Functional brain alterations in Cushing’s syndrome
Cognitive impairment and affective disorders are common in patients with Cushing’s syndrome (CS). In fact, as an effect of prolonged cortisol excess on the brain, patients with CS often have memory problems, concentration difficulties, impaired attention and executive function, that are not always r...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1163482/full |
| _version_ | 1797843261613670400 |
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| author | Eleni Papakokkinou Eleni Papakokkinou Oskar Ragnarsson Oskar Ragnarsson Oskar Ragnarsson |
| author_facet | Eleni Papakokkinou Eleni Papakokkinou Oskar Ragnarsson Oskar Ragnarsson Oskar Ragnarsson |
| author_sort | Eleni Papakokkinou |
| collection | DOAJ |
| description | Cognitive impairment and affective disorders are common in patients with Cushing’s syndrome (CS). In fact, as an effect of prolonged cortisol excess on the brain, patients with CS often have memory problems, concentration difficulties, impaired attention and executive function, that are not always reversible following successful treatment. Neuroimaging is essential for understanding the deleterious effects of hypercortisolism on the brain. In CS, structural alterations have been observed, including reduction of hippocampal volume, amygdala and the prefrontal cortex. The aim of this article is to summarize results from studies that have used functional magnetic resonance imaging (fMRI) to study functional brain alterations in patients with CS. In these studies, alterations in brain areas and networks essential for cognitive function, emotional processing, and executive function have been observed, both in patients with active CS as well as following treatment. Nevertheless, longitudinal studies with a comprehensive evaluation of functional brain alterations and neurocognitive evaluation are still needed to determine whether the apparent deleterious effects of hypercortisolism on the brain are reversible or not. |
| first_indexed | 2024-04-09T17:02:18Z |
| format | Article |
| id | doaj.art-ad320f8346c74c0786276447a367d3ac |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-09T17:02:18Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-ad320f8346c74c0786276447a367d3ac2023-04-21T04:44:12ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-04-011410.3389/fendo.2023.11634821163482Functional brain alterations in Cushing’s syndromeEleni Papakokkinou0Eleni Papakokkinou1Oskar Ragnarsson2Oskar Ragnarsson3Oskar Ragnarsson4Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenDepartment of Endocrinology, Sahlgrenska University Hospital, Gothenburg, SwedenDepartment of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenDepartment of Endocrinology, Sahlgrenska University Hospital, Gothenburg, SwedenWallenberg Center for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, SwedenCognitive impairment and affective disorders are common in patients with Cushing’s syndrome (CS). In fact, as an effect of prolonged cortisol excess on the brain, patients with CS often have memory problems, concentration difficulties, impaired attention and executive function, that are not always reversible following successful treatment. Neuroimaging is essential for understanding the deleterious effects of hypercortisolism on the brain. In CS, structural alterations have been observed, including reduction of hippocampal volume, amygdala and the prefrontal cortex. The aim of this article is to summarize results from studies that have used functional magnetic resonance imaging (fMRI) to study functional brain alterations in patients with CS. In these studies, alterations in brain areas and networks essential for cognitive function, emotional processing, and executive function have been observed, both in patients with active CS as well as following treatment. Nevertheless, longitudinal studies with a comprehensive evaluation of functional brain alterations and neurocognitive evaluation are still needed to determine whether the apparent deleterious effects of hypercortisolism on the brain are reversible or not.https://www.frontiersin.org/articles/10.3389/fendo.2023.1163482/fullCushing’s syndromefunctional connectivitytask-related functional magnetic resonance imagingresting-state functional magnetic resonance imagingprefrontal cortexhippocampus |
| spellingShingle | Eleni Papakokkinou Eleni Papakokkinou Oskar Ragnarsson Oskar Ragnarsson Oskar Ragnarsson Functional brain alterations in Cushing’s syndrome Frontiers in Endocrinology Cushing’s syndrome functional connectivity task-related functional magnetic resonance imaging resting-state functional magnetic resonance imaging prefrontal cortex hippocampus |
| title | Functional brain alterations in Cushing’s syndrome |
| title_full | Functional brain alterations in Cushing’s syndrome |
| title_fullStr | Functional brain alterations in Cushing’s syndrome |
| title_full_unstemmed | Functional brain alterations in Cushing’s syndrome |
| title_short | Functional brain alterations in Cushing’s syndrome |
| title_sort | functional brain alterations in cushing s syndrome |
| topic | Cushing’s syndrome functional connectivity task-related functional magnetic resonance imaging resting-state functional magnetic resonance imaging prefrontal cortex hippocampus |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1163482/full |
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