Enhancement of corrosion resistance and biocompatibility of Mg-Nd-Zn-Zr alloy achieved with phosphate coating for vascular stent application
We have developed a convenient chemical conversion method of preparing a Mg3(PO4)2 coating with a lamellar structure of about 1–5 μm width on Mg-Nd-Zn-Zr (denoted as JDBM) alloy, aiming to improve the corrosion resistance and biological response. The protective effect of the phosphate coating on JDB...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-05-01
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| Series: | Journal of Materials Research and Technology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2238785420311881 |
| _version_ | 1818528057132056576 |
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| author | Lin Mao Hongwang Zhu Li Chen Hao Zhou Guangyin Yuan Chengli Song |
| author_facet | Lin Mao Hongwang Zhu Li Chen Hao Zhou Guangyin Yuan Chengli Song |
| author_sort | Lin Mao |
| collection | DOAJ |
| description | We have developed a convenient chemical conversion method of preparing a Mg3(PO4)2 coating with a lamellar structure of about 1–5 μm width on Mg-Nd-Zn-Zr (denoted as JDBM) alloy, aiming to improve the corrosion resistance and biological response. The protective effect of the phosphate coating on JDBM alloy leads to an increase in corrosion resistance of about 25% from 0.337 ± 0.021 to 0.253 ± 0.047 mm y−1. A systematic study on in vitro cytocompatibility test shows that the phosphate coated JDBM has minimal negative effect on human umbilical vein endothelial cells (HUVECs) viability, growth and proliferation, and the coating also presents a favorable affinity for HUVECs by supporting higher adherent cell density and sufficient cell spreading. In addition, the investigation of in vitro hemocompatibility confirms reduced hemolysis ratio and excellent anti-platelet adhesion property of the phosphate coated JDBM. Furthermore, this study also presents our more recent efforts to develop an in-depth understanding of the mechanism which is involving anti-platelet adhesion on the surface of biodegradable Mg substrate. |
| first_indexed | 2024-12-11T06:44:39Z |
| format | Article |
| id | doaj.art-ad3f31fbd4954987961434d5b382e71e |
| institution | Directory Open Access Journal |
| issn | 2238-7854 |
| language | English |
| last_indexed | 2024-12-11T06:44:39Z |
| publishDate | 2020-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Materials Research and Technology |
| spelling | doaj.art-ad3f31fbd4954987961434d5b382e71e2022-12-22T01:17:08ZengElsevierJournal of Materials Research and Technology2238-78542020-05-019364096419Enhancement of corrosion resistance and biocompatibility of Mg-Nd-Zn-Zr alloy achieved with phosphate coating for vascular stent applicationLin Mao0Hongwang Zhu1Li Chen2Hao Zhou3Guangyin Yuan4Chengli Song5Shanghai Institute for Minimally Invasive Therapy, School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China; National Engineering Research Center of Light Alloys Net Forming and State Key Laboratory of Metal Matrix Composite, Shanghai Jiao Tong University, Shanghai 200240, ChinaShanghai Institute for Minimally Invasive Therapy, School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, ChinaShanghai Institute for Minimally Invasive Therapy, School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, ChinaNano and Heterogeneous Materials Center, School of Materials Science and Engineering, Nanjing University of Science and Technology, Nanjing 210094, ChinaNational Engineering Research Center of Light Alloys Net Forming and State Key Laboratory of Metal Matrix Composite, Shanghai Jiao Tong University, Shanghai 200240, China; Corresponding authors.Shanghai Institute for Minimally Invasive Therapy, School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China; Corresponding authors.We have developed a convenient chemical conversion method of preparing a Mg3(PO4)2 coating with a lamellar structure of about 1–5 μm width on Mg-Nd-Zn-Zr (denoted as JDBM) alloy, aiming to improve the corrosion resistance and biological response. The protective effect of the phosphate coating on JDBM alloy leads to an increase in corrosion resistance of about 25% from 0.337 ± 0.021 to 0.253 ± 0.047 mm y−1. A systematic study on in vitro cytocompatibility test shows that the phosphate coated JDBM has minimal negative effect on human umbilical vein endothelial cells (HUVECs) viability, growth and proliferation, and the coating also presents a favorable affinity for HUVECs by supporting higher adherent cell density and sufficient cell spreading. In addition, the investigation of in vitro hemocompatibility confirms reduced hemolysis ratio and excellent anti-platelet adhesion property of the phosphate coated JDBM. Furthermore, this study also presents our more recent efforts to develop an in-depth understanding of the mechanism which is involving anti-platelet adhesion on the surface of biodegradable Mg substrate.http://www.sciencedirect.com/science/article/pii/S2238785420311881Biodegradable Mg alloySurface coatingCorrosion resistanceCytocompatibilityHemocompatibility |
| spellingShingle | Lin Mao Hongwang Zhu Li Chen Hao Zhou Guangyin Yuan Chengli Song Enhancement of corrosion resistance and biocompatibility of Mg-Nd-Zn-Zr alloy achieved with phosphate coating for vascular stent application Journal of Materials Research and Technology Biodegradable Mg alloy Surface coating Corrosion resistance Cytocompatibility Hemocompatibility |
| title | Enhancement of corrosion resistance and biocompatibility of Mg-Nd-Zn-Zr alloy achieved with phosphate coating for vascular stent application |
| title_full | Enhancement of corrosion resistance and biocompatibility of Mg-Nd-Zn-Zr alloy achieved with phosphate coating for vascular stent application |
| title_fullStr | Enhancement of corrosion resistance and biocompatibility of Mg-Nd-Zn-Zr alloy achieved with phosphate coating for vascular stent application |
| title_full_unstemmed | Enhancement of corrosion resistance and biocompatibility of Mg-Nd-Zn-Zr alloy achieved with phosphate coating for vascular stent application |
| title_short | Enhancement of corrosion resistance and biocompatibility of Mg-Nd-Zn-Zr alloy achieved with phosphate coating for vascular stent application |
| title_sort | enhancement of corrosion resistance and biocompatibility of mg nd zn zr alloy achieved with phosphate coating for vascular stent application |
| topic | Biodegradable Mg alloy Surface coating Corrosion resistance Cytocompatibility Hemocompatibility |
| url | http://www.sciencedirect.com/science/article/pii/S2238785420311881 |
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