Nicotinic Acid Adenine Dinucleotide Phosphate Induces Intracellular Ca2+ Signalling and Stimulates Proliferation in Human Cardiac Mesenchymal Stromal Cells

Nicotinic Acid Adenine Dinucleotide Phosphate Induces Intracellular Ca2+ Signalling and Stimulates Proliferation in Human Cardiac Mesenchymal Stromal Cells

Nicotinic acid adenine dinucleotide phosphate (NAADP) is a newly discovered second messenger that gates two pore channels 1 (TPC1) and 2 (TPC2) to elicit endo-lysosomal (EL) Ca2+ release. NAADP-induced lysosomal Ca2+ release may be amplified by the endoplasmic reticulum (ER) through the Ca2+-induced...

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Bibliographic Details
Main Authors: Pawan Faris, Claudio Casali, Sharon Negri, Lara Iengo, Marco Biggiogera, Angela Serena Maione, Francesco Moccia
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
nicotinic acid adenine dinucleotide phosphate (NAADP)
two-pore channels (TPCs)
membrane contact sites
store operated Ca2+ entry
cardiac mesenchymal stem cells
proliferation
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.874043/full

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https://www.frontiersin.org/articles/10.3389/fcell.2022.874043/full

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