Current State of Knowledge Regarding WHO Critical Priority Pathogens: Mechanisms of Resistance and Proposed Solutions through Candidates Such as Essential Oils
The rise of multidrug-resistant (MDR) pathogens has become a global health threat and an economic burden in providing adequate and effective treatment for many infections. This large-scale concern has emerged mainly due to mishandling of antibiotics (ABs) and has resulted in the rapid expansion of a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Plants |
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| Online Access: | https://www.mdpi.com/2223-7747/11/14/1789 |
| _version_ | 1797416393943023616 |
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| author | Bianca Badescu Valentina Buda Mirabela Romanescu Adelina Lombrea Corina Danciu Olivia Dalleur Angele Modupe Dohou Victor Dumitrascu Octavian Cretu Monica Licker Delia Muntean |
| author_facet | Bianca Badescu Valentina Buda Mirabela Romanescu Adelina Lombrea Corina Danciu Olivia Dalleur Angele Modupe Dohou Victor Dumitrascu Octavian Cretu Monica Licker Delia Muntean |
| author_sort | Bianca Badescu |
| collection | DOAJ |
| description | The rise of multidrug-resistant (MDR) pathogens has become a global health threat and an economic burden in providing adequate and effective treatment for many infections. This large-scale concern has emerged mainly due to mishandling of antibiotics (ABs) and has resulted in the rapid expansion of antimicrobial resistance (AMR). Nowadays, there is an urgent need for more potent, non-toxic and effective antimicrobial agents against MDR strains. In this regard, clinicians, pharmacists, microbiologists and the entire scientific community are encouraged to find alternative solutions in treating infectious diseases cause by these strains. In its “10 global issues to track in 2021”, the World Health Organization (WHO) has made fighting drug resistance a priority. It has also issued a list of bacteria that are in urgent need for new ABs. Despite all available resources, researchers are unable to keep the pace of finding novel ABs in the face of emerging MDR strains. Traditional methods are increasingly becoming ineffective, so new approaches need to be considered. In this regard, the general tendency of turning towards natural alternatives has reinforced the interest in essential oils (EOs) as potent antimicrobial agents. Our present article aims to first review the main pathogens classified by WHO as critical in terms of current AMR. The next objective is to summarize the most important and up-to-date aspects of resistance mechanisms to classical antibiotic therapy and to compare them with the latest findings regarding the efficacy of alternative essential oil therapy. |
| first_indexed | 2024-03-09T06:03:36Z |
| format | Article |
| id | doaj.art-ad3d0dde0d11411999bb8887774b74e9 |
| institution | Directory Open Access Journal |
| issn | 2223-7747 |
| language | English |
| last_indexed | 2024-03-09T06:03:36Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Plants |
| spelling | doaj.art-ad3d0dde0d11411999bb8887774b74e92023-12-03T12:06:58ZengMDPI AGPlants2223-77472022-07-011114178910.3390/plants11141789Current State of Knowledge Regarding WHO Critical Priority Pathogens: Mechanisms of Resistance and Proposed Solutions through Candidates Such as Essential OilsBianca Badescu0Valentina Buda1Mirabela Romanescu2Adelina Lombrea3Corina Danciu4Olivia Dalleur5Angele Modupe Dohou6Victor Dumitrascu7Octavian Cretu8Monica Licker9Delia Muntean10Doctoral School, “Victor Babeş” University of Medicine and Pharmacy, 2 Eftimie Murgu Street, 300041 Timisoara, RomaniaFaculty of Pharmacy, “Victor Babeş” University of Medicine and Pharmacy, 2 Eftimie Murgu Street, 300041 Timisoara, RomaniaDoctoral School, “Victor Babeş” University of Medicine and Pharmacy, 2 Eftimie Murgu Street, 300041 Timisoara, RomaniaFaculty of Pharmacy, “Victor Babeş” University of Medicine and Pharmacy, 2 Eftimie Murgu Street, 300041 Timisoara, RomaniaFaculty of Pharmacy, “Victor Babeş” University of Medicine and Pharmacy, 2 Eftimie Murgu Street, 300041 Timisoara, RomaniaLouvain Drug Research Institute, Université Catholique de Louvain, Avenue