Electrocatalytic NAD(P)H regeneration for biosynthesis
The highly efficient chemoselectivity, stereoselectivity, and regioselectivity render enzyme catalysis an ideal pathway for the synthesis of various chemicals in broad applications. While the cofactor of an enzyme is necessary but expensive, the conversed state of the cofactor is not beneficial for...
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Format: | Article |
Language: | English |
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KeAi Communications Co. Ltd.
2024-03-01
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Series: | Green Chemical Engineering |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S2666952823000055 |
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author | Yaoxuan Li Guanhua Liu Weixi Kong Suoqing Zhang Yuemei Bao Hao Zhao Lihui Wang Liya Zhou Yanjun Jiang |
author_facet | Yaoxuan Li Guanhua Liu Weixi Kong Suoqing Zhang Yuemei Bao Hao Zhao Lihui Wang Liya Zhou Yanjun Jiang |
author_sort | Yaoxuan Li |
collection | DOAJ |
description | The highly efficient chemoselectivity, stereoselectivity, and regioselectivity render enzyme catalysis an ideal pathway for the synthesis of various chemicals in broad applications. While the cofactor of an enzyme is necessary but expensive, the conversed state of the cofactor is not beneficial for the positive direction of the reaction. Cofactor regeneration using electrochemical methods has the advantages of simple operation, low cost, easy process monitoring, and easy product separation, and the electrical energy is green and sustainable. Therefore, bioelectrocatalysis has great potential in synthesis by combining electrochemical cofactor regeneration with enzymatic catalysis. In this review, we detail the mechanism of cofactor regeneration and categorize the common electron mediators and enzymes used in cofactor regeneration. The reaction type and the recent progress are summarized in electrochemically coupled enzymatic catalysis. The main challenges of such electroenzymatic catalysis are pointed out and future developments in this field are foreseen. |
first_indexed | 2024-03-08T11:53:34Z |
format | Article |
id | doaj.art-ad412056cff04e468e432cfb7f818e06 |
institution | Directory Open Access Journal |
issn | 2666-9528 |
language | English |
last_indexed | 2024-03-08T11:53:34Z |
publishDate | 2024-03-01 |
publisher | KeAi Communications Co. Ltd. |
record_format | Article |
series | Green Chemical Engineering |
spelling | doaj.art-ad412056cff04e468e432cfb7f818e062024-01-24T05:22:15ZengKeAi Communications Co. Ltd.Green Chemical Engineering2666-95282024-03-0151115Electrocatalytic NAD(P)H regeneration for biosynthesisYaoxuan Li0Guanhua Liu1Weixi Kong2Suoqing Zhang3Yuemei Bao4Hao Zhao5Lihui Wang6Liya Zhou7Yanjun Jiang8National-Local Joint Engineering Laboratory for Energy Conservation in Chemical Process Integration and Resources Utilization, School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin, 300401, ChinaNational-Local Joint Engineering Laboratory for Energy Conservation in Chemical Process Integration and Resources Utilization, School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin, 300401, China; Corresponding author.National-Local Joint Engineering Laboratory for Energy Conservation in Chemical Process Integration and Resources Utilization, School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin, 300401, ChinaNorth China Pharmaceutical Group Corp, Shijiazhuang, 050015, ChinaTianjin Food Research Institute, Tianjin, 301609, ChinaNational-Local Joint Engineering Laboratory for Energy Conservation in Chemical Process Integration and Resources Utilization, School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin, 300401, ChinaNational-Local Joint Engineering Laboratory for Energy Conservation in Chemical Process Integration and Resources Utilization, School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin, 300401, ChinaNational-Local Joint Engineering Laboratory for Energy Conservation in Chemical Process Integration and Resources Utilization, School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin, 300401, ChinaNational-Local Joint Engineering Laboratory for Energy Conservation in Chemical Process Integration and Resources Utilization, School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin, 300401, China; Corresponding author.The highly efficient chemoselectivity, stereoselectivity, and regioselectivity render enzyme catalysis an ideal pathway for the synthesis of various chemicals in broad applications. While the cofactor of an enzyme is necessary but expensive, the conversed state of the cofactor is not beneficial for the positive direction of the reaction. Cofactor regeneration using electrochemical methods has the advantages of simple operation, low cost, easy process monitoring, and easy product separation, and the electrical energy is green and sustainable. Therefore, bioelectrocatalysis has great potential in synthesis by combining electrochemical cofactor regeneration with enzymatic catalysis. In this review, we detail the mechanism of cofactor regeneration and categorize the common electron mediators and enzymes used in cofactor regeneration. The reaction type and the recent progress are summarized in electrochemically coupled enzymatic catalysis. The main challenges of such electroenzymatic catalysis are pointed out and future developments in this field are foreseen.http://www.sciencedirect.com/science/article/pii/S2666952823000055BiosynthesisCofactor regenerationBioelectrocatalysisNAD(P)HElectron mediator |
spellingShingle | Yaoxuan Li Guanhua Liu Weixi Kong Suoqing Zhang Yuemei Bao Hao Zhao Lihui Wang Liya Zhou Yanjun Jiang Electrocatalytic NAD(P)H regeneration for biosynthesis Green Chemical Engineering Biosynthesis Cofactor regeneration Bioelectrocatalysis NAD(P)H Electron mediator |
title | Electrocatalytic NAD(P)H regeneration for biosynthesis |
title_full | Electrocatalytic NAD(P)H regeneration for biosynthesis |
title_fullStr | Electrocatalytic NAD(P)H regeneration for biosynthesis |
title_full_unstemmed | Electrocatalytic NAD(P)H regeneration for biosynthesis |
title_short | Electrocatalytic NAD(P)H regeneration for biosynthesis |
title_sort | electrocatalytic nad p h regeneration for biosynthesis |
topic | Biosynthesis Cofactor regeneration Bioelectrocatalysis NAD(P)H Electron mediator |
url | http://www.sciencedirect.com/science/article/pii/S2666952823000055 |
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