Metabolite Variations in the Hippocampus and Corpus Callosum of Patients with Mild Cognitive Impairment Using Magnetic Resonance Spectroscopy with Three-Dimensional Chemical Shift Images
This study compared the metabolites in the brain regions of hippocampus and corpus callosum between patients with mild cognitive impairment (MCI) and healthy controls using no-radiation and high-sensitivity magnetic resonance spectroscopy (MRS) with three-dimensional chemical shift images (3D-CSI)....
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MDPI AG
2023-08-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/13/9/1244 |
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| author | Yen-Lon Kau I-Hung Lin Chi-Long Juang Chao-Kai Chang Wen-Hsiang Ho Hsiao-Chuan Wen |
| author_facet | Yen-Lon Kau I-Hung Lin Chi-Long Juang Chao-Kai Chang Wen-Hsiang Ho Hsiao-Chuan Wen |
| author_sort | Yen-Lon Kau |
| collection | DOAJ |
| description | This study compared the metabolites in the brain regions of hippocampus and corpus callosum between patients with mild cognitive impairment (MCI) and healthy controls using no-radiation and high-sensitivity magnetic resonance spectroscopy (MRS) with three-dimensional chemical shift images (3D-CSI). Twenty volunteers (seven patients with MCI and 13 healthy controls) aged 50–71 years were recruited for this prospective study. MRS with 3D-CSI images of a variety of metabolites was collected from the hippocampus and corpus callosum. Sex and weight showed no significant differences between the two groups. The metabolite levels in the hippocampus and corpus callosum of the MCI group were generally lower than in those of the healthy group, especially for creatine (<i>p</i> < 0.001 in the hippocampus and <i>p</i> = 0.020 in the corpus callosum) and N-acetyl aspartate/creatine (<i>p</i> < 0.001 in the hippocampus and <i>p</i> = 0.020 in the corpus callosum); however, choline/creatine showed a significant difference (<i>p</i> < 0.001) only in the hippocampus, and myo-inositol/creatine showed a significant difference (<i>p</i> < 0.001) only in the corpus callosum. Our study demonstrated that MRS with 3D-CSI can be used to measure these metabolite levels to determine the differences between patients with MCI and healthy individuals. This would aid early diagnosis of MCI in clinical practice, and patients could receive prompt intervention to improve their quality of life. |
| first_indexed | 2024-03-10T22:59:37Z |
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| id | doaj.art-ad28ca077bc04f19991ac821d1d42f1c |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T22:59:37Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-ad28ca077bc04f19991ac821d1d42f1c2023-11-19T09:48:16ZengMDPI AGBrain Sciences2076-34252023-08-01139124410.3390/brainsci13091244Metabolite Variations in the Hippocampus and Corpus Callosum of Patients with Mild Cognitive Impairment Using Magnetic Resonance Spectroscopy with Three-Dimensional Chemical Shift ImagesYen-Lon Kau0I-Hung Lin1Chi-Long Juang2Chao-Kai Chang3Wen-Hsiang Ho4Hsiao-Chuan Wen5Department of Medical Imaging, Camillian St. Mary’s Hospital, Luodong, Yilan 265502, TaiwanNobel Eye Institute, Taipei 100008, TaiwanDepartment of Medical Imaging and Radiological Sciences, Yuanpei University, Hsinchu 30015, TaiwanNobel Eye Institute, Taipei 100008, TaiwanDepartment of Medical Imaging, Camillian St. Mary’s Hospital, Luodong, Yilan 265502, TaiwanDepartment of Pet Healthcare, Yuanpei University, Hsinchu 300, TaiwanThis study compared the metabolites in the brain regions of hippocampus and corpus callosum between patients with mild cognitive impairment (MCI) and healthy controls using no-radiation and high-sensitivity magnetic resonance spectroscopy (MRS) with three-dimensional chemical shift images (3D-CSI). Twenty volunteers (seven patients with MCI and 13 healthy controls) aged 50–71 years were recruited for this prospective study. MRS with 3D-CSI images of a variety of metabolites was collected from the hippocampus and corpus callosum. Sex and weight showed no significant differences between the two groups. The metabolite levels in the hippocampus and corpus callosum of the MCI group were generally lower than in those of the healthy group, especially for creatine (<i>p</i> < 0.001 in the hippocampus and <i>p</i> = 0.020 in the corpus callosum) and N-acetyl aspartate/creatine (<i>p</i> < 0.001 in the hippocampus and <i>p</i> = 0.020 in the corpus callosum); however, choline/creatine showed a significant difference (<i>p</i> < 0.001) only in the hippocampus, and myo-inositol/creatine showed a significant difference (<i>p</i> < 0.001) only in the corpus callosum. Our study demonstrated that MRS with 3D-CSI can be used to measure these metabolite levels to determine the differences between patients with MCI and healthy individuals. This would aid early diagnosis of MCI in clinical practice, and patients could receive prompt intervention to improve their quality of life.https://www.mdpi.com/2076-3425/13/9/1244mild cognitive impairmentmagnetic resonance imagingmagnetic resonance spectroscopyhippocampal gyruscorpus callosum |
| spellingShingle | Yen-Lon Kau I-Hung Lin Chi-Long Juang Chao-Kai Chang Wen-Hsiang Ho Hsiao-Chuan Wen Metabolite Variations in the Hippocampus and Corpus Callosum of Patients with Mild Cognitive Impairment Using Magnetic Resonance Spectroscopy with Three-Dimensional Chemical Shift Images Brain Sciences mild cognitive impairment magnetic resonance imaging magnetic resonance spectroscopy hippocampal gyrus corpus callosum |
| title | Metabolite Variations in the Hippocampus and Corpus Callosum of Patients with Mild Cognitive Impairment Using Magnetic Resonance Spectroscopy with Three-Dimensional Chemical Shift Images |
| title_full | Metabolite Variations in the Hippocampus and Corpus Callosum of Patients with Mild Cognitive Impairment Using Magnetic Resonance Spectroscopy with Three-Dimensional Chemical Shift Images |
| title_fullStr | Metabolite Variations in the Hippocampus and Corpus Callosum of Patients with Mild Cognitive Impairment Using Magnetic Resonance Spectroscopy with Three-Dimensional Chemical Shift Images |
| title_full_unstemmed | Metabolite Variations in the Hippocampus and Corpus Callosum of Patients with Mild Cognitive Impairment Using Magnetic Resonance Spectroscopy with Three-Dimensional Chemical Shift Images |
| title_short | Metabolite Variations in the Hippocampus and Corpus Callosum of Patients with Mild Cognitive Impairment Using Magnetic Resonance Spectroscopy with Three-Dimensional Chemical Shift Images |
| title_sort | metabolite variations in the hippocampus and corpus callosum of patients with mild cognitive impairment using magnetic resonance spectroscopy with three dimensional chemical shift images |
| topic | mild cognitive impairment magnetic resonance imaging magnetic resonance spectroscopy hippocampal gyrus corpus callosum |
| url | https://www.mdpi.com/2076-3425/13/9/1244 |
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