The incidence of cough induced by remifentanil during anesthetic induction was decreased by graded escalation of the remifentanil concentration
BackgroundIt is well known that opioids induce coughing. Many drugs such as lidocaine and ketamine are used to effectively prevent the coughing induced by opioids and this has been revealed to be effective. In this study, we evaluated the preventive effect of a graded escalation of the remifentanil...
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| Format: | Article |
| Language: | English |
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Korean Society of Anesthesiologists
2010-02-01
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| Series: | Korean Journal of Anesthesiology |
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| Online Access: | http://ekja.org/upload/pdf/kjae-58-117.pdf |
| _version_ | 1819211977719808000 |
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| author | Ji Hun Lim Sie Jeong Ryu Young Soo Lim |
| author_facet | Ji Hun Lim Sie Jeong Ryu Young Soo Lim |
| author_sort | Ji Hun Lim |
| collection | DOAJ |
| description | BackgroundIt is well known that opioids induce coughing. Many drugs such as lidocaine and ketamine are used to effectively prevent the coughing induced by opioids and this has been revealed to be effective. In this study, we evaluated the preventive effect of a graded escalation of the remifentanil concentration using a target controlled infusion pump and we compared this with the effect of lidocaine.MethodsOne hundred fifty ASA I and II patients who were scheduled for elective surgery were randomly divided into 3 groups. The patients were pretreated with 2% lidocaine 1 mg/kg (Group L) or saline (Group S) and remifentanil infusion (an effect site concentration of 4.0 ng/ml) was followed 1 minute later by using a target controlled infusion pump. Group R was pretreated with saline and this was followed by remifentanil infusion (effect site concentration of 2.0 ng/ml at first and then it was reset to 4.0 ng/ml). We evaluated the incidence, severity and onset time of cough after remifentanil infusion.ResultsThe incidence of coughing was significantly decreased in Group R (6 cases, 12%) and Group L (7 cases, 14%), as compared to that of Group S (17 cases, 34%) (P < 0.05), but there was no significant difference between Group R and Group L. The groups showed no significant difference in the severity and the onset time of coughing.ConclusionsThis study demonstrated that administering graded escalation of the remifentanil concentration suppresses remifentanil-induced coughing as effectively as lidocaine 1 mg/kg pretreatment. |
| first_indexed | 2024-12-23T06:35:39Z |
| format | Article |
| id | doaj.art-ad3048e975874b0ebabb1080f23378d2 |
| institution | Directory Open Access Journal |
| issn | 2005-6419 2005-7563 |
| language | English |
| last_indexed | 2024-12-23T06:35:39Z |
| publishDate | 2010-02-01 |
| publisher | Korean Society of Anesthesiologists |
| record_format | Article |
| series | Korean Journal of Anesthesiology |
| spelling | doaj.art-ad3048e975874b0ebabb1080f23378d22022-12-21T17:56:48ZengKorean Society of AnesthesiologistsKorean Journal of Anesthesiology2005-64192005-75632010-02-0158211712110.4097/kjae.2010.58.2.1176836The incidence of cough induced by remifentanil during anesthetic induction was decreased by graded escalation of the remifentanil concentrationJi Hun Lim0Sie Jeong Ryu1Young Soo Lim2Department of Anesthesiology and Pain Medicine, Kosin University College of Medicine, Busan, Korea.Department of Anesthesiology and Pain Medicine, Kosin University College of Medicine, Busan, Korea.Department of Anesthesiology and Pain Medicine, Kosin University College of Medicine, Busan, Korea.BackgroundIt is well known that opioids induce coughing. Many drugs such as lidocaine and ketamine are used to effectively prevent the coughing induced by opioids and this has been revealed to be effective. In this study, we evaluated the preventive effect of a graded escalation of the remifentanil concentration using a target controlled infusion pump and we compared this with the effect of lidocaine.MethodsOne hundred fifty ASA I and II patients who were scheduled for elective surgery were randomly divided into 3 groups. The patients were pretreated with 2% lidocaine 1 mg/kg (Group L) or saline (Group S) and remifentanil infusion (an effect site concentration of 4.0 ng/ml) was followed 1 minute later by using a target controlled infusion pump. Group R was pretreated with saline and this was followed by remifentanil infusion (effect site concentration of 2.0 ng/ml at first and then it was reset to 4.0 ng/ml). We evaluated the incidence, severity and onset time of cough after remifentanil infusion.ResultsThe incidence of coughing was significantly decreased in Group R (6 cases, 12%) and Group L (7 cases, 14%), as compared to that of Group S (17 cases, 34%) (P < 0.05), but there was no significant difference between Group R and Group L. The groups showed no significant difference in the severity and the onset time of coughing.ConclusionsThis study demonstrated that administering graded escalation of the remifentanil concentration suppresses remifentanil-induced coughing as effectively as lidocaine 1 mg/kg pretreatment.http://ekja.org/upload/pdf/kjae-58-117.pdfcoughgraded escalationlidocaineremifentanil |
| spellingShingle | Ji Hun Lim Sie Jeong Ryu Young Soo Lim The incidence of cough induced by remifentanil during anesthetic induction was decreased by graded escalation of the remifentanil concentration Korean Journal of Anesthesiology cough graded escalation lidocaine remifentanil |
| title | The incidence of cough induced by remifentanil during anesthetic induction was decreased by graded escalation of the remifentanil concentration |
| title_full | The incidence of cough induced by remifentanil during anesthetic induction was decreased by graded escalation of the remifentanil concentration |
| title_fullStr | The incidence of cough induced by remifentanil during anesthetic induction was decreased by graded escalation of the remifentanil concentration |
| title_full_unstemmed | The incidence of cough induced by remifentanil during anesthetic induction was decreased by graded escalation of the remifentanil concentration |
| title_short | The incidence of cough induced by remifentanil during anesthetic induction was decreased by graded escalation of the remifentanil concentration |
| title_sort | incidence of cough induced by remifentanil during anesthetic induction was decreased by graded escalation of the remifentanil concentration |
| topic | cough graded escalation lidocaine remifentanil |
| url | http://ekja.org/upload/pdf/kjae-58-117.pdf |
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