Synthesis of Oleanolic Acid-Dithiocarbamate Conjugates and Evaluation of Their Broad-Spectrum Antitumor Activities

Synthesis of Oleanolic Acid-Dithiocarbamate Conjugates and Evaluation of Their Broad-Spectrum Antitumor Activities

Efficient and mild synthetic routes for bioactive natural product derivatives are of current interest for drug discovery. Herein, on the basis of the pharmacophore hybrid strategy, we report a two-step protocol to obtain a series of structurally novel oleanolic acid (OA)-dithiocarbamate conjugates i...

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Bibliographic Details
Main Authors: Liyao Tang, Yan Zhang, Jinrun Xu, Qingfan Yang, Fukuan Du, Xu Wu, Mingxing Li, Jing Shen, Shuai Deng, Yueshui Zhao, Zhangang Xiao, Yu Chen
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Molecules
Subjects:
structural modification
oleanolic acid
natural product derivative
dithiocarbamate
hybrid strategy
antitumor activity
Online Access:https://www.mdpi.com/1420-3049/28/3/1414

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