Expression and prognostic significance of cox-2 and p-53 in hodgkin lymphomas: a retrospective study
<p>Abstract</p> <p>Background</p> <p>Cyclooxygenase (cox) is the rate-limiting enzyme, which catalyzes the conversion of arachidonic acid into prostaglandins and contributes to the inflammatory process. Cyclooxygenase-2 (cox-2), which is one of the two isoforms, plays a...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2010-03-01
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| Series: | Diagnostic Pathology |
| Online Access: | http://www.diagnosticpathology.org/content/5/1/19 |
| _version_ | 1818231541798535168 |
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| author | Karadayi Nimet Kaygusuz Isik Gumus Mahmut Bozkurt Suheyla Barisik Nagehan O Bas Emine Bayik Mahmut Tecimer Tulay |
| author_facet | Karadayi Nimet Kaygusuz Isik Gumus Mahmut Bozkurt Suheyla Barisik Nagehan O Bas Emine Bayik Mahmut Tecimer Tulay |
| author_sort | Karadayi Nimet |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Cyclooxygenase (cox) is the rate-limiting enzyme, which catalyzes the conversion of arachidonic acid into prostaglandins and contributes to the inflammatory process. Cyclooxygenase-2 (cox-2), which is one of the two isoforms, plays a role in tumor progression and carcinogenesis. p53 contributes to apoptosis, DNA renewal and cell cycle. Studies concerning the relationship of cox-2 and p53 expressions and carcinogenesis are available, but the association between cox-2 and p53 in Hodgkin lymphoma (HL) is not exactly known.</p> <p>In our study, we examined the association of cox-2 and p53 expression, with age, stage, histopathological subtype, and survival in HL. We also examined correlation between cox-2 and p53 expression.</p> <p>Methods</p> <p>Cox-2 and p53 expressions in Hodgkin-Reed Sternberg cells (HRS) were examined in 54 patients with HL depending on cox-2 expression, stained cases were classified as positive, and unstained cases as negative. Nuclear staining of HRS cells with p53 was evaluated as positive. The classifications of positivity were as follows: negative if<10%; (1+) if 10-25%; (2+) if 25-50%; (3+) if 50-75%, (4+) if >75%.</p> <p>Results</p> <p>Cox-2 and p53 expressions were found in 49 (80%) and 29 (46%) patients, respectively. There were differences between histological subtypes according to cox-2 expression (p = 0.012). Mixed cellular (MC) and nodular sclerosing (NS) subtypes were seen most of the patients and cox-2 expression was evaluated mostly in the mixed cellular subtype.</p> <p>There were no statistically significant relationships between p53 and the histopathological subtypes; or between p53, cox-2 and the factors including stage, age and survival; or between p53 and cox-2 expression (p > 0.05).</p> <p>Conclusion</p> <p>Considering the significant relationship between the cox-2 expression and the subtypes of HL, cox-2 expression is higher in MC and NS subtypes. However the difference between these two subtypes was not significant. This submission must be advocated by studies with large series</p> |
| first_indexed | 2024-12-12T10:52:02Z |
| format | Article |
| id | doaj.art-ad386c9c3049407b8b869a1d18d517b3 |
| institution | Directory Open Access Journal |
| issn | 1746-1596 |
| language | English |
| last_indexed | 2024-12-12T10:52:02Z |
| publishDate | 2010-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Diagnostic Pathology |
| spelling | doaj.art-ad386c9c3049407b8b869a1d18d517b32022-12-22T00:26:45ZengBMCDiagnostic Pathology1746-15962010-03-01511910.1186/1746-1596-5-19Expression and prognostic significance of cox-2 and p-53 in hodgkin lymphomas: a retrospective studyKaradayi NimetKaygusuz IsikGumus MahmutBozkurt SuheylaBarisik Nagehan OBas EmineBayik MahmutTecimer Tulay<p>Abstract</p> <p>Background</p> <p>Cyclooxygenase (cox) is the rate-limiting enzyme, which catalyzes the conversion of arachidonic acid into prostaglandins and contributes to the inflammatory process. Cyclooxygenase-2 (cox-2), which is one of the two isoforms, plays a role in tumor progression and carcinogenesis. p53 contributes to apoptosis, DNA renewal and cell cycle. Studies concerning the relationship of cox-2 and p53 expressions and carcinogenesis are available, but the association between cox-2 and p53 in Hodgkin lymphoma (HL) is not exactly known.</p> <p>In our study, we examined the association of cox-2 and p53 expression, with age, stage, histopathological subtype, and survival in HL. We also examined correlation between cox-2 and p53 expression.</p> <p>Methods</p> <p>Cox-2 and p53 expressions in Hodgkin-Reed Sternberg cells (HRS) were examined in 54 patients with HL depending on cox-2 expression, stained cases were classified as positive, and unstained cases as negative. Nuclear staining of HRS cells with p53 was evaluated as positive. The classifications of positivity were as follows: negative if<10%; (1+) if 10-25%; (2+) if 25-50%; (3+) if 50-75%, (4+) if >75%.</p> <p>Results</p> <p>Cox-2 and p53 expressions were found in 49 (80%) and 29 (46%) patients, respectively. There were differences between histological subtypes according to cox-2 expression (p = 0.012). Mixed cellular (MC) and nodular sclerosing (NS) subtypes were seen most of the patients and cox-2 expression was evaluated mostly in the mixed cellular subtype.</p> <p>There were no statistically significant relationships between p53 and the histopathological subtypes; or between p53, cox-2 and the factors including stage, age and survival; or between p53 and cox-2 expression (p > 0.05).</p> <p>Conclusion</p> <p>Considering the significant relationship between the cox-2 expression and the subtypes of HL, cox-2 expression is higher in MC and NS subtypes. However the difference between these two subtypes was not significant. This submission must be advocated by studies with large series</p>http://www.diagnosticpathology.org/content/5/1/19 |
| spellingShingle | Karadayi Nimet Kaygusuz Isik Gumus Mahmut Bozkurt Suheyla Barisik Nagehan O Bas Emine Bayik Mahmut Tecimer Tulay Expression and prognostic significance of cox-2 and p-53 in hodgkin lymphomas: a retrospective study Diagnostic Pathology |
| title | Expression and prognostic significance of cox-2 and p-53 in hodgkin lymphomas: a retrospective study |
| title_full | Expression and prognostic significance of cox-2 and p-53 in hodgkin lymphomas: a retrospective study |
| title_fullStr | Expression and prognostic significance of cox-2 and p-53 in hodgkin lymphomas: a retrospective study |
| title_full_unstemmed | Expression and prognostic significance of cox-2 and p-53 in hodgkin lymphomas: a retrospective study |
| title_short | Expression and prognostic significance of cox-2 and p-53 in hodgkin lymphomas: a retrospective study |
| title_sort | expression and prognostic significance of cox 2 and p 53 in hodgkin lymphomas a retrospective study |
| url | http://www.diagnosticpathology.org/content/5/1/19 |
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