Efficacy of polysaccharide iron complex in IDA rats: A comparative study with iron protein succinylate and ferrous succinate
Iron deficiency anemia (IDA) is the most common nutrient-related health problem in the world. There is still a lack of comprehensive comparative study on the efficacies of commonly used iron supplements such as polysaccharide iron complex (PIC), iron protein succinylate (IPS) and ferrous succinate (...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Biomedicine & Pharmacotherapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223017894 |
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| author | Huanhuan Yang Xiaoling Zang Xinyu Jin Jiejun Chen Yinggang Lv Zhihua Lv |
| author_facet | Huanhuan Yang Xiaoling Zang Xinyu Jin Jiejun Chen Yinggang Lv Zhihua Lv |
| author_sort | Huanhuan Yang |
| collection | DOAJ |
| description | Iron deficiency anemia (IDA) is the most common nutrient-related health problem in the world. There is still a lack of comprehensive comparative study on the efficacies of commonly used iron supplements such as polysaccharide iron complex (PIC), iron protein succinylate (IPS) and ferrous succinate (FS) for IDA. In this study, we compared the PIC, IPS and FS efficacies in IDA rats via intragastric administration. The results showed that the three iron supplements had similar efficacies. PIC/IPS/FS at a dose of 15 mg Fe/kg/d for 10 d increased the hematological and serum biochemical parameters to 2.15/2.12/2.18 (Hb), 1.71/1.67/1.69 (RBC), 2.10/2.11/2.12 (HCT), 1.26/1.22/1.22 (MCV), all 1.34 (MCH), 1.15/1.15/1.14 (MCHC), 1.94/1.82/1.91 (SF), 9.75/9.67/9.53 (SI), and 23.30/22.68/21.64 (TS) times, and reduced TIBC to 0.42/0.43/0.44 times, compared to untreated IDA rats. PIC performed slightly better than IPS and FS in restoring MCV level. Meanwhile, the heart, spleen and kidney coefficients reduced to 67%/74%/65% (heart), all 59% (spleen) and 87%/88%/88% (kidney), and the liver coefficient increased to 116%/115%/116%, compared to untreated IDA rats. The liver iron content was found to be more affected by IDA than the spleen iron content. PIC/IPS/FS at 15 mg Fe/kg/d increased organ iron contents to 4.20/3.97/4.03 times (liver) and 1.36/1.24/1.41 times (spleen) within 10 d compared to untreated IDA rats, and PIC-H and FS were slightly better than IPS in restoring spleen iron content. The results of this study can provide useful data information for the comparison of three iron supplements, PIC, IPS and FS. |
| first_indexed | 2024-03-08T16:33:31Z |
| format | Article |
| id | doaj.art-ad42e7a16e5641698f2844b3bb1846e7 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-08T16:33:31Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-ad42e7a16e5641698f2844b3bb1846e72024-01-06T04:37:50ZengElsevierBiomedicine & Pharmacotherapy0753-33222024-01-01170115991Efficacy of polysaccharide iron complex in IDA rats: A comparative study with iron protein succinylate and ferrous succinateHuanhuan Yang0Xiaoling Zang1Xinyu Jin2Jiejun Chen3Yinggang Lv4Zhihua Lv5School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong 266003, ChinaSchool of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong 266003, China; Laboratory of Marine Drugs and Biological Products, Pilot National Laboratory for Marine Science and Technology, Qingdao, Shandong 266235, China; Corresponding author at: School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong 266003, China.School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong 266003, ChinaSPH Qingdao Growful Pharmaceutical Co., Ltd., Qingdao, Shandong 266510, ChinaSPH Qingdao Growful Pharmaceutical Co., Ltd., Qingdao, Shandong 266510, ChinaSchool of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong 266003, China; Laboratory of Marine Drugs and Biological Products, Pilot National Laboratory for Marine Science and Technology, Qingdao, Shandong 266235, ChinaIron deficiency anemia (IDA) is the most common nutrient-related health problem in the world. There is still a lack of comprehensive comparative study on the efficacies of commonly used iron supplements such as polysaccharide iron complex (PIC), iron protein succinylate (IPS) and ferrous succinate (FS) for IDA. In this study, we compared the PIC, IPS and FS efficacies in IDA rats via intragastric administration. The results showed that the three iron supplements had similar efficacies. PIC/IPS/FS at a dose of 15 mg Fe/kg/d for 10 d increased the hematological and serum biochemical parameters to 2.15/2.12/2.18 (Hb), 1.71/1.67/1.69 (RBC), 2.10/2.11/2.12 (HCT), 1.26/1.22/1.22 (MCV), all 1.34 (MCH), 1.15/1.15/1.14 (MCHC), 1.94/1.82/1.91 (SF), 9.75/9.67/9.53 (SI), and 23.30/22.68/21.64 (TS) times, and reduced TIBC to 0.42/0.43/0.44 times, compared to untreated IDA rats. PIC performed slightly better than IPS and FS in restoring MCV level. Meanwhile, the heart, spleen and kidney coefficients reduced to 67%/74%/65% (heart), all 59% (spleen) and 87%/88%/88% (kidney), and the liver coefficient increased to 116%/115%/116%, compared to untreated IDA rats. The liver iron content was found to be more affected by IDA than the spleen iron content. PIC/IPS/FS at 15 mg Fe/kg/d increased organ iron contents to 4.20/3.97/4.03 times (liver) and 1.36/1.24/1.41 times (spleen) within 10 d compared to untreated IDA rats, and PIC-H and FS were slightly better than IPS in restoring spleen iron content. The results of this study can provide useful data information for the comparison of three iron supplements, PIC, IPS and FS.http://www.sciencedirect.com/science/article/pii/S0753332223017894IDAIron supplementationPolysaccharide iron complexIron protein succinylateFerrous succinate |
| spellingShingle | Huanhuan Yang Xiaoling Zang Xinyu Jin Jiejun Chen Yinggang Lv Zhihua Lv Efficacy of polysaccharide iron complex in IDA rats: A comparative study with iron protein succinylate and ferrous succinate Biomedicine & Pharmacotherapy IDA Iron supplementation Polysaccharide iron complex Iron protein succinylate Ferrous succinate |
| title | Efficacy of polysaccharide iron complex in IDA rats: A comparative study with iron protein succinylate and ferrous succinate |
| title_full | Efficacy of polysaccharide iron complex in IDA rats: A comparative study with iron protein succinylate and ferrous succinate |
| title_fullStr | Efficacy of polysaccharide iron complex in IDA rats: A comparative study with iron protein succinylate and ferrous succinate |
| title_full_unstemmed | Efficacy of polysaccharide iron complex in IDA rats: A comparative study with iron protein succinylate and ferrous succinate |
| title_short | Efficacy of polysaccharide iron complex in IDA rats: A comparative study with iron protein succinylate and ferrous succinate |
| title_sort | efficacy of polysaccharide iron complex in ida rats a comparative study with iron protein succinylate and ferrous succinate |
| topic | IDA Iron supplementation Polysaccharide iron complex Iron protein succinylate Ferrous succinate |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223017894 |
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