The Effect of KATP Channel Blocker Glibenclamide on CGRP-Induced Headache and Hemodynamic in Healthy Volunteers

The Effect of KATP Channel Blocker Glibenclamide on CGRP-Induced Headache and Hemodynamic in Healthy Volunteers

BackgroundCalcitonin gene-related peptide (CGRP) dilates cranial arteries and triggers headache. The CGRP signaling pathway is partly dependent on activation of ATP-sensitive potassium (KATP) channels. Here, we investigated the effect of the KATP channel blocker glibenclamide on CGRP-induced headach...

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Bibliographic Details
Main Authors: Hande Coskun, Fatima Azzahra Elbahi, Mohammad Al-Mahdi Al-Karagholi, Hashmat Ghanizada, Majid Sheykhzade, Messoud Ashina
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Physiology
Subjects:
humans
migraine
glyburide
calcitonin-gene related peptide
cranial arteries
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.652136/full

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