Symptom Persistence and Memory Performance in Posttraumatic Stress Disorder: A Gene X Environment Pilot Study
The FKBP5 gene, a glucocorticoid receptor (GR)-regulating co-chaperone of stress proteins, is of special interest because of its role in hypothalamic-pituitary-adrenal (HPA)-axis regulation. However, studies finding a genetic relationship between posttraumatic stress disorder (PTSD) and the FKBP5 ge...
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| Format: | Article |
| Language: | English |
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MDPI AG
2012-06-01
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| Series: | Behavioral Sciences |
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| Online Access: | http://www.mdpi.com/2076-328X/2/2/103 |
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| author | Annie-Claude David Geeta A. Thakur Vivian Akerib Jorge Armony Isabelle Rouleau Alain Brunet |
| author_facet | Annie-Claude David Geeta A. Thakur Vivian Akerib Jorge Armony Isabelle Rouleau Alain Brunet |
| author_sort | Annie-Claude David |
| collection | DOAJ |
| description | The FKBP5 gene, a glucocorticoid receptor (GR)-regulating co-chaperone of stress proteins, is of special interest because of its role in hypothalamic-pituitary-adrenal (HPA)-axis regulation. However, studies finding a genetic relationship between posttraumatic stress disorder (PTSD) and the FKBP5 gene have failed to distinguish between the development and persistence of PTSD, thereby limiting the prognostic usefulness of such a finding. The present study sought to longitudinally explore this question by examining the association between four single-nucleotide polymorphisms (SNPs) in the FKBP5 gene (rs3800373, rs9470080, rs1360780, and rs9296158), the persistence of PTSD (severity and diagnostic status), and memory performance among twenty-two treatment-seekers diagnosed with acute PTSD. Results showed that the four SNPs significantly interacted with improvement in PTSD symptoms as well as PTSD diagnostic status. Individuals homozygous for the dominant allele and having experienced higher levels of peritraumatic responses subsequently showed more memory dysfunction. The results of this study suggest that SNPs in the FKBP5 gene are associated with symptom persistence and memory dysfunction in acute PTSD. |
| first_indexed | 2024-12-11T16:27:04Z |
| format | Article |
| id | doaj.art-ad2339f5626544fba85abf85f6cf4f24 |
| institution | Directory Open Access Journal |
| issn | 2076-328X |
| language | English |
| last_indexed | 2024-12-11T16:27:04Z |
| publishDate | 2012-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Behavioral Sciences |
| spelling | doaj.art-ad2339f5626544fba85abf85f6cf4f242022-12-22T00:58:41ZengMDPI AGBehavioral Sciences2076-328X2012-06-012210311410.3390/bs2020103Symptom Persistence and Memory Performance in Posttraumatic Stress Disorder: A Gene X Environment Pilot StudyAnnie-Claude DavidGeeta A. ThakurVivian AkeribJorge ArmonyIsabelle RouleauAlain BrunetThe FKBP5 gene, a glucocorticoid receptor (GR)-regulating co-chaperone of stress proteins, is of special interest because of its role in hypothalamic-pituitary-adrenal (HPA)-axis regulation. However, studies finding a genetic relationship between posttraumatic stress disorder (PTSD) and the FKBP5 gene have failed to distinguish between the development and persistence of PTSD, thereby limiting the prognostic usefulness of such a finding. The present study sought to longitudinally explore this question by examining the association between four single-nucleotide polymorphisms (SNPs) in the FKBP5 gene (rs3800373, rs9470080, rs1360780, and rs9296158), the persistence of PTSD (severity and diagnostic status), and memory performance among twenty-two treatment-seekers diagnosed with acute PTSD. Results showed that the four SNPs significantly interacted with improvement in PTSD symptoms as well as PTSD diagnostic status. Individuals homozygous for the dominant allele and having experienced higher levels of peritraumatic responses subsequently showed more memory dysfunction. The results of this study suggest that SNPs in the FKBP5 gene are associated with symptom persistence and memory dysfunction in acute PTSD.http://www.mdpi.com/2076-328X/2/2/103FKBP5HPA-axisglucocorticoid receptorremissionCanadians |
| spellingShingle | Annie-Claude David Geeta A. Thakur Vivian Akerib Jorge Armony Isabelle Rouleau Alain Brunet Symptom Persistence and Memory Performance in Posttraumatic Stress Disorder: A Gene X Environment Pilot Study Behavioral Sciences FKBP5 HPA-axis glucocorticoid receptor remission Canadians |
| title | Symptom Persistence and Memory Performance in Posttraumatic Stress Disorder: A Gene X Environment Pilot Study |
| title_full | Symptom Persistence and Memory Performance in Posttraumatic Stress Disorder: A Gene X Environment Pilot Study |
| title_fullStr | Symptom Persistence and Memory Performance in Posttraumatic Stress Disorder: A Gene X Environment Pilot Study |
| title_full_unstemmed | Symptom Persistence and Memory Performance in Posttraumatic Stress Disorder: A Gene X Environment Pilot Study |
| title_short | Symptom Persistence and Memory Performance in Posttraumatic Stress Disorder: A Gene X Environment Pilot Study |
| title_sort | symptom persistence and memory performance in posttraumatic stress disorder a gene x environment pilot study |
| topic | FKBP5 HPA-axis glucocorticoid receptor remission Canadians |
| url | http://www.mdpi.com/2076-328X/2/2/103 |
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