The Unfolded Protein Response in Immune Cells as an Emerging Regulator of Neuroinflammation
Immune surveillance is an essential process that safeguards the homeostasis of a healthy brain. Among the increasing diversity of immune cells present in the central nervous system (CNS), microglia have emerged as a prominent leukocyte subset with key roles in the support of brain function and in th...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2021.682633/full |
| _version_ | 1818641378701213696 |
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| author | Dominique Fernández Antonia Geisse Jose Ignacio Bernales Alonso Lira Fabiola Osorio |
| author_facet | Dominique Fernández Antonia Geisse Jose Ignacio Bernales Alonso Lira Fabiola Osorio |
| author_sort | Dominique Fernández |
| collection | DOAJ |
| description | Immune surveillance is an essential process that safeguards the homeostasis of a healthy brain. Among the increasing diversity of immune cells present in the central nervous system (CNS), microglia have emerged as a prominent leukocyte subset with key roles in the support of brain function and in the control of neuroinflammation. In fact, impaired microglial function is associated with the development of neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD). Interestingly, these pathologies are also typified by protein aggregation and proteostasis dysfunction at the level of the endoplasmic reticulum (ER). These processes trigger activation of the unfolded protein response (UPR), which is a conserved signaling network that maintains the fidelity of the cellular proteome. Remarkably, beyond its role in protein folding, the UPR has also emerged as a key regulator of the development and function of immune cells. However, despite this evidence, the contribution of the UPR to immune cell homeostasis, immune surveillance, and neuro-inflammatory processes remains largely unexplored. In this review, we discuss the potential contribution of the UPR in brain-associated immune cells in the context of neurodegenerative diseases. |
| first_indexed | 2024-12-16T23:26:13Z |
| format | Article |
| id | doaj.art-ad2e95684f46405c8578d9f44e8dcc08 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-16T23:26:13Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-ad2e95684f46405c8578d9f44e8dcc082022-12-21T22:11:59ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652021-06-011310.3389/fnagi.2021.682633682633The Unfolded Protein Response in Immune Cells as an Emerging Regulator of NeuroinflammationDominique FernándezAntonia GeisseJose Ignacio BernalesAlonso LiraFabiola OsorioImmune surveillance is an essential process that safeguards the homeostasis of a healthy brain. Among the increasing diversity of immune cells present in the central nervous system (CNS), microglia have emerged as a prominent leukocyte subset with key roles in the support of brain function and in the control of neuroinflammation. In fact, impaired microglial function is associated with the development of neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD). Interestingly, these pathologies are also typified by protein aggregation and proteostasis dysfunction at the level of the endoplasmic reticulum (ER). These processes trigger activation of the unfolded protein response (UPR), which is a conserved signaling network that maintains the fidelity of the cellular proteome. Remarkably, beyond its role in protein folding, the UPR has also emerged as a key regulator of the development and function of immune cells. However, despite this evidence, the contribution of the UPR to immune cell homeostasis, immune surveillance, and neuro-inflammatory processes remains largely unexplored. In this review, we discuss the potential contribution of the UPR in brain-associated immune cells in the context of neurodegenerative diseases.https://www.frontiersin.org/articles/10.3389/fnagi.2021.682633/fullUPRneurodegenerationmicrogliainflammationneuroinflammationprotein misfolding |
| spellingShingle | Dominique Fernández Antonia Geisse Jose Ignacio Bernales Alonso Lira Fabiola Osorio The Unfolded Protein Response in Immune Cells as an Emerging Regulator of Neuroinflammation Frontiers in Aging Neuroscience UPR neurodegeneration microglia inflammation neuroinflammation protein misfolding |
| title | The Unfolded Protein Response in Immune Cells as an Emerging Regulator of Neuroinflammation |
| title_full | The Unfolded Protein Response in Immune Cells as an Emerging Regulator of Neuroinflammation |
| title_fullStr | The Unfolded Protein Response in Immune Cells as an Emerging Regulator of Neuroinflammation |
| title_full_unstemmed | The Unfolded Protein Response in Immune Cells as an Emerging Regulator of Neuroinflammation |
| title_short | The Unfolded Protein Response in Immune Cells as an Emerging Regulator of Neuroinflammation |
| title_sort | unfolded protein response in immune cells as an emerging regulator of neuroinflammation |
| topic | UPR neurodegeneration microglia inflammation neuroinflammation protein misfolding |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2021.682633/full |
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