The Role of the Body Clock in Asthma and COPD: Implication for Treatment
Abstract Asthma exhibits a marked time of day variation in symptoms, airway physiology, and airway inflammation. This is also seen in chronic obstructive pulmonary disease (COPD), but to a lesser extent. Our understanding of how physiological daily rhythms are regulated by the circadian clock is inc...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2018-06-01
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| Series: | Pulmonary Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s41030-018-0058-6 |
| _version_ | 1827291405410631680 |
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| author | Karolina Krakowiak Hannah J. Durrington |
| author_facet | Karolina Krakowiak Hannah J. Durrington |
| author_sort | Karolina Krakowiak |
| collection | DOAJ |
| description | Abstract Asthma exhibits a marked time of day variation in symptoms, airway physiology, and airway inflammation. This is also seen in chronic obstructive pulmonary disease (COPD), but to a lesser extent. Our understanding of how physiological daily rhythms are regulated by the circadian clock is increasing, and there is growing evidence that the molecular clock is important in the pathogenesis of these two airway diseases. If time of day is important, then it follows that treatment of asthma and COPD should also be tailored to the most efficacious time of the day, a concept known as ‘chronotherapy’. There have been a number of studies to determine the optimal time of day at which to take medications for asthma and COPD. Some of these agents are already used ‘chronotherapeutically’ in practice (often at night-time). However, several studies investigating systemic and inhaled corticosteroids have consistently shown that the best time of day to take these medications for treating asthma is in the afternoon or early evening and not in the morning, when these medications are often prescribed. Future, large, randomized, placebo-controlled studies of systemic and inhaled corticosteroids in asthma and COPD are needed to inform clinical practice. Digital Features This article is published with a graphical abstract to facilitate understanding of the article. To view digital features for this article go to the Supplementary Information of the article. |
| first_indexed | 2024-04-24T12:37:34Z |
| format | Article |
| id | doaj.art-ad2c6b6d89dd4f159d3ff6cc223da3ee |
| institution | Directory Open Access Journal |
| issn | 2364-1754 2364-1746 |
| language | English |
| last_indexed | 2024-04-24T12:37:34Z |
| publishDate | 2018-06-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Pulmonary Therapy |
| spelling | doaj.art-ad2c6b6d89dd4f159d3ff6cc223da3ee2024-04-07T11:26:25ZengAdis, Springer HealthcarePulmonary Therapy2364-17542364-17462018-06-0141294310.1007/s41030-018-0058-6The Role of the Body Clock in Asthma and COPD: Implication for TreatmentKarolina Krakowiak0Hannah J. Durrington1Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of ManchesterDivision of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of ManchesterAbstract Asthma exhibits a marked time of day variation in symptoms, airway physiology, and airway inflammation. This is also seen in chronic obstructive pulmonary disease (COPD), but to a lesser extent. Our understanding of how physiological daily rhythms are regulated by the circadian clock is increasing, and there is growing evidence that the molecular clock is important in the pathogenesis of these two airway diseases. If time of day is important, then it follows that treatment of asthma and COPD should also be tailored to the most efficacious time of the day, a concept known as ‘chronotherapy’. There have been a number of studies to determine the optimal time of day at which to take medications for asthma and COPD. Some of these agents are already used ‘chronotherapeutically’ in practice (often at night-time). However, several studies investigating systemic and inhaled corticosteroids have consistently shown that the best time of day to take these medications for treating asthma is in the afternoon or early evening and not in the morning, when these medications are often prescribed. Future, large, randomized, placebo-controlled studies of systemic and inhaled corticosteroids in asthma and COPD are needed to inform clinical practice. Digital Features This article is published with a graphical abstract to facilitate understanding of the article. To view digital features for this article go to the Supplementary Information of the article.https://doi.org/10.1007/s41030-018-0058-6AsthmaBMAL-1ChronotherapyCircadianClockCOPD |
| spellingShingle | Karolina Krakowiak Hannah J. Durrington The Role of the Body Clock in Asthma and COPD: Implication for Treatment Pulmonary Therapy Asthma BMAL-1 Chronotherapy Circadian Clock COPD |
| title | The Role of the Body Clock in Asthma and COPD: Implication for Treatment |
| title_full | The Role of the Body Clock in Asthma and COPD: Implication for Treatment |
| title_fullStr | The Role of the Body Clock in Asthma and COPD: Implication for Treatment |
| title_full_unstemmed | The Role of the Body Clock in Asthma and COPD: Implication for Treatment |
| title_short | The Role of the Body Clock in Asthma and COPD: Implication for Treatment |
| title_sort | role of the body clock in asthma and copd implication for treatment |
| topic | Asthma BMAL-1 Chronotherapy Circadian Clock COPD |
| url | https://doi.org/10.1007/s41030-018-0058-6 |
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