Association of a Single Nucleotide Variant in <i>TERT</i> with Airway Disease in Japanese Rheumatoid Arthritis Patients
Interstitial lung disease and airway disease (AD) are often complicated with rheumatoid arthritis (RA) and have a poor prognosis. Several studies reported genetic associations with interstitial lung disease in RA. However, few genetic studies have examined the susceptibility to AD in RA patients. He...
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MDPI AG
2023-11-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/14/11/2084 |
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| author | Takashi Higuchi Shomi Oka Hiroshi Furukawa Kota Shimada Shinichiro Tsunoda Satoshi Ito Akira Okamoto Misuzu Fujimori Tadashi Nakamura Masao Katayama Koichiro Saisho Satoshi Shinohara Toshihiro Matsui Kiyoshi Migita Shouhei Nagaoka Shigeto Tohma |
| author_facet | Takashi Higuchi Shomi Oka Hiroshi Furukawa Kota Shimada Shinichiro Tsunoda Satoshi Ito Akira Okamoto Misuzu Fujimori Tadashi Nakamura Masao Katayama Koichiro Saisho Satoshi Shinohara Toshihiro Matsui Kiyoshi Migita Shouhei Nagaoka Shigeto Tohma |
| author_sort | Takashi Higuchi |
| collection | DOAJ |
| description | Interstitial lung disease and airway disease (AD) are often complicated with rheumatoid arthritis (RA) and have a poor prognosis. Several studies reported genetic associations with interstitial lung disease in RA. However, few genetic studies have examined the susceptibility to AD in RA patients. Here, we investigated whether single nucleotide variants susceptible to idiopathic pulmonary fibrosis might be associated with interstitial lung disease or AD in Japanese RA patients. Genotyping of rs2736100 [C/A] in <i>TERT</i> and rs1278769 [G/A] in <i>ATP11A</i> was conducted in 98 RA patients with usual interstitial pneumonia, 120 with nonspecific interstitial pneumonia (NSIP), 227 with AD, and 422 without chronic lung disease using TaqMan assays. An association with AD in RA was found for rs2736100 (<i>p</i> = 0.0043, Pc = 0.0129, odds ratio [OR] 1.40, 95% confidence interval [CI] 1.11–1.77). <i>ATP11A</i> rs1278769 was significantly associated with NSIP in older RA patients (>65 years, <i>p</i> = 0.0010, OR 2.15, 95% CI 1.35–3.40). This study first reported an association of rs2736100 with AD in RA patients and <i>ATP11A</i> rs1278769 with NSIP in older RA patients. |
| first_indexed | 2024-03-09T16:48:09Z |
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| language | English |
| last_indexed | 2024-03-09T16:48:09Z |
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| series | Genes |
| spelling | doaj.art-ad30d7b2a6464206b3771edbb065322a2023-11-24T14:44:09ZengMDPI AGGenes2073-44252023-11-011411208410.3390/genes14112084Association of a Single Nucleotide Variant in <i>TERT</i> with Airway Disease in Japanese Rheumatoid Arthritis PatientsTakashi Higuchi0Shomi Oka1Hiroshi Furukawa2Kota Shimada3Shinichiro Tsunoda4Satoshi Ito5Akira Okamoto6Misuzu Fujimori7Tadashi Nakamura8Masao Katayama9Koichiro Saisho10Satoshi Shinohara11Toshihiro Matsui12Kiyoshi Migita13Shouhei Nagaoka14Shigeto Tohma15Department of Clinical Research, NHO Tokyo National Hospital, 3-1-1 Takeoka, Kiyose 204-8585, JapanDepartment of Clinical Research, NHO Tokyo National Hospital, 3-1-1 Takeoka, Kiyose 204-8585, JapanDepartment of Clinical Research, NHO Tokyo National Hospital, 3-1-1 Takeoka, Kiyose 204-8585, JapanDepartment of Rheumatology, NHO Sagamihara National Hospital, 18-1 Sakuradai, Minami-ku, Sagamihara 252-0392, JapanDivision of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, JapanDepartment of Rheumatology, Niigata Rheumatic Center, 1-2-8 Hon-cho, Shibata 957-0054, JapanDepartment of Rheumatology, NHO Himeji Medical Center, 68 Hon-machi, Himeji 670-8520, JapanDepartment of Rheumatology, NHO