Relationship between diabetic retinopathy and cerebral perfusion in type 2 diabetes mellitus
Background: Compared to patients without diabetic retinopathy (DR), those with DR demonstrate better cognitive performance. It is therefore reasonable to hypothesize that retinal microcirculatory changes might be a marker of impaired cerebral microcirculation. Purpose: To examine the association...
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| Format: | Article |
| Language: | English |
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Ukrainian Society of Ophthalmologists
2018-02-01
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| Series: | Journal of Ophthalmology |
| Subjects: | |
| Online Access: | https://www.ozhurnal.com/en/archive/2018/1/9-fulltext |
| _version_ | 1797376584052637696 |
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| author | Zherdiova N.M. Medvedovska N.V. Makeev S.K. Mankovsky B.N. |
| author_facet | Zherdiova N.M. Medvedovska N.V. Makeev S.K. Mankovsky B.N. |
| author_sort | Zherdiova N.M. |
| collection | DOAJ |
| description | Background: Compared to patients without diabetic retinopathy (DR), those with DR demonstrate better cognitive performance. It is therefore reasonable to hypothesize that retinal microcirculatory changes might be a marker of impaired cerebral microcirculation.
Purpose: To examine the association between the presence of diabetic retinopathy and cerebral perfusion in patients with type 2 diabetes mellitus (T2DM).
Materials and Methods: Ninety-five T2DM patients aged 50-70 years were enrolled. They were divided into two groups, those with DR (DR group) and without DR (non-DR group). Regional cerebral blood flows (rCBF) were measured with 99mTc-HMPAO single-photon emission computed tomography (SPECT).
Results: Linear regression analysis revealed negative relationships between DR and cerebral perfusion impairments in right frontal lobe (B (95% CI) = 0.58 (-0.98/-0.18); P = 0.01), left frontal (B (95% CI) = -0.55 (-0.99/-0.12); P = 0.02) lobe, right parietal lobe (B (95% CI) = -0.68 (-1.19/-0.16); P = 0.01), left parietal lobe (B (95% CI) = -0.79 (-1.31/-0.27); P = 0.00); right occipital lobe (B (95% CI) = -0.61(-1.17/-0.06); P = 0.03), left occipital lobe (B (95% CI) = -0.81 (-1.35/-0.26); P = 0.00); right cerebral cortex (B (95% CI) = -0,58 (-0.98/-0.18); P = 0.01) and left cerebral cortex (B (95% CI) = -0.54 (-91/-0.17); P = 0.01).
Conclusions: The findings might indicate that, in diabetic patients, damage to retinal microvessels develops somewhat in parallel with that to the brain. |
| first_indexed | 2024-03-08T19:40:39Z |
| format | Article |
| id | doaj.art-ad2fee3638c549429a58ff5296464429 |
| institution | Directory Open Access Journal |
| issn | 2412-8740 |
| language | English |
| last_indexed | 2024-03-08T19:40:39Z |
| publishDate | 2018-02-01 |
| publisher | Ukrainian Society of Ophthalmologists |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj.art-ad2fee3638c549429a58ff52964644292023-12-25T09:17:12ZengUkrainian Society of OphthalmologistsJournal of Ophthalmology2412-87402018-02-011495310.31288/oftalmolzh201814953Relationship between diabetic retinopathy and cerebral perfusion in type 2 diabetes mellitusZherdiova N.M.0Medvedovska N.V.1Makeev S.K.2Mankovsky B.N.3Shupyk National Medical Academy of Postgraduate EducationShupyk National Medical Academy of Postgraduate EducationShupyk National Medical Academy of Postgraduate EducationShupyk National Medical Academy of Postgraduate EducationBackground: Compared to patients without diabetic retinopathy (DR), those with DR demonstrate better cognitive performance. It is therefore reasonable to hypothesize that retinal microcirculatory changes might be a marker of impaired cerebral microcirculation. Purpose: To examine the association between the presence of diabetic retinopathy and cerebral perfusion in patients with type 2 diabetes mellitus (T2DM). Materials and Methods: Ninety-five T2DM patients aged 50-70 years were enrolled. They were divided into two groups, those with DR (DR group) and without DR (non-DR group). Regional cerebral blood flows (rCBF) were measured with 99mTc-HMPAO single-photon emission computed tomography (SPECT). Results: Linear regression analysis revealed negative relationships between DR and cerebral perfusion impairments in right frontal lobe (B (95% CI) = 0.58 (-0.98/-0.18); P = 0.01), left frontal (B (95% CI) = -0.55 (-0.99/-0.12); P = 0.02) lobe, right parietal lobe (B (95% CI) = -0.68 (-1.19/-0.16); P = 0.01), left parietal lobe (B (95% CI) = -0.79 (-1.31/-0.27); P = 0.00); right occipital lobe (B (95% CI) = -0.61(-1.17/-0.06); P = 0.03), left occipital lobe (B (95% CI) = -0.81 (-1.35/-0.26); P = 0.00); right cerebral cortex (B (95% CI) = -0,58 (-0.98/-0.18); P = 0.01) and left cerebral cortex (B (95% CI) = -0.54 (-91/-0.17); P = 0.01). Conclusions: The findings might indicate that, in diabetic patients, damage to retinal microvessels develops somewhat in parallel with that to the brain.https://www.ozhurnal.com/en/archive/2018/1/9-fulltextdiabetic retinopathytype 2 diabetes mellituscerebral blood flow |
| spellingShingle | Zherdiova N.M. Medvedovska N.V. Makeev S.K. Mankovsky B.N. Relationship between diabetic retinopathy and cerebral perfusion in type 2 diabetes mellitus Journal of Ophthalmology diabetic retinopathy type 2 diabetes mellitus cerebral blood flow |
| title | Relationship between diabetic retinopathy and cerebral perfusion in type 2 diabetes mellitus |
| title_full | Relationship between diabetic retinopathy and cerebral perfusion in type 2 diabetes mellitus |
| title_fullStr | Relationship between diabetic retinopathy and cerebral perfusion in type 2 diabetes mellitus |
| title_full_unstemmed | Relationship between diabetic retinopathy and cerebral perfusion in type 2 diabetes mellitus |
| title_short | Relationship between diabetic retinopathy and cerebral perfusion in type 2 diabetes mellitus |
| title_sort | relationship between diabetic retinopathy and cerebral perfusion in type 2 diabetes mellitus |
| topic | diabetic retinopathy type 2 diabetes mellitus cerebral blood flow |
| url | https://www.ozhurnal.com/en/archive/2018/1/9-fulltext |
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