Fatty acids in cancer: Metabolic functions and potential treatment
Abstract Lipid metabolic reprogramming is one of the important metabolic characteristics of cancer cells. As major components of lipids, fatty acids provide energy and material basis for cancer cell survival. Abnormal fatty acid metabolism has been found in many cancers. Fatty acid uptake, transport...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-03-01
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| Series: | MedComm – Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/mog2.25 |
| _version_ | 1797829225277816832 |
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| author | Ao Du Zhen Wang Tengda Huang Shuai Xue Chuang Jiang Guoteng Qiu Kefei Yuan |
| author_facet | Ao Du Zhen Wang Tengda Huang Shuai Xue Chuang Jiang Guoteng Qiu Kefei Yuan |
| author_sort | Ao Du |
| collection | DOAJ |
| description | Abstract Lipid metabolic reprogramming is one of the important metabolic characteristics of cancer cells. As major components of lipids, fatty acids provide energy and material basis for cancer cell survival. Abnormal fatty acid metabolism has been found in many cancers. Fatty acid uptake, transport, and synthesis are closely related to the pathogenesis of cancer. Meanwhile, fatty acid changes in the membrane structure of cancer cells and signal transduction mediated by signaling lipids are also helping cancer cells survive in the changing microenvironment. Some of these enzymes and metabolites involved in fatty acid metabolism are emerging as unique cancer biomarkers. Multiple studies have shown that disordered fatty acids can regulate tumor cell proliferation, metastasis, and drug resistance. Therefore, targeting fatty acid metabolism has become a promising treatment strategy. Here, we mainly present metabolic alterations of fatty acids, the basic components of lipids, in cancer. We discuss the cancer treatment based on fatty acid and fatty acid metabolism. These may provide a basis for a better understanding of lipid metabolic reprogramming in cancer, and also provide new ideas for cancer biomarker search, drug development, and combination therapy. |
| first_indexed | 2024-04-09T13:16:58Z |
| format | Article |
| id | doaj.art-ad24a5b14d8a4f5c846841265182c81a |
| institution | Directory Open Access Journal |
| issn | 2769-6448 |
| language | English |
| last_indexed | 2024-04-09T13:16:58Z |
| publishDate | 2023-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | MedComm – Oncology |
| spelling | doaj.art-ad24a5b14d8a4f5c846841265182c81a2023-05-11T17:25:28ZengWileyMedComm – Oncology2769-64482023-03-0121n/an/a10.1002/mog2.25Fatty acids in cancer: Metabolic functions and potential treatmentAo Du0Zhen Wang1Tengda Huang2Shuai Xue3Chuang Jiang4Guoteng Qiu5Kefei Yuan6Department of Liver Surgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital Sichuan University and Collaborative Innovation Center of Biotherapy Chengdu ChinaDepartment of Liver Surgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital Sichuan University and Collaborative Innovation Center of Biotherapy Chengdu ChinaDepartment of Liver Surgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital Sichuan University and Collaborative Innovation Center of Biotherapy Chengdu ChinaDepartment of Liver Surgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital Sichuan University and Collaborative Innovation Center of Biotherapy Chengdu ChinaDepartment of Liver Surgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital Sichuan University and Collaborative Innovation Center of Biotherapy Chengdu ChinaDepartment of Liver Surgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital Sichuan University and Collaborative Innovation Center of Biotherapy Chengdu ChinaDepartment of Liver Surgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital Sichuan University and Collaborative Innovation Center of Biotherapy Chengdu ChinaAbstract Lipid metabolic reprogramming is one of the important metabolic characteristics of cancer cells. As major components of lipids, fatty acids provide energy and material basis for cancer cell survival. Abnormal fatty acid metabolism has been found in many cancers. Fatty acid uptake, transport, and synthesis are closely related to the pathogenesis of cancer. Meanwhile, fatty acid changes in the membrane structure of cancer cells and signal transduction mediated by signaling lipids are also helping cancer cells survive in the changing microenvironment. Some of these enzymes and metabolites involved in fatty acid metabolism are emerging as unique cancer biomarkers. Multiple studies have shown that disordered fatty acids can regulate tumor cell proliferation, metastasis, and drug resistance. Therefore, targeting fatty acid metabolism has become a promising treatment strategy. Here, we mainly present metabolic alterations of fatty acids, the basic components of lipids, in cancer. We discuss the cancer treatment based on fatty acid and fatty acid metabolism. These may provide a basis for a better understanding of lipid metabolic reprogramming in cancer, and also provide new ideas for cancer biomarker search, drug development, and combination therapy.https://doi.org/10.1002/mog2.25cancerfatty acidsmembrane lipidsmetabolic enzymesmetabolitestreatment strategy |
| spellingShingle | Ao Du Zhen Wang Tengda Huang Shuai Xue Chuang Jiang Guoteng Qiu Kefei Yuan Fatty acids in cancer: Metabolic functions and potential treatment MedComm – Oncology cancer fatty acids membrane lipids metabolic enzymes metabolites treatment strategy |
| title | Fatty acids in cancer: Metabolic functions and potential treatment |
| title_full | Fatty acids in cancer: Metabolic functions and potential treatment |
| title_fullStr | Fatty acids in cancer: Metabolic functions and potential treatment |
| title_full_unstemmed | Fatty acids in cancer: Metabolic functions and potential treatment |
| title_short | Fatty acids in cancer: Metabolic functions and potential treatment |
| title_sort | fatty acids in cancer metabolic functions and potential treatment |
| topic | cancer fatty acids membrane lipids metabolic enzymes metabolites treatment strategy |
| url | https://doi.org/10.1002/mog2.25 |
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