P<0.01). Admission in hospital was 16% in Betamethasone group vs 28% in normal saline group (P<0.04). Conclusion: The study demonstrated that exposure to antenatal Betamethasone with 12mg/kg/BW twice between 35 and 36 weeks of gestation is associated with a significant reduction in the rate of respiratory distress syndrome.http://goums.ac.ir/journal/browse.php?a_code=A-10-1-454&slc_lang=en&sid=1CorticosteroidsRespiratory distress syndromePreterm labor |
| spellingShingle | Mansouri M (MD) Seyedolshohadaei F (MD) Company F (MD) Setare Sh (MD) Mazhari S (BSc) Effect of antenatal Betamethasone on prevention of respiratory distress syndrome among neonates with gestational age of 35-36 weeks مجله دانشگاه علوم پزشکی گرگان Corticosteroids Respiratory distress syndrome Preterm labor |
| title | Effect of antenatal Betamethasone on prevention of respiratory distress syndrome among neonates with gestational age of 35-36 weeks |
| title_full | Effect of antenatal Betamethasone on prevention of respiratory distress syndrome among neonates with gestational age of 35-36 weeks |
| title_fullStr | Effect of antenatal Betamethasone on prevention of respiratory distress syndrome among neonates with gestational age of 35-36 weeks |
| title_full_unstemmed | Effect of antenatal Betamethasone on prevention of respiratory distress syndrome among neonates with gestational age of 35-36 weeks |
| title_short | Effect of antenatal Betamethasone on prevention of respiratory distress syndrome among neonates with gestational age of 35-36 weeks |
| title_sort | effect of antenatal betamethasone on prevention of respiratory distress syndrome among neonates with gestational age of 35 36 weeks |
| topic | Corticosteroids Respiratory distress syndrome Preterm labor |
| url | http://goums.ac.ir/journal/browse.php?a_code=A-10-1-454&slc_lang=en&sid=1 |
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