Emmanuel Mounier 73, 1200 Brussels, BelgiumLouvain Drug Research Institute, Université Catholique de Louvain, Avenue Emmanuel Mounier 73, 1200 Brussels, BelgiumFaculty of Medicine, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, RomaniaFaculty of Medicine, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, RomaniaFaculty of Medicine, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, RomaniaResearch Center for Pharmaco-Toxicological Evaluation, “Victor Babes” University of Medicine and Phamacy, 2 Eftimie Murgu Square, 300041 Timisoara, RomaniaThe rise of multidrug-resistant (MDR) pathogens has become a global health threat and an economic burden in providing adequate and effective treatment for many infections. This large-scale concern has emerged mainly due to mishandling of antibiotics (ABs) and has resulted in the rapid expansion of antimicrobial resistance (AMR). Nowadays, there is an urgent need for more potent, non-toxic and effective antimicrobial agents against MDR strains. In this regard, clinicians, pharmacists, microbiologists and the entire scientific community are encouraged to find alternative solutions in treating infectious diseases cause by these strains. In its “10 global issues to track in 2021”, the World Health Organization (WHO) has made fighting drug resistance a priority. It has also issued a list of bacteria that are in urgent need for new ABs. Despite all available resources, researchers are unable to keep the pace of finding novel ABs in the face of emerging MDR strains. Traditional methods are increasingly becoming ineffective, so new approaches need to be considered. In this regard, the general tendency of turning towards natural alternatives has reinforced the interest in essential oils (EOs) as potent antimicrobial agents. Our present article aims to first review the main pathogens classified by WHO as critical in terms of current AMR. The next objective is to summarize the most important and up-to-date aspects of resistance mechanisms to classical antibiotic therapy and to compare them with the latest findings regarding the efficacy of alternative essential oil therapy.https://www.mdpi.com/2223-7747/11/14/1789healthcare associated infectionsantimicrobial resistanceMDR strains<i>Acinetobacter baumannii</i><i>Pseudomonas aeruginosa</i><i>Klebsiella pneumoniae</i> |
| spellingShingle | Bianca Badescu Valentina Buda Mirabela Romanescu Adelina Lombrea Corina Danciu Olivia Dalleur Angele Modupe Dohou Victor Dumitrascu Octavian Cretu Monica Licker Delia Muntean Current State of Knowledge Regarding WHO Critical Priority Pathogens: Mechanisms of Resistance and Proposed Solutions through Candidates Such as Essential Oils Plants healthcare associated infections antimicrobial resistance MDR strains <i>Acinetobacter baumannii</i> <i>Pseudomonas aeruginosa</i> <i>Klebsiella pneumoniae</i> |
| title | Current State of Knowledge Regarding WHO Critical Priority Pathogens: Mechanisms of Resistance and Proposed Solutions through Candidates Such as Essential Oils |
| title_full | Current State of Knowledge Regarding WHO Critical Priority Pathogens: Mechanisms of Resistance and Proposed Solutions through Candidates Such as Essential Oils |
| title_fullStr | Current State of Knowledge Regarding WHO Critical Priority Pathogens: Mechanisms of Resistance and Proposed Solutions through Candidates Such as Essential Oils |
| title_full_unstemmed | Current State of Knowledge Regarding WHO Critical Priority Pathogens: Mechanisms of Resistance and Proposed Solutions through Candidates Such as Essential Oils |
| title_short | Current State of Knowledge Regarding WHO Critical Priority Pathogens: Mechanisms of Resistance and Proposed Solutions through Candidates Such as Essential Oils |
| title_sort | current state of knowledge regarding who critical priority pathogens mechanisms of resistance and proposed solutions through candidates such as essential oils |
| topic | healthcare associated infections antimicrobial resistance MDR strains <i>Acinetobacter baumannii</i> <i>Pseudomonas aeruginosa</i> <i>Klebsiella pneumoniae</i> |
| url | https://www.mdpi.com/2223-7747/11/14/1789 |
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