Natural Bio-Inks for 3D Bioprinting of Cancer Tumor Models
The engineering of convenient three-dimensional (3D) <i>in vitro</i> tumor models presents many challenges, but they are increasingly identifying as one of the best preclinical drug-screening platforms and a developed method to research cancer in controlled conditions in the lab. Recentl...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-01-01
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| Series: | Proceedings |
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| Online Access: | https://www.mdpi.com/2504-3900/40/1/44 |
| _version_ | 1811333464839946240 |
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| author | Tuğrul Tolga Demirtaş |
| author_facet | Tuğrul Tolga Demirtaş |
| author_sort | Tuğrul Tolga Demirtaş |
| collection | DOAJ |
| description | The engineering of convenient three-dimensional (3D) <i>in vitro</i> tumor models presents many challenges, but they are increasingly identifying as one of the best preclinical drug-screening platforms and a developed method to research cancer in controlled conditions in the lab. Recently advanced 3D bioprinting techniques can be enhanced to produce biomimetic and complex tumor structures. The native tumors have complex structures originating from different extracellular matrix materials, cell types, and biomolecules. To obtain this, multifactorial bio-inks to consist of multiple hydrogel biomaterials (alginate, collagen, fibrin, gelatin, and chitosan as natural bio-inks), patient-derived different types of cancer cells, and soluble factors have been advanced. 3D bioprinting of live human cells has shown that effective in vitro replication of tumor biology is achievable. Several last research outline current improvements in the use of bio-printed tumor models used in cancer research, enhancing a new boundary for the understanding of tumor biology and the progress of cancer therapies. |
| first_indexed | 2024-04-13T16:53:15Z |
| format | Article |
| id | doaj.art-ad488f2024dc4dd1870f86113b410bca |
| institution | Directory Open Access Journal |
| issn | 2504-3900 |
| language | English |
| last_indexed | 2024-04-13T16:53:15Z |
| publishDate | 2020-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Proceedings |
| spelling | doaj.art-ad488f2024dc4dd1870f86113b410bca2022-12-22T02:38:53ZengMDPI AGProceedings2504-39002020-01-014014410.3390/proceedings2019040044proceedings2019040044Natural Bio-Inks for 3D Bioprinting of Cancer Tumor ModelsTuğrul Tolga Demirtaş0Department of Basic Pharmaceutical Sciences, Faculty of Pharmacy, Erciyes University, 38039 Kayseri, TurkeyThe engineering of convenient three-dimensional (3D) <i>in vitro</i> tumor models presents many challenges, but they are increasingly identifying as one of the best preclinical drug-screening platforms and a developed method to research cancer in controlled conditions in the lab. Recently advanced 3D bioprinting techniques can be enhanced to produce biomimetic and complex tumor structures. The native tumors have complex structures originating from different extracellular matrix materials, cell types, and biomolecules. To obtain this, multifactorial bio-inks to consist of multiple hydrogel biomaterials (alginate, collagen, fibrin, gelatin, and chitosan as natural bio-inks), patient-derived different types of cancer cells, and soluble factors have been advanced. 3D bioprinting of live human cells has shown that effective in vitro replication of tumor biology is achievable. Several last research outline current improvements in the use of bio-printed tumor models used in cancer research, enhancing a new boundary for the understanding of tumor biology and the progress of cancer therapies.https://www.mdpi.com/2504-3900/40/1/44natural bio-inks3d bioprintingcancer tumor models |
| spellingShingle | Tuğrul Tolga Demirtaş Natural Bio-Inks for 3D Bioprinting of Cancer Tumor Models Proceedings natural bio-inks 3d bioprinting cancer tumor models |
| title | Natural Bio-Inks for 3D Bioprinting of Cancer Tumor Models |
| title_full | Natural Bio-Inks for 3D Bioprinting of Cancer Tumor Models |
| title_fullStr | Natural Bio-Inks for 3D Bioprinting of Cancer Tumor Models |
| title_full_unstemmed | Natural Bio-Inks for 3D Bioprinting of Cancer Tumor Models |
| title_short | Natural Bio-Inks for 3D Bioprinting of Cancer Tumor Models |
| title_sort | natural bio inks for 3d bioprinting of cancer tumor models |
| topic | natural bio-inks 3d bioprinting cancer tumor models |
| url | https://www.mdpi.com/2504-3900/40/1/44 |
| work_keys_str_mv | AT tugrultolgademirtas naturalbioinksfor3dbioprintingofcancertumormodels |