Tunable Separation of Nanoparticles in a Continuous Flow Using Standing Surface Acoustic Wave
Manipulating micro and nano-biological particles like extracellular vehicles (EVs), without extracting them from their biological media, presents a big challenge for diagnosis purposes. Here we present the design and fabrication of a sorting device based on the combination of microfluidic and electr...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
IFSA Publishing, S.L.
2019-11-01
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| Series: | Sensors & Transducers |
| Subjects: | |
| Online Access: | https://sensorsportal.com/HTML/DIGEST/november_2019/Vol_238/P_3137.pdf |
| Summary: | Manipulating micro and nano-biological particles like extracellular vehicles (EVs), without extracting them from their biological media, presents a big challenge for diagnosis purposes. Here we present the design and fabrication of a sorting device based on the combination of microfluidic and electroacoustic modules that is capable of aligning and sorting submicron biological particles according to their size, compressibility or mass density, all in a tunable way. The device relies on a lithium niobate (LN) substrate to generate acoustic waves assembled with a micromachined glass layer for microfluidic circuits. The interference between the two surface acoustic waves (SAWs) generated by interdigitated transducers (IDTs) create a distribution of an acoustic radiation force (ARF). This force affects differently particles depending on their physical proprieties. The device is powered by an electronic circuit with a phase shifter to move the node of the standing surface acoustic wave (SSAW) along the channel width. When the device is powered at resonance frequency of the IDTs, experiment shows submicron particles alignment along the channel. By shifting the electrical signal between the two IDTs we can translate the pressure node at any targeted position in the channel width. The particles are then driven to one selected outlet. |
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| ISSN: | 2306-8515 1726-5479 |