A target-controlled infusion regimen for reducing remifentanil-induced coughs
BackgroundThis study evaluates the effectiveness of the target-controlled infusion (TCI) of remifentanil through stepwise increases in the effect-site concentration (Ceff) in preventing coughs.MethodsIn a preliminary study, we randomly selected 140 patients to receive remifentanil through two-step i...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Korean Society of Anesthesiologists
2012-07-01
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| Series: | Korean Journal of Anesthesiology |
| Subjects: | |
| Online Access: | http://ekja.org/upload/pdf/kjae-63-30.pdf |
| _version_ | 1818417961880256512 |
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| author | Jong-Yeop Kim Yun Jeong Chae Jin-Soo Kim Yoon-Jeong Park Sang-Kee Min |
| author_facet | Jong-Yeop Kim Yun Jeong Chae Jin-Soo Kim Yoon-Jeong Park Sang-Kee Min |
| author_sort | Jong-Yeop Kim |
| collection | DOAJ |
| description | BackgroundThis study evaluates the effectiveness of the target-controlled infusion (TCI) of remifentanil through stepwise increases in the effect-site concentration (Ceff) in preventing coughs.MethodsIn a preliminary study, we randomly selected 140 patients to receive remifentanil through two-step increases in Ceff (1.0 ng/ml to 4.0 ng/ml: Group R1-4; 2.0 ng/ml to 4.0 ng/ml: Group R2-4). Based on the results of the preliminary study, we employed another sample of 140 patients and implemented a three-step increase in TCI (1.0 ng/ml to 2.0 ng/ml to 4.0 ng/ml: Group R1-2-4). We then compared this treatment with direct targeting based on 4.0 ng/ml TCI (Group R4). We recorded the episodes of coughs, rating them as mild (1-2), moderate (3-4), or severe (5 or more).ResultsIn Group R1-4, one patient (1.5%) coughed during the first step, and five (7.3%) coughed during the second step. In Group R2-4, nine (13.2%) coughed during the first step, but none coughed during the next step. Only one patient had a mild cough during the three-step increase in TCI, that is, patients in Group R1-2-4 were significantly less likely to cough than those in Group R4 (P < 0.001).ConclusionsStepwise increases in the TCI of remifentanil reduced the incidence of remifentanil-induced coughing, and the three-step increase in TCI nearly eliminated remifentanil-induced coughing. |
| first_indexed | 2024-12-14T12:15:06Z |
| format | Article |
| id | doaj.art-ad3c2acc076b4eb198967addd910912d |
| institution | Directory Open Access Journal |
| issn | 2005-6419 2005-7563 |
| language | English |
| last_indexed | 2024-12-14T12:15:06Z |
| publishDate | 2012-07-01 |
| publisher | Korean Society of Anesthesiologists |
| record_format | Article |
| series | Korean Journal of Anesthesiology |
| spelling | doaj.art-ad3c2acc076b4eb198967addd910912d2022-12-21T23:01:39ZengKorean Society of AnesthesiologistsKorean Journal of Anesthesiology2005-64192005-75632012-07-01631303510.4097/kjae.2012.63.1.307425A target-controlled infusion regimen for reducing remifentanil-induced coughsJong-Yeop Kim0Yun Jeong Chae1Jin-Soo Kim2Yoon-Jeong Park3Sang-Kee Min4Department of Anesthesiology and Pain Medicine, Ajou University School of Medicine, Suwon, Korea.Department of Anesthesiology and Pain Medicine, Ajou University School of Medicine, Suwon, Korea.Department of Anesthesiology and Pain Medicine, Ajou University School of Medicine, Suwon, Korea.Department of Anesthesiology and Pain Medicine, Ajou University School of Medicine, Suwon, Korea.Department of Anesthesiology and Pain Medicine, Ajou University School of Medicine, Suwon, Korea.BackgroundThis study evaluates the effectiveness of the target-controlled infusion (TCI) of remifentanil through stepwise increases in the effect-site concentration (Ceff) in preventing coughs.MethodsIn a preliminary study, we randomly selected 140 patients to receive remifentanil through two-step increases in Ceff (1.0 ng/ml to 4.0 ng/ml: Group R1-4; 2.0 ng/ml to 4.0 ng/ml: Group R2-4). Based on the results of the preliminary study, we employed another sample of 140 patients and implemented a three-step increase in TCI (1.0 ng/ml to 2.0 ng/ml to 4.0 ng/ml: Group R1-2-4). We then compared this treatment with direct targeting based on 4.0 ng/ml TCI (Group R4). We recorded the episodes of coughs, rating them as mild (1-2), moderate (3-4), or severe (5 or more).ResultsIn Group R1-4, one patient (1.5%) coughed during the first step, and five (7.3%) coughed during the second step. In Group R2-4, nine (13.2%) coughed during the first step, but none coughed during the next step. Only one patient had a mild cough during the three-step increase in TCI, that is, patients in Group R1-2-4 were significantly less likely to cough than those in Group R4 (P < 0.001).ConclusionsStepwise increases in the TCI of remifentanil reduced the incidence of remifentanil-induced coughing, and the three-step increase in TCI nearly eliminated remifentanil-induced coughing.http://ekja.org/upload/pdf/kjae-63-30.pdfcoughopioid-related disordersremifentanil |
| spellingShingle | Jong-Yeop Kim Yun Jeong Chae Jin-Soo Kim Yoon-Jeong Park Sang-Kee Min A target-controlled infusion regimen for reducing remifentanil-induced coughs Korean Journal of Anesthesiology cough opioid-related disorders remifentanil |
| title | A target-controlled infusion regimen for reducing remifentanil-induced coughs |
| title_full | A target-controlled infusion regimen for reducing remifentanil-induced coughs |
| title_fullStr | A target-controlled infusion regimen for reducing remifentanil-induced coughs |
| title_full_unstemmed | A target-controlled infusion regimen for reducing remifentanil-induced coughs |
| title_short | A target-controlled infusion regimen for reducing remifentanil-induced coughs |
| title_sort | target controlled infusion regimen for reducing remifentanil induced coughs |
| topic | cough opioid-related disorders remifentanil |
| url | http://ekja.org/upload/pdf/kjae-63-30.pdf |
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