This is Your Brain, and This is Your Brain on Atrial Fibrillation: The Roles of Cardiac Malperfusion Events and Vascular Dysfunction in Cognitive Impairment
AF is an independent and strong predictor of long-term cognitive decline. However, the mechanism for this cognitive decline is difficult to define and likely multifactorial, leading to many different hypotheses. Examples include macro- or microvascular stroke events, biochemical changes to the blood...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Radcliffe Medical Media
2023-01-01
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| Series: | Arrhythmia & Electrophysiology Review |
| Online Access: | https://www.aerjournal.com/articles/your-brain-and-your-brain-atrial-fibrillation-roles-cardiac-malperfusion-events-and |
| _version_ | 1827948495868264448 |
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| author | Brian Zenger Scott Rizzi Benjamin A. Steinberg Ravi Ranjan T. Jared Bunch |
| author_facet | Brian Zenger Scott Rizzi Benjamin A. Steinberg Ravi Ranjan T. Jared Bunch |
| author_sort | Brian Zenger |
| collection | DOAJ |
| description | AF is an independent and strong predictor of long-term cognitive decline. However, the mechanism for this cognitive decline is difficult to define and likely multifactorial, leading to many different hypotheses. Examples include macro- or microvascular stroke events, biochemical changes to the blood–brain barrier related to anticoagulation, or hypo-hyperperfusion events. This review explores and discusses the hypothesis that AF contributes to cognitive decline and dementia through hypo-hyperperfusion events occurring during cardiac arrhythmias. We briefly explain several brain perfusion imaging techniques and further examine the novel findings associated with changes in brain perfusion in patients with AF. Finally, we discuss the implications and areas requiring more research to further understand and treat patients with cognitive decline related to AF. |
| first_indexed | 2024-04-09T12:56:15Z |
| format | Article |
| id | doaj.art-ad3f2132b27840fbbdd9f760a562ce67 |
| institution | Directory Open Access Journal |
| issn | 2050-3369 2050-3377 |
| language | English |
| last_indexed | 2024-04-09T12:56:15Z |
| publishDate | 2023-01-01 |
| publisher | Radcliffe Medical Media |
| record_format | Article |
| series | Arrhythmia & Electrophysiology Review |
| spelling | doaj.art-ad3f2132b27840fbbdd9f760a562ce672023-05-13T16:05:09ZengRadcliffe Medical MediaArrhythmia & Electrophysiology Review2050-33692050-33772023-01-011210.15420/aer.2022.29This is Your Brain, and This is Your Brain on Atrial Fibrillation: The Roles of Cardiac Malperfusion Events and Vascular Dysfunction in Cognitive ImpairmentBrian Zenger0Scott Rizzi1Benjamin A. Steinberg2Ravi Ranjan3T. Jared Bunch4School of Medicine, University of Utah, SLC, UT, USDepartment of Internal Medicine, University of Utah Health Sciences, SLC, UT, USDivision of Cardiovascular Medicine, University of Utah Health Sciences, SLC, UT, USDivision of Cardiovascular Medicine, University of Utah Health Sciences, SLC, UT, USDivision of Cardiovascular Medicine, University of Utah Health Sciences, SLC, UT, USAF is an independent and strong predictor of long-term cognitive decline. However, the mechanism for this cognitive decline is difficult to define and likely multifactorial, leading to many different hypotheses. Examples include macro- or microvascular stroke events, biochemical changes to the blood–brain barrier related to anticoagulation, or hypo-hyperperfusion events. This review explores and discusses the hypothesis that AF contributes to cognitive decline and dementia through hypo-hyperperfusion events occurring during cardiac arrhythmias. We briefly explain several brain perfusion imaging techniques and further examine the novel findings associated with changes in brain perfusion in patients with AF. Finally, we discuss the implications and areas requiring more research to further understand and treat patients with cognitive decline related to AF.https://www.aerjournal.com/articles/your-brain-and-your-brain-atrial-fibrillation-roles-cardiac-malperfusion-events-and |
| spellingShingle | Brian Zenger Scott Rizzi Benjamin A. Steinberg Ravi Ranjan T. Jared Bunch This is Your Brain, and This is Your Brain on Atrial Fibrillation: The Roles of Cardiac Malperfusion Events and Vascular Dysfunction in Cognitive Impairment Arrhythmia & Electrophysiology Review |
| title | This is Your Brain, and This is Your Brain on Atrial Fibrillation: The Roles of Cardiac Malperfusion Events and Vascular Dysfunction in Cognitive Impairment |
| title_full | This is Your Brain, and This is Your Brain on Atrial Fibrillation: The Roles of Cardiac Malperfusion Events and Vascular Dysfunction in Cognitive Impairment |
| title_fullStr | This is Your Brain, and This is Your Brain on Atrial Fibrillation: The Roles of Cardiac Malperfusion Events and Vascular Dysfunction in Cognitive Impairment |
| title_full_unstemmed | This is Your Brain, and This is Your Brain on Atrial Fibrillation: The Roles of Cardiac Malperfusion Events and Vascular Dysfunction in Cognitive Impairment |
| title_short | This is Your Brain, and This is Your Brain on Atrial Fibrillation: The Roles of Cardiac Malperfusion Events and Vascular Dysfunction in Cognitive Impairment |
| title_sort | this is your brain and this is your brain on atrial fibrillation the roles of cardiac malperfusion events and vascular dysfunction in cognitive impairment |
| url | https://www.aerjournal.com/articles/your-brain-and-your-brain-atrial-fibrillation-roles-cardiac-malperfusion-events-and |
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