In vivo mapping of hemodynamic responses mediated by tubuloglomerular feedback in hypertensive kidneys
Abstract The kidney has a sophisticated vascular structure that performs the unique function of filtering blood and managing blood pressure. Tubuloglomerular feedback is an intra-nephron negative feedback mechanism stabilizing single-nephron blood flow, glomerular filtration rate, and tubular flow r...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-12-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-49327-3 |
| _version_ | 1797388286256218112 |
|---|---|
| author | Blaire Lee Dmitry D. Postnov Charlotte M. Sørensen Olga Sosnovtseva |
| author_facet | Blaire Lee Dmitry D. Postnov Charlotte M. Sørensen Olga Sosnovtseva |
| author_sort | Blaire Lee |
| collection | DOAJ |
| description | Abstract The kidney has a sophisticated vascular structure that performs the unique function of filtering blood and managing blood pressure. Tubuloglomerular feedback is an intra-nephron negative feedback mechanism stabilizing single-nephron blood flow, glomerular filtration rate, and tubular flow rate, which is exhibited as self-sustained oscillations in single-nephron blood flow. We report the application of multi-scale laser speckle imaging to monitor global blood flow changes across the kidney surface (low zoom) and local changes in individual microvessels (high zoom) in normotensive and spontaneously hypertensive rats in vivo. We reveal significant differences in the parameters of TGF-mediated hemodynamics and patterns of synchronization. Furthermore, systemic infusion of a glucagon-like-peptide-1 receptor agonist, a potential renoprotective agent, induces vasodilation in both groups but only alters the magnitude of the TGF in Sprague Dawleys, although the underlying mechanisms remain unclear. |
| first_indexed | 2024-03-08T22:38:39Z |
| format | Article |
| id | doaj.art-ad46eabeee4e4c0eae8d31cd8a6a0c7d |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-08T22:38:39Z |
| publishDate | 2023-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-ad46eabeee4e4c0eae8d31cd8a6a0c7d2023-12-17T12:18:20ZengNature PortfolioScientific Reports2045-23222023-12-0113111210.1038/s41598-023-49327-3In vivo mapping of hemodynamic responses mediated by tubuloglomerular feedback in hypertensive kidneysBlaire Lee0Dmitry D. Postnov1Charlotte M. Sørensen2Olga Sosnovtseva3Department of Biomedicine, The University of CopenhagenCFIN Department of Clinical Medicine, Aarhus UniversityDepartment of Biomedicine, The University of CopenhagenDepartment of Biomedicine, The University of CopenhagenAbstract The kidney has a sophisticated vascular structure that performs the unique function of filtering blood and managing blood pressure. Tubuloglomerular feedback is an intra-nephron negative feedback mechanism stabilizing single-nephron blood flow, glomerular filtration rate, and tubular flow rate, which is exhibited as self-sustained oscillations in single-nephron blood flow. We report the application of multi-scale laser speckle imaging to monitor global blood flow changes across the kidney surface (low zoom) and local changes in individual microvessels (high zoom) in normotensive and spontaneously hypertensive rats in vivo. We reveal significant differences in the parameters of TGF-mediated hemodynamics and patterns of synchronization. Furthermore, systemic infusion of a glucagon-like-peptide-1 receptor agonist, a potential renoprotective agent, induces vasodilation in both groups but only alters the magnitude of the TGF in Sprague Dawleys, although the underlying mechanisms remain unclear.https://doi.org/10.1038/s41598-023-49327-3 |
| spellingShingle | Blaire Lee Dmitry D. Postnov Charlotte M. Sørensen Olga Sosnovtseva In vivo mapping of hemodynamic responses mediated by tubuloglomerular feedback in hypertensive kidneys Scientific Reports |
| title | In vivo mapping of hemodynamic responses mediated by tubuloglomerular feedback in hypertensive kidneys |
| title_full | In vivo mapping of hemodynamic responses mediated by tubuloglomerular feedback in hypertensive kidneys |
| title_fullStr | In vivo mapping of hemodynamic responses mediated by tubuloglomerular feedback in hypertensive kidneys |
| title_full_unstemmed | In vivo mapping of hemodynamic responses mediated by tubuloglomerular feedback in hypertensive kidneys |
| title_short | In vivo mapping of hemodynamic responses mediated by tubuloglomerular feedback in hypertensive kidneys |
| title_sort | in vivo mapping of hemodynamic responses mediated by tubuloglomerular feedback in hypertensive kidneys |
| url | https://doi.org/10.1038/s41598-023-49327-3 |
| work_keys_str_mv | AT blairelee invivomappingofhemodynamicresponsesmediatedbytubuloglomerularfeedbackinhypertensivekidneys AT dmitrydpostnov invivomappingofhemodynamicresponsesmediatedbytubuloglomerularfeedbackinhypertensivekidneys AT charlottemsørensen invivomappingofhemodynamicresponsesmediatedbytubuloglomerularfeedbackinhypertensivekidneys AT olgasosnovtseva invivomappingofhemodynamicresponsesmediatedbytubuloglomerularfeedbackinhypertensivekidneys |