Himeji Medical Center, 68 Hon-machi, Himeji 670-8520, JapanDepartment of Rheumatology, Sakurajyuji Hospital, 1-1-1 Miyukikibe, Minami-ku, Kumamoto 861-4173, JapanDepartment of Internal Medicine, NHO Nagoya Medical Center, 4-1-1 Sannomaru, Naka-ku, Nagoya 460-0001, JapanDepartment of Orthopedics/Rheumatology, NHO Miyakonojo Medical Center, 5033-1 Iwayoshi-cho, Miyakonojo 885-0014, JapanTochigi Rheumatology Clinic, 1-1-9 Ekimaedori, Utsunomiya 321-0964, JapanClinical Research Center for Allergy and Rheumatology, NHO Sagamihara National Hospital, 18-1 Sakuradai, Minami-ku, Sagamihara 252-0392, JapanClinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, Omura 856-8562, JapanDepartment of Rheumatology, Yokohama Minami Kyosai Hospital, 1-21-1 Rokuura-higashi, Kanazawa-ku, Yokohama 236-0037, JapanDepartment of Clinical Research, NHO Tokyo National Hospital, 3-1-1 Takeoka, Kiyose 204-8585, JapanInterstitial lung disease and airway disease (AD) are often complicated with rheumatoid arthritis (RA) and have a poor prognosis. Several studies reported genetic associations with interstitial lung disease in RA. However, few genetic studies have examined the susceptibility to AD in RA patients. Here, we investigated whether single nucleotide variants susceptible to idiopathic pulmonary fibrosis might be associated with interstitial lung disease or AD in Japanese RA patients. Genotyping of rs2736100 [C/A] in <i>TERT</i> and rs1278769 [G/A] in <i>ATP11A</i> was conducted in 98 RA patients with usual interstitial pneumonia, 120 with nonspecific interstitial pneumonia (NSIP), 227 with AD, and 422 without chronic lung disease using TaqMan assays. An association with AD in RA was found for rs2736100 (<i>p</i> = 0.0043, Pc = 0.0129, odds ratio [OR] 1.40, 95% confidence interval [CI] 1.11–1.77). <i>ATP11A</i> rs1278769 was significantly associated with NSIP in older RA patients (>65 years, <i>p</i> = 0.0010, OR 2.15, 95% CI 1.35–3.40). This study first reported an association of rs2736100 with AD in RA patients and <i>ATP11A</i> rs1278769 with NSIP in older RA patients.https://www.mdpi.com/2073-4425/14/11/2084single nucleotide variantairway diseasenonspecific interstitial pneumoniarheumatoid arthritisgenetic association |
| spellingShingle | Takashi Higuchi Shomi Oka Hiroshi Furukawa Kota Shimada Shinichiro Tsunoda Satoshi Ito Akira Okamoto Misuzu Fujimori Tadashi Nakamura Masao Katayama Koichiro Saisho Satoshi Shinohara Toshihiro Matsui Kiyoshi Migita Shouhei Nagaoka Shigeto Tohma Association of a Single Nucleotide Variant in <i>TERT</i> with Airway Disease in Japanese Rheumatoid Arthritis Patients Genes single nucleotide variant airway disease nonspecific interstitial pneumonia rheumatoid arthritis genetic association |
| title | Association of a Single Nucleotide Variant in <i>TERT</i> with Airway Disease in Japanese Rheumatoid Arthritis Patients |
| title_full | Association of a Single Nucleotide Variant in <i>TERT</i> with Airway Disease in Japanese Rheumatoid Arthritis Patients |
| title_fullStr | Association of a Single Nucleotide Variant in <i>TERT</i> with Airway Disease in Japanese Rheumatoid Arthritis Patients |
| title_full_unstemmed | Association of a Single Nucleotide Variant in <i>TERT</i> with Airway Disease in Japanese Rheumatoid Arthritis Patients |
| title_short | Association of a Single Nucleotide Variant in <i>TERT</i> with Airway Disease in Japanese Rheumatoid Arthritis Patients |
| title_sort | association of a single nucleotide variant in i tert i with airway disease in japanese rheumatoid arthritis patients |
| topic | single nucleotide variant airway disease nonspecific interstitial pneumonia rheumatoid arthritis genetic association |
| url | https://www.mdpi.com/2073-4425/14/11/2084 |
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