Neuroendocrine Role for VGF
The vgf gene (non-acronymic) is highly conserved and was identified on the basis of its rapid induction in vitro by nerve growth factor, although can also be induced by brain derived neurotrophic factor, and glial derived growth factor. The VGF gene gives rise to a 68kDa precursor polypeptide which...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-02-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fendo.2015.00003/full |
| _version_ | 1818620892638347264 |
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| author | Jo Edward Lewis John M Brameld Preeti H Jethwa |
| author_facet | Jo Edward Lewis John M Brameld Preeti H Jethwa |
| author_sort | Jo Edward Lewis |
| collection | DOAJ |
| description | The vgf gene (non-acronymic) is highly conserved and was identified on the basis of its rapid induction in vitro by nerve growth factor, although can also be induced by brain derived neurotrophic factor, and glial derived growth factor. The VGF gene gives rise to a 68kDa precursor polypeptide which is induced robustly, relatively selectively and is synthesized exclusively in neuronal and neuroendocrine cells. Post-translational processing by neuroendocrine specific pro-hormone convertases in these cells results in the production of a number of smaller peptides. The VGF gene and peptides are widely expressed throughout the brain, particularly the hypothalamus and hippocampus, and in peripheral tissues including the pituitary gland, the adrenal glands and the pancreas, and in the gastrointestinal tract in both the myenteric plexus and in endocrine cells. VGF peptides have been associated with a number of neuroendocrine roles and in this mini-review we aim to describe these roles to highlight the importance of VGF as therapeutic target for a number of disorders, particularly those associated with energy metabolism, pain, reproduction and cognition. |
| first_indexed | 2024-12-16T18:00:36Z |
| format | Article |
| id | doaj.art-ad23be878de44f079575197be6cc9677 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-16T18:00:36Z |
| publishDate | 2015-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-ad23be878de44f079575197be6cc96772022-12-21T22:22:03ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922015-02-01610.3389/fendo.2015.00003124271Neuroendocrine Role for VGFJo Edward Lewis0John M Brameld1Preeti H Jethwa2University of NottinghamUniversity of NottinghamUniversity of NottinghamThe vgf gene (non-acronymic) is highly conserved and was identified on the basis of its rapid induction in vitro by nerve growth factor, although can also be induced by brain derived neurotrophic factor, and glial derived growth factor. The VGF gene gives rise to a 68kDa precursor polypeptide which is induced robustly, relatively selectively and is synthesized exclusively in neuronal and neuroendocrine cells. Post-translational processing by neuroendocrine specific pro-hormone convertases in these cells results in the production of a number of smaller peptides. The VGF gene and peptides are widely expressed throughout the brain, particularly the hypothalamus and hippocampus, and in peripheral tissues including the pituitary gland, the adrenal glands and the pancreas, and in the gastrointestinal tract in both the myenteric plexus and in endocrine cells. VGF peptides have been associated with a number of neuroendocrine roles and in this mini-review we aim to describe these roles to highlight the importance of VGF as therapeutic target for a number of disorders, particularly those associated with energy metabolism, pain, reproduction and cognition.http://journal.frontiersin.org/Journal/10.3389/fendo.2015.00003/fullCognitionDepressionPainReproductionenergy homeostasisVGF |
| spellingShingle | Jo Edward Lewis John M Brameld Preeti H Jethwa Neuroendocrine Role for VGF Frontiers in Endocrinology Cognition Depression Pain Reproduction energy homeostasis VGF |
| title | Neuroendocrine Role for VGF |
| title_full | Neuroendocrine Role for VGF |
| title_fullStr | Neuroendocrine Role for VGF |
| title_full_unstemmed | Neuroendocrine Role for VGF |
| title_short | Neuroendocrine Role for VGF |
| title_sort | neuroendocrine role for vgf |
| topic | Cognition Depression Pain Reproduction energy homeostasis VGF |
| url | http://journal.frontiersin.org/Journal/10.3389/fendo.2015.00003/full |
| work_keys_str_mv | AT joedwardlewis neuroendocrineroleforvgf AT johnmbrameld neuroendocrineroleforvgf AT preetihjethwa neuroendocrineroleforvgf |