Assessment of the anesthetic effect of modified pentothal sodium solution on Sprague-Dawley rats
Clinically, pentothal sodium has been widely used for primary and general anesthesia induction. Also, it has been used to effectively inhibit convulsion. Pentothal sodium has a strong inhibitory effect on the respiratory center, excessive drug administration, and rapid dose rate that cause death of...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2022-05-01
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| Series: | Open Life Sciences |
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| Online Access: | https://doi.org/10.1515/biol-2022-0050 |
| _version_ | 1797998127390654464 |
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| author | Chen Xianzhen Wang Shiqing Li Youjiong Lin Chunjin Liu Xiaofang |
| author_facet | Chen Xianzhen Wang Shiqing Li Youjiong Lin Chunjin Liu Xiaofang |
| author_sort | Chen Xianzhen |
| collection | DOAJ |
| description | Clinically, pentothal sodium has been widely used for primary and general anesthesia induction. Also, it has been used to effectively inhibit convulsion. Pentothal sodium has a strong inhibitory effect on the respiratory center, excessive drug administration, and rapid dose rate that cause death of experimental animals on the respiratory depression. This study used a modified pentothal sodium solution to investigate its anesthetic effect. The pentothal sodium solution was modified based on pentothal sodium upon additions of magnesium sulfate, propylene glycol, and pure ethanol. The anesthetic effect of the modified pentothal sodium on Sprague–Dawley (SD) rats was investigated by comparing traditional pentothal sodium and ketamine; 60 SD rats were randomly divided into three groups. Each group was treated with traditional pentothal sodium, modified pentothal sodium, or ketamine, respectively, via intraperitoneal injection. The symptoms of experimental rats were observed, and onset time and anesthetic time were both recorded. The data were analyzed using statistical software. There were no significant differences in onset time and anesthetic time between the three groups. The variation of onset time and anesthetic time of the group treated with modified pentothal sodium was shorter than that of the other two groups. Furthermore, the number of anesthetic rats after the first injection was significantly higher than that of the other two groups. The modified pentothal sodium is capable of providing a stable anesthetic effect. The function and effect are much better than traditional pentothal sodium and ketamine. |
| first_indexed | 2024-04-11T10:43:39Z |
| format | Article |
| id | doaj.art-ad4552e013c04ab182c7e0ff29688b33 |
| institution | Directory Open Access Journal |
| issn | 2391-5412 |
| language | English |
| last_indexed | 2024-04-11T10:43:39Z |
| publishDate | 2022-05-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Life Sciences |
| spelling | doaj.art-ad4552e013c04ab182c7e0ff29688b332022-12-22T04:29:08ZengDe GruyterOpen Life Sciences2391-54122022-05-0117148348710.1515/biol-2022-0050Assessment of the anesthetic effect of modified pentothal sodium solution on Sprague-Dawley ratsChen Xianzhen0Wang Shiqing1Li Youjiong2Lin Chunjin3Liu Xiaofang4Department of Anesthesia, Women and Children’s Hospital Affiliated to Xiamen University, 10 Zhenhai Road, Siming, Xiamen, 361001, People’s Republic of ChinaDepartment of Anesthesia, Women and Children’s Hospital Affiliated to Xiamen University, 10 Zhenhai Road, Siming, Xiamen, 361001, People’s Republic of ChinaDepartment of Anesthesia, Women and Children’s Hospital Affiliated to Xiamen University, 10 Zhenhai Road, Siming, Xiamen, 361001, People’s Republic of ChinaDepartment of Anesthesia, Women and Children’s Hospital Affiliated to Xiamen University, 10 Zhenhai Road, Siming, Xiamen, 361001, People’s Republic of ChinaDepartment of Anesthesia, Women and Children’s Hospital Affiliated to Xiamen University, 10 Zhenhai Road, Siming, Xiamen, 361001, People’s Republic of ChinaClinically, pentothal sodium has been widely used for primary and general anesthesia induction. Also, it has been used to effectively inhibit convulsion. Pentothal sodium has a strong inhibitory effect on the respiratory center, excessive drug administration, and rapid dose rate that cause death of experimental animals on the respiratory depression. This study used a modified pentothal sodium solution to investigate its anesthetic effect. The pentothal sodium solution was modified based on pentothal sodium upon additions of magnesium sulfate, propylene glycol, and pure ethanol. The anesthetic effect of the modified pentothal sodium on Sprague–Dawley (SD) rats was investigated by comparing traditional pentothal sodium and ketamine; 60 SD rats were randomly divided into three groups. Each group was treated with traditional pentothal sodium, modified pentothal sodium, or ketamine, respectively, via intraperitoneal injection. The symptoms of experimental rats were observed, and onset time and anesthetic time were both recorded. The data were analyzed using statistical software. There were no significant differences in onset time and anesthetic time between the three groups. The variation of onset time and anesthetic time of the group treated with modified pentothal sodium was shorter than that of the other two groups. Furthermore, the number of anesthetic rats after the first injection was significantly higher than that of the other two groups. The modified pentothal sodium is capable of providing a stable anesthetic effect. The function and effect are much better than traditional pentothal sodium and ketamine.https://doi.org/10.1515/biol-2022-0050pentothal sodiumketamineanesthetic effectintraperitoneal injection |
| spellingShingle | Chen Xianzhen Wang Shiqing Li Youjiong Lin Chunjin Liu Xiaofang Assessment of the anesthetic effect of modified pentothal sodium solution on Sprague-Dawley rats Open Life Sciences pentothal sodium ketamine anesthetic effect intraperitoneal injection |
| title | Assessment of the anesthetic effect of modified pentothal sodium solution on Sprague-Dawley rats |
| title_full | Assessment of the anesthetic effect of modified pentothal sodium solution on Sprague-Dawley rats |
| title_fullStr | Assessment of the anesthetic effect of modified pentothal sodium solution on Sprague-Dawley rats |
| title_full_unstemmed | Assessment of the anesthetic effect of modified pentothal sodium solution on Sprague-Dawley rats |
| title_short | Assessment of the anesthetic effect of modified pentothal sodium solution on Sprague-Dawley rats |
| title_sort | assessment of the anesthetic effect of modified pentothal sodium solution on sprague dawley rats |
| topic | pentothal sodium ketamine anesthetic effect intraperitoneal injection |
| url | https://doi.org/10.1515/biol-2022-0050 |
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