The underlying mechanism of Guillain-Barré syndrome in a young patient suffered from Japanese encephalitis virus infection: a case report
Abstract Background The presentation of Guillain–Barré syndrome (GBS) caused by Japanese encephalitis virus (JEV) is uncommon, although clusters of GBS cases were observed in China in 2018. The underlying mechanism is unclear, particularly in individuals vaccinated against Japanese encephalitis in c...
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| Format: | Article |
| Language: | English |
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BMC
2022-09-01
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| Series: | Virology Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12985-022-01870-7 |
| _version_ | 1798004523557453824 |
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| author | Sheng Liu Jinyong Wang Jun Yang Ying Wen |
| author_facet | Sheng Liu Jinyong Wang Jun Yang Ying Wen |
| author_sort | Sheng Liu |
| collection | DOAJ |
| description | Abstract Background The presentation of Guillain–Barré syndrome (GBS) caused by Japanese encephalitis virus (JEV) is uncommon, although clusters of GBS cases were observed in China in 2018. The underlying mechanism is unclear, particularly in individuals vaccinated against Japanese encephalitis in childhood. Case presentation We report a patient with acute flaccid paralysis involving four extremities and respiratory muscles, while magnetic resonance imaging of the brain and spine were standard. Electrophysiological examination displayed slowed motor nerve conduction speed and reduced evoked velocity amplitude. GBS was finally considered which was related to JEV infection verified by positive anti-JEV immunoglobulin M antibody and positive immunoglobulin G antibody in the serum. Unfortunately, the patient refused intravenous immunoglobulin and declined the use of mechanical ventilation again. He voluntarily withdrew from the hospital and died on the 36th day after the onset of illness. We also performed a review of previously reported related cases and discussed the underlying mechanism. Conclusion JEV infection-associated GBS is unusual. We should pay attention to the atypical manifestations of JEV infection and explore possible pathogenesis in particular individuals. |
| first_indexed | 2024-04-11T12:25:03Z |
| format | Article |
| id | doaj.art-ad21459e8da048e6b00fa4c251d7f737 |
| institution | Directory Open Access Journal |
| issn | 1743-422X |
| language | English |
| last_indexed | 2024-04-11T12:25:03Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Virology Journal |
| spelling | doaj.art-ad21459e8da048e6b00fa4c251d7f7372022-12-22T04:23:59ZengBMCVirology Journal1743-422X2022-09-011911510.1186/s12985-022-01870-7The underlying mechanism of Guillain-Barré syndrome in a young patient suffered from Japanese encephalitis virus infection: a case reportSheng Liu0Jinyong Wang1Jun Yang2Ying Wen3Department of Infectious Diseases, The First Affiliated Hospital of China Medical UniversityDepartment of Infectious Diseases, The First Affiliated Hospital of China Medical UniversityNeurology Department, The First Affiliated Hospital of China Medical UniversityDepartment of Infectious Diseases, The First Affiliated Hospital of China Medical UniversityAbstract Background The presentation of Guillain–Barré syndrome (GBS) caused by Japanese encephalitis virus (JEV) is uncommon, although clusters of GBS cases were observed in China in 2018. The underlying mechanism is unclear, particularly in individuals vaccinated against Japanese encephalitis in childhood. Case presentation We report a patient with acute flaccid paralysis involving four extremities and respiratory muscles, while magnetic resonance imaging of the brain and spine were standard. Electrophysiological examination displayed slowed motor nerve conduction speed and reduced evoked velocity amplitude. GBS was finally considered which was related to JEV infection verified by positive anti-JEV immunoglobulin M antibody and positive immunoglobulin G antibody in the serum. Unfortunately, the patient refused intravenous immunoglobulin and declined the use of mechanical ventilation again. He voluntarily withdrew from the hospital and died on the 36th day after the onset of illness. We also performed a review of previously reported related cases and discussed the underlying mechanism. Conclusion JEV infection-associated GBS is unusual. We should pay attention to the atypical manifestations of JEV infection and explore possible pathogenesis in particular individuals.https://doi.org/10.1186/s12985-022-01870-7Guillain-Barré syndromeJapanese encephalitis virusVaccinationPathogenesis |
| spellingShingle | Sheng Liu Jinyong Wang Jun Yang Ying Wen The underlying mechanism of Guillain-Barré syndrome in a young patient suffered from Japanese encephalitis virus infection: a case report Virology Journal Guillain-Barré syndrome Japanese encephalitis virus Vaccination Pathogenesis |
| title | The underlying mechanism of Guillain-Barré syndrome in a young patient suffered from Japanese encephalitis virus infection: a case report |
| title_full | The underlying mechanism of Guillain-Barré syndrome in a young patient suffered from Japanese encephalitis virus infection: a case report |
| title_fullStr | The underlying mechanism of Guillain-Barré syndrome in a young patient suffered from Japanese encephalitis virus infection: a case report |
| title_full_unstemmed | The underlying mechanism of Guillain-Barré syndrome in a young patient suffered from Japanese encephalitis virus infection: a case report |
| title_short | The underlying mechanism of Guillain-Barré syndrome in a young patient suffered from Japanese encephalitis virus infection: a case report |
| title_sort | underlying mechanism of guillain barre syndrome in a young patient suffered from japanese encephalitis virus infection a case report |
| topic | Guillain-Barré syndrome Japanese encephalitis virus Vaccination Pathogenesis |
| url | https://doi.org/10.1186/s12985-022-01870-7 |
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