Two SPINK1 Mutations Induce Early-Onset Severe Chronic Pancreatitis
The SPINK1 protein is a potent antiprotease that can inactivate any intrapancreatic trypsin activity that would otherwise induce autodigestion of the pancreas. SPINK1 mutations have been recognized to be associated with chronic pancreatitis in patients without a family history of pancreatitis. We he...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2017-03-01
|
| Series: | Case Reports in Gastroenterology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/456654 |
| _version_ | 1818648529815470080 |
|---|---|
| author | Jean Louis Frossard Michael A. Morris |
| author_facet | Jean Louis Frossard Michael A. Morris |
| author_sort | Jean Louis Frossard |
| collection | DOAJ |
| description | The SPINK1 protein is a potent antiprotease that can inactivate any intrapancreatic trypsin activity that would otherwise induce autodigestion of the pancreas. SPINK1 mutations have been recognized to be associated with chronic pancreatitis in patients without a family history of pancreatitis. We here describe the case of a 24-year-old woman referred to our service for recurrent abdominal pain and search for the cause of chronic calcifying pancreatitis, who was found to carry 2 SPINK1 mutations. |
| first_indexed | 2024-12-17T01:19:53Z |
| format | Article |
| id | doaj.art-ad42c0e5d5d6475f80ad2c2f8d762fbc |
| institution | Directory Open Access Journal |
| issn | 1662-0631 |
| language | English |
| last_indexed | 2024-12-17T01:19:53Z |
| publishDate | 2017-03-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Gastroenterology |
| spelling | doaj.art-ad42c0e5d5d6475f80ad2c2f8d762fbc2022-12-21T22:08:52ZengKarger PublishersCase Reports in Gastroenterology1662-06312017-03-01111858810.1159/000456654456654Two SPINK1 Mutations Induce Early-Onset Severe Chronic PancreatitisJean Louis FrossardMichael A. MorrisThe SPINK1 protein is a potent antiprotease that can inactivate any intrapancreatic trypsin activity that would otherwise induce autodigestion of the pancreas. SPINK1 mutations have been recognized to be associated with chronic pancreatitis in patients without a family history of pancreatitis. We here describe the case of a 24-year-old woman referred to our service for recurrent abdominal pain and search for the cause of chronic calcifying pancreatitis, who was found to carry 2 SPINK1 mutations.http://www.karger.com/Article/FullText/456654SPINK1Acute pancreatitisChronic pancreatitis |
| spellingShingle | Jean Louis Frossard Michael A. Morris Two SPINK1 Mutations Induce Early-Onset Severe Chronic Pancreatitis Case Reports in Gastroenterology SPINK1 Acute pancreatitis Chronic pancreatitis |
| title | Two SPINK1 Mutations Induce Early-Onset Severe Chronic Pancreatitis |
| title_full | Two SPINK1 Mutations Induce Early-Onset Severe Chronic Pancreatitis |
| title_fullStr | Two SPINK1 Mutations Induce Early-Onset Severe Chronic Pancreatitis |
| title_full_unstemmed | Two SPINK1 Mutations Induce Early-Onset Severe Chronic Pancreatitis |
| title_short | Two SPINK1 Mutations Induce Early-Onset Severe Chronic Pancreatitis |
| title_sort | two spink1 mutations induce early onset severe chronic pancreatitis |
| topic | SPINK1 Acute pancreatitis Chronic pancreatitis |
| url | http://www.karger.com/Article/FullText/456654 |
| work_keys_str_mv | AT jeanlouisfrossard twospink1mutationsinduceearlyonsetseverechronicpancreatitis AT michaelamorris twospink1mutationsinduceearlyonsetseverechronicpancreatitis |