Allergic Asthma-Induced Cognitive Impairment is Alleviated by Dexamethasone
Allergic asthma is a typical chronic inflammatory disease of respiratory tract. Clinical data shows that patients with allergic asthma have different degrees of cognitive dysfunction. The molecular mechanism underlying the pathogenesis of asthma-induced cognitive disorder is not yet well defined. De...
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2021.680815/full |
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| author | Mengli Ren Min Feng Zhimin Long Zhimin Long Jing Ma Jing Ma Xuehua Peng Guiqiong He Guiqiong He |
| author_facet | Mengli Ren Min Feng Zhimin Long Zhimin Long Jing Ma Jing Ma Xuehua Peng Guiqiong He Guiqiong He |
| author_sort | Mengli Ren |
| collection | DOAJ |
| description | Allergic asthma is a typical chronic inflammatory disease of respiratory tract. Clinical data shows that patients with allergic asthma have different degrees of cognitive dysfunction. The molecular mechanism underlying the pathogenesis of asthma-induced cognitive disorder is not yet well defined. Dexamethasone (DEX), one of the first-line drugs being widely used in the treatment of asthma, has not been reported to have an effect on cognitive dysfunction in mice model. To investigate the effect of asthma on cognitive impairment as well as the effect of DEX on asthma-caused morphological and behavioral changes, C57BL/6J mice received treatment with house dust mites (HDM) for 60 days to become allergic asthma model mice, and a group of HDM-treated asthma model mice were treated with DEX. HDM-treated asthma model mice exhibited increased airway hyperresponsiveness (AHR) and inflammatory infiltration in lung tissue. An elevated level of IL-4, IL-5, and TNF-α was detected in bronchoalveolar lavage fluid (BALF) by Luminex liquid suspension chip. Asthma model mice also presented memory deficits accompanied with morphological changes at the synaptic levels in the cortex and hippocampus. Meanwhile, vascular edema and increased expression of HIF-1α and HIF-2α were found in the brain of asthma model mice. Interestingly, DEX treatment could reverse the inflammatory changes in asthma model mice airway, rescue the cognitive impairment and improve the synaptic plasticity. Besides, DEX significantly decreased the expression of HIF-1α and HIF-2α in mice brain and lung. These processes may be used to decipher the complex interplay and pathological changes between asthma and cognition. This study provides laboratory evidence for the prevention and treatment of cognitive malfunction induced by asthma. |
| first_indexed | 2024-12-22T02:35:53Z |
| format | Article |
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| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-22T02:35:53Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-ad2b601ffaf94725b69b289d5091db732022-12-21T18:41:45ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-06-011210.3389/fphar.2021.680815680815Allergic Asthma-Induced Cognitive Impairment is Alleviated by DexamethasoneMengli Ren0Min Feng1Zhimin Long2Zhimin Long3Jing Ma4Jing Ma5Xuehua Peng6Guiqiong He7Guiqiong He8Institute of Neuroscience, Basic Medical College, Chongqing Medical University, Chongqing, ChinaInstitute of Neuroscience, Basic Medical College, Chongqing Medical University, Chongqing, ChinaInstitute of Neuroscience, Basic Medical College, Chongqing Medical University, Chongqing, ChinaDepartment of Anatomy, Basic Medical College, Chongqing Medical University, Chongqing, ChinaInstitute of Neuroscience, Basic Medical College, Chongqing Medical University, Chongqing, ChinaDepartment of Anatomy, Basic Medical College, Chongqing Medical University, Chongqing, ChinaWuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Neuroscience, Basic Medical College, Chongqing Medical University, Chongqing, ChinaDepartment of Anatomy, Basic Medical College, Chongqing Medical University, Chongqing, ChinaAllergic asthma is a typical chronic inflammatory disease of respiratory tract. Clinical data shows that patients with allergic asthma have different degrees of cognitive dysfunction. The molecular mechanism underlying the pathogenesis of asthma-induced cognitive disorder is not yet well defined. Dexamethasone (DEX), one of the first-line drugs being widely used in the treatment of asthma, has not been reported to have an effect on cognitive dysfunction in mice model. To investigate the effect of asthma on cognitive impairment as well as the effect of DEX on asthma-caused morphological and behavioral changes, C57BL/6J mice received treatment with house dust mites (HDM) for 60 days to become allergic asthma model mice, and a group of HDM-treated asthma model mice were treated with DEX. HDM-treated asthma model mice exhibited increased airway hyperresponsiveness (AHR) and inflammatory infiltration in lung tissue. An elevated level of IL-4, IL-5, and TNF-α was detected in bronchoalveolar lavage fluid (BALF) by Luminex liquid suspension chip. Asthma model mice also presented memory deficits accompanied with morphological changes at the synaptic levels in the cortex and hippocampus. Meanwhile, vascular edema and increased expression of HIF-1α and HIF-2α were found in the brain of asthma model mice. Interestingly, DEX treatment could reverse the inflammatory changes in asthma model mice airway, rescue the cognitive impairment and improve the synaptic plasticity. Besides, DEX significantly decreased the expression of HIF-1α and HIF-2α in mice brain and lung. These processes may be used to decipher the complex interplay and pathological changes between asthma and cognition. This study provides laboratory evidence for the prevention and treatment of cognitive malfunction induced by asthma.https://www.frontiersin.org/articles/10.3389/fphar.2021.680815/fullallergic asthmacognitive functiondexamethasoneoxygen deficithouse dust mites |
| spellingShingle | Mengli Ren Min Feng Zhimin Long Zhimin Long Jing Ma Jing Ma Xuehua Peng Guiqiong He Guiqiong He Allergic Asthma-Induced Cognitive Impairment is Alleviated by Dexamethasone Frontiers in Pharmacology allergic asthma cognitive function dexamethasone oxygen deficit house dust mites |
| title | Allergic Asthma-Induced Cognitive Impairment is Alleviated by Dexamethasone |
| title_full | Allergic Asthma-Induced Cognitive Impairment is Alleviated by Dexamethasone |
| title_fullStr | Allergic Asthma-Induced Cognitive Impairment is Alleviated by Dexamethasone |
| title_full_unstemmed | Allergic Asthma-Induced Cognitive Impairment is Alleviated by Dexamethasone |
| title_short | Allergic Asthma-Induced Cognitive Impairment is Alleviated by Dexamethasone |
| title_sort | allergic asthma induced cognitive impairment is alleviated by dexamethasone |
| topic | allergic asthma cognitive function dexamethasone oxygen deficit house dust mites |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2021.680815/full |
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