Directed Induction of Functional Multi-ciliated Cells in Proximal Airway Epithelial Spheroids from Human Pluripotent Stem Cells

Directed Induction of Functional Multi-ciliated Cells in Proximal Airway Epithelial Spheroids from Human Pluripotent Stem Cells

Multi-ciliated airway cells (MCACs) play a role in mucociliary clearance of the lung. However, the efficient induction of functional MCACs from human pluripotent stem cells has not yet been reported. Using carboxypeptidase M (CPM) as a surface marker of NKX2-1+-ventralized anterior foregut endoderm...

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Bibliographic Details
Main Authors:	Satoshi Konishi, Shimpei Gotoh, Kazuhiro Tateishi, Yuki Yamamoto, Yohei Korogi, Tadao Nagasaki, Hisako Matsumoto, Shigeo Muro, Toyohiro Hirai, Isao Ito, Sachiko Tsukita, Michiaki Mishima
Format:	Article
Language:	English
Published:	Elsevier 2016-01-01
Series:	Stem Cell Reports
Online Access:	http://www.sciencedirect.com/science/article/pii/S221367111500346X

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