Disseminated Enterovirus Infection in a Patient Affected by Follicular Lymphoma Treated with Obinutuzumab: A Case Report and a Narrative Review of the Literature
<i>Background and Objectives</i>: the principal purpose of this literature review is to cluster adults with hematological malignancies after treatment or on maintenance with obinutuzumab who experienced disseminated EV infection to understand clinical characteristics and outcome of this...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/60/3/495 |
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| author | Tommaso Lupia Silvia Corcione Elena Staffilano Roberta Bosio Antonio Curtoni Alessandro Busca Francesco Giuseppe De Rosa |
| author_facet | Tommaso Lupia Silvia Corcione Elena Staffilano Roberta Bosio Antonio Curtoni Alessandro Busca Francesco Giuseppe De Rosa |
| author_sort | Tommaso Lupia |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: the principal purpose of this literature review is to cluster adults with hematological malignancies after treatment or on maintenance with obinutuzumab who experienced disseminated EV infection to understand clinical characteristics and outcome of this rare condition in these patients. We report the first clinical case of a male affected by follicular lymphoma treated with immune-chemotherapy including obinutuzumab who was affected by disseminated EV infection with cardiovascular involvement. <i>Materials and Methods</i>: this narrative review summarizes all the research about disseminated EV infection in immunosuppressed adult patients treated with obinutuzumab from January 2000 to January 2024 using the Scale for the Assessment of Narrative Review Articles (SANRA) flow-chart. We performed a descriptive statistic using the standard statistical measures for quantitative data. <i>Results</i>: we included six studies, five case reports, and one case report with literature analysis. We collected a total of seven patients, all female, with disseminated EV infection. The most common signs and clinical presentations of EV infection were fever and encephalitis symptoms (N = 6, 85.7%), followed by hepatitis/acute liver failure (N = 5, 71.4%). <i>Conclusions</i>: onco-hematological patients who receive immune-chemotherapy with a combination of treatments which depress adaptative immunity, which includes the antiCD20 obinutuzumab, could be at higher risk of disseminated EV infection, including CNS and cardiac involvement. |
| first_indexed | 2024-04-24T18:01:53Z |
| format | Article |
| id | doaj.art-ad264a018df447a4a6a4825d3ec01094 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-04-24T18:01:53Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-ad264a018df447a4a6a4825d3ec010942024-03-27T13:53:50ZengMDPI AGMedicina1010-660X1648-91442024-03-0160349510.3390/medicina60030495Disseminated Enterovirus Infection in a Patient Affected by Follicular Lymphoma Treated with Obinutuzumab: A Case Report and a Narrative Review of the LiteratureTommaso Lupia0Silvia Corcione1Elena Staffilano2Roberta Bosio3Antonio Curtoni4Alessandro Busca5Francesco Giuseppe De Rosa6Unit of Infectious Diseases, AOU City of Health and Sciences, 10100 Turin, ItalyUnit of Infectious Diseases, AOU City of Health and Sciences, 10100 Turin, ItalyDepartment of Medical Sciences, Infectious Diseases, University of Turin, 10126 Turin, ItalyDepartment of Medical Sciences, Infectious Diseases, University of Turin, 10126 Turin, ItalyMicrobiology and Virology Unit, AOU City of Health and Sciences, 10100 Turin, ItalyDepartment of Oncology, Stem Cell Transplant Center, Città Della Salute e Della Scienza Hospital, 10100 Turin, ItalyUnit of Infectious Diseases, AOU City of Health and Sciences, 10100 Turin, Italy<i>Background and Objectives</i>: the principal purpose of this literature review is to cluster adults with hematological malignancies after treatment or on maintenance with obinutuzumab who experienced disseminated EV infection to understand clinical characteristics and outcome of this rare condition in these patients. We report the first clinical case of a male affected by follicular lymphoma treated with immune-chemotherapy including obinutuzumab who was affected by disseminated EV infection with cardiovascular involvement. <i>Materials and Methods</i>: this narrative review summarizes all the research about disseminated EV infection in immunosuppressed adult patients treated with obinutuzumab from January 2000 to January 2024 using the Scale for the Assessment of Narrative Review Articles (SANRA) flow-chart. We performed a descriptive statistic using the standard statistical measures for quantitative data. <i>Results</i>: we included six studies, five case reports, and one case report with literature analysis. We collected a total of seven patients, all female, with disseminated EV infection. The most common signs and clinical presentations of EV infection were fever and encephalitis symptoms (N = 6, 85.7%), followed by hepatitis/acute liver failure (N = 5, 71.4%). <i>Conclusions</i>: onco-hematological patients who receive immune-chemotherapy with a combination of treatments which depress adaptative immunity, which includes the antiCD20 obinutuzumab, could be at higher risk of disseminated EV infection, including CNS and cardiac involvement.https://www.mdpi.com/1648-9144/60/3/495enterovirusobinutuzumablymphomaencephalitishematological malignancy |
| spellingShingle | Tommaso Lupia Silvia Corcione Elena Staffilano Roberta Bosio Antonio Curtoni Alessandro Busca Francesco Giuseppe De Rosa Disseminated Enterovirus Infection in a Patient Affected by Follicular Lymphoma Treated with Obinutuzumab: A Case Report and a Narrative Review of the Literature Medicina enterovirus obinutuzumab lymphoma encephalitis hematological malignancy |
| title | Disseminated Enterovirus Infection in a Patient Affected by Follicular Lymphoma Treated with Obinutuzumab: A Case Report and a Narrative Review of the Literature |
| title_full | Disseminated Enterovirus Infection in a Patient Affected by Follicular Lymphoma Treated with Obinutuzumab: A Case Report and a Narrative Review of the Literature |
| title_fullStr | Disseminated Enterovirus Infection in a Patient Affected by Follicular Lymphoma Treated with Obinutuzumab: A Case Report and a Narrative Review of the Literature |
| title_full_unstemmed | Disseminated Enterovirus Infection in a Patient Affected by Follicular Lymphoma Treated with Obinutuzumab: A Case Report and a Narrative Review of the Literature |
| title_short | Disseminated Enterovirus Infection in a Patient Affected by Follicular Lymphoma Treated with Obinutuzumab: A Case Report and a Narrative Review of the Literature |
| title_sort | disseminated enterovirus infection in a patient affected by follicular lymphoma treated with obinutuzumab a case report and a narrative review of the literature |
| topic | enterovirus obinutuzumab lymphoma encephalitis hematological malignancy |
| url | https://www.mdpi.com/1648-9144/60/3/495 |